Standardized Extract from Wastes of Edible Flowers and Snail Mucus Ameliorate Ultraviolet B-Induced Damage in Keratinocytes

Article Dermatology

Protective effect of γ-glutamylcysteine against UVB radiation in NIH-3T3 cells

Shuai Lu et al.

Summary: gamma-GC can reduce UVB-induced damage to NIH-3T3 cells by strengthening the endogenous antioxidant defense system, preventing DNA damage, and inhibiting the activation of the MAPK pathway.

PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE (2022)

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Article Biochemistry & Molecular Biology

Heme Oxygenase Modulation Drives Ferroptosis in TNBC Cells

Valeria Consoli et al.

Summary: Ferroptosis is suggested as a potential new strategy for treating breast cancer, particularly triple negative breast cancer. The study reveals the importance of HO in ferroptosis, with HO-1 induction potentially accelerating the process.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Cell Biology

Phytocomplex of a Standardized Extract from Red Orange (Citrus sinensis L. Osbeck) against Photoaging

Barbara Tomasello et al.

Summary: This study investigated the photoprotective activity of a phytocomplex derived from red oranges on human skin cells. The extract showed strong antioxidant properties, protecting cells from oxidative stress and DNA damage caused by UVA-B exposure. It also downregulated proinflammatory markers and MMPs, promoting the remodeling of the extracellular matrix through collagen and elastin expression. The red orange extract represents a safe and effective option for preventing photoaging.

CELLS (2022)

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Review Biochemistry & Molecular Biology

Nutraceutical potential of dietary phytochemicals in edible flowers-A review

Ganesamoorthy Janarny et al.

Summary: Edible flowers, with their rich phytochemical content, have various health benefits such as antioxidant, anti-inflammatory, and anticancer properties. However, many varieties of edible flowers remain underexplored and underutilized. Further research and incorporation into commercialized products are needed to deliver the potential health benefits to consumers.

JOURNAL OF FOOD BIOCHEMISTRY (2021)

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Article Biochemistry & Molecular Biology

Protective Effect of Anthocyanin-Enriched Polyphenols from Hibiscus syriacus L. (Malvaceae) against Ultraviolet B-Induced Damage

Wisurumuni Arachchilage Hasitha Maduranga Karunarathne et al.

Summary: The study found that AHs extracted from the flower petals of H. syriacus L. have anti-aging, antioxidant, and anti-melanogenic properties, protecting the skin from UVB-induced photodamage. AHs prevented apoptosis, ER stress, and mtROS production induced by UVB irradiation, effectively preventing skin cell damage.

ANTIOXIDANTS (2021)

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Article Biochemistry & Molecular Biology

Tin Mesoporphyrin Selectively Reduces Non-Small-Cell Lung Cancer Cell Line A549 Proliferation by Interfering with Heme Oxygenase and Glutathione Systems

Valeria Sorrenti et al.

Summary: The overexpression of HO-1 in NSCLC cells and the inhibitory effect of SnMP on cell proliferation and migration, as well as the increase in oxidative stress, suggest that HO activity inhibition may be a potential target for selective chemotherapy in lung cancer subtypes.

BIOMOLECULES (2021)

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Article Biochemistry & Molecular Biology

Novel mutual prodrug of 5-fluorouracil and heme oxygenase-1 inhibitor (5-FU/HO-1 hybrid): design and preliminary in vitro evaluation

Loredana Salerno et al.

Summary: The first mutual prodrug of 5-fluorouracil and heme oxygenase1 inhibitor (5-FU/HO-1 hybrid) was designed, synthesised, and evaluated for its stability and cytotoxicity against cancer cell lines. The newly synthesised hybrid demonstrated drug-like properties with low toxic liabilities and potential as a novel anticancer agent, particularly effective against lung cancer cells while showing lower cytotoxicity towards healthy lung epithelial cells.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2021)

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Review Biochemistry & Molecular Biology