☆ 4.7 Review

The Role of Bitter Melon in Breast and Gynecological Cancer Prevention and Therapy

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

Related references

Note: Only part of the references are listed.

Review Oncology

The Emerging Role of Histone Deacetylase Inhibitors in Cervical Cancer Therapy

Iason Psilopatis et al.

Summary: Histone deacetylase inhibitors (HDACIs) have important effects on epigenetic regulation in cancer, including inducing cancer cell death, apoptosis, and cell cycle arrest. Although mainly approved for hematologic malignancies, there are promising studies in cervical cancer. This comprehensive review examines the role of HDACIs in the treatment of cervical cancer and discusses their potential as effective anticancer drugs, either alone or in combination with other treatments.

CANCERS (2023)

Add to Collection

Article Cell Biology

Anticancer Activity of Bitter Melon-Derived Vesicles Extract against Breast Cancer

Ting Feng et al.

Summary: Due to its low immunogenicity, high biocompatibility, and ready availability in large quantities, plant-derived vesicles extracts have gained considerable attention as a novel nanomaterial in tumor therapy. This study found that bitter melon-derived vesicles extract (BMVE) exhibits significant inhibitory effects on breast cancer, including anti-proliferative, migration-inhibiting, and apoptosis-inducing effects. Furthermore, BMVE can effectively inhibit tumor growth in vivo with negligible adverse effects. These findings highlight the potential of BMVE as a promising therapeutic agent for breast cancer treatment.

CELLS (2023)

Add to Collection

Article Public, Environmental & Occupational Health

Trends in Incidence and Mortality of Gynecological and Breast Cancers in Poland (1980-2018)

Marcin Piechocki et al.

Summary: This study analyzed the incidence and mortality trends of gynecological and breast cancers in Poland from 1980 to 2018. The results showed an increase in the incidence of certain cancers and a decrease in others. Breast cancer mortality showed initial fluctuation and then began to increase.

CLINICAL EPIDEMIOLOGY (2022)

Add to Collection

Article Gastroenterology & Hepatology

Perspectives of East Asian patients and physicians on complementary and alternative medicine use for inflammatory bowel disease: results of a cross-sectional, multinational study

Eun Soo Kim et al.

Summary: This study investigated the prevalence and pattern of CAM use among East Asian IBD patients and identified factors associated with CAM use. The results showed that 8.6% of patients used CAM services for their disease, while 29.7% of patients sought at least one kind of CAM product. Current active disease and Chinese or South Korean nationality were independent predictors of CAM use.

INTESTINAL RESEARCH (2022)

Add to Collection

Article Oncology

Ribosome-inactivating protein MAP30 isolated from Momordica charantia L. induces apoptosis in hepatocellular carcinoma cells

Wei Zhao et al.

Recent Patents on Anti-Cancer Drug Discovery (2022)

Add to Collection

Review Medicine, Research & Experimental

Phytotherapeutic applications of alkaloids in treating breast cancer

Shailima Rampogu et al.

Summary: Breast cancer is a major cause of female mortality worldwide. Current treatments have side effects, leading to the exploration of natural compounds. Alkaloids, a group of natural compounds, have gained attention for their potential therapeutic use in breast cancer due to their anti-inflammatory, antiviral, and antimicrobial properties. This review discusses 12 alkaloids that have shown promise in inducing apoptosis, inhibiting tumor growth and migration, and inducing autophagy, making them potential components of combination therapy for breast cancer.

BIOMEDICINE & PHARMACOTHERAPY (2022)

Add to Collection

Article Health Care Sciences & Services

Clinical Significance of the Histone Deacetylase 2 (HDAC-2) Expression in Human Breast Cancer

Nikolaos Garmpis et al.

Summary: This study found a relationship between HDAC-2 expression and clinical features and survival of breast cancer. Higher expression of HDAC-2 was correlated with the aggressiveness and poor prognosis of breast cancer.

JOURNAL OF PERSONALIZED MEDICINE (2022)

Add to Collection

Review Food Science & Technology

A comprehensive review on bitter gourd (Momordica charantia L.) as a gold mine of functional bioactive components for therapeutic foods

K. S. Gayathry et al.

Summary: Bitter gourd, a tropical vegetable grown mainly in Asia, is being studied for its rich nutrients and potential health benefits. Despite its bitter taste, it contains over 60 phytochemical compounds that have been found to have medicinal properties, including anti-cancer and anti-diabetic effects. Researchers are exploring ways to incorporate these bioactive compounds into functional foods and beverages.

FOOD PRODUCTION PROCESSING AND NUTRITION (2022)

Add to Collection

Review Biotechnology & Applied Microbiology

Histone Deacetylase Inhibitors: A Promising Therapeutic Alternative for Endometrial Carcinoma

Iason Psilopatis et al.

Summary: Histone deacetylase inhibitors have shown promising therapeutic potential in endometrial cancer by inhibiting tumor growth, inducing cell cycle arrest and apoptosis. Histone acetylation plays a critical role in the development and progression of endometrial carcinoma. Additional clinical trials are needed to further evaluate the clinical utility and safety of these agents in treating patients with endometrial cancer.

DISEASE MARKERS (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Oxysterols and lipidomic profile of myocardium of rats supplemented with pomegranate seed oil and/or bitter melon aqueous extract - Cardio-ontological animal model research

Agnieszka Bialek et al.

Summary: The study found that dietary supplements did not have a significant impact on cardiovascular diseases and cancer, but they were able to reduce cholesterol levels. The cancer process reduced the incorporation of conjugated fatty acids in cardiac tissue, while the antioxidant properties of pomegranate seed oil and bitter melon extract had minimal effects in pathological conditions.

CHEMISTRY AND PHYSICS OF LIPIDS (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Anticancer Properties of Eugenol: A Review

Ali T. Zari et al.

Summary: Eugenol, the principal active component of clove, exhibits anticancer, antioxidant, anti-inflammatory, and antimicrobial properties. It shows promising effects in inducing cell death, cell cycle arrest, and inhibiting migration, metastasis, and angiogenesis in various cancer cell lines. Additionally, when used as an adjunct therapy to conventional chemotherapy, eugenol enhances effectiveness while reducing toxicity, making it a valuable candidate for cancer treatment.

MOLECULES (2021)

Add to Collection

Article Plant Sciences

Momordica charantia L. induces non-apoptotic cell death in human MDA-MB-436 breast and A549 lung cancer cells by disrupting energy metabolism and exacerbating reactive oxygen species' generation

Adeola Folasade Ehigie et al.

Summary: The study aimed to investigate the mechanism of cell death in breast and lung cancer cell lines treated with fractions derived from bitter melon extract. The results showed that the fractions reduced mitochondrial membrane potential and intracellular ATP levels, while increasing reactive oxygen species levels. However, they did not activate caspase-3 or release cytochrome c in the cancer cells, suggesting a different mechanism of cell death induction.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

Add to Collection

Article Oncology

Comparative Pre-clinical Efficacy of Chinese and Indian Cultivars of Bitter Melon (Momordica charantia) against Pancreatic Cancer

Kushal Kandhari et al.

Summary: Comparative pre-clinical studies showed that Chinese and Indian bitter melon varieties exhibit comparable efficacy in inhibiting pancreatic cancer cell proliferation, inducing cell death, suppressing tumor growth, and decreasing angiogenesis. The geographical availability of a particular cultivar should not be a limiting factor in selecting a variant for clinical trials.

JOURNAL OF CANCER PREVENTION (2021)

Add to Collection

Article Oncology

Momordicine-I, a Bitter Melon Bioactive Metabolite, Displays Anti-Tumor Activity in Head and Neck Cancer Involving c-Met and Downstream Signaling

Subhayan Sur et al.

Summary: Head and neck cancer (HNC) is a highly aggressive cancer with limited treatment options. Momordicine-I (M-I), found in bitter melon extract, has shown significant potential in inhibiting HNC cell growth and tumor progression. M-I works by targeting c-Met and downstream signaling molecules, offering a promising alternative therapeutic approach for managing HNC.

CANCERS (2021)

Add to Collection

Article Integrative & Complementary Medicine

Efficacy and Safety of Chinese Herbal Medicine on Treatment of Breast Cancer: A Meta-analysis of Randomized Controlled Trials

Venice Wing-Tung Ho et al.

Summary: The study evaluating the clinical effectiveness of Chinese herbal medicine (CHM) on breast cancer found that combined therapy with CHM and Western medicine could improve tumor response and survival rates. Further studies with stratification of tumor stages and intervention types are highly warranted to explore the potential benefits of complementary CHM therapy for breast cancer patients.

AMERICAN JOURNAL OF CHINESE MEDICINE (2021)

Add to Collection

Article Oncology

The Effect of Bitter Melon (Momordica charantia) Extract on the Uptake of 99mTc Labeled Paclitaxel: In Vitro Monitoring in Breast Cancer Cells

Ayfer Y. Kilcar et al.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2020)

Add to Collection

Review Oncology

Bitter Melon (Momordica Charantia), a Nutraceutical Approach for Cancer Prevention and Therapy

Subhayan Sur et al.

CANCERS (2020)

Add to Collection

Review Biochemistry & Molecular Biology

Potential Treatment of Breast and Lung Cancer Using Dicoma anomala, an African Medicinal Plant

Alexander Chota et al.

MOLECULES (2020)

Add to Collection

Article Pharmacology & Pharmacy

MAP30 protein from Momordica charantia is therapeutic and has synergic activity with cisplatin against ovarian cancer in vivo by altering metabolism and inducing ferroptosis

David W. Chan et al.

PHARMACOLOGICAL RESEARCH (2020)

Add to Collection

Article Biochemistry & Molecular Biology

MAP30 Inhibits Bladder Cancer Cell Migration and Invasion In Vitro Through Suppressing Akt Pathway and the Epithelial/Mesenchymal Transition Process

Shaoqi Zhang et al.

DNA AND CELL BIOLOGY (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Mammary cancer risk and serum lipid profile of rats supplemented with pomegranate seed oil and bitter melon extract

Tomasz Lepionka et al.

PROSTAGLANDINS & OTHER LIPID MEDIATORS (2019)

Add to Collection

Article Cell Biology

Bitter taste receptors are expressed in human epithelial ovarian and prostate cancers cells and noscapine stimulation impacts cell survival

Louis T. P. Martin et al.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2019)

Add to Collection

Review Medicine, Research & Experimental

Corilagin, a promising medicinal herbal agent

Xuan Li et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

Add to Collection

Article Biochemistry & Molecular Biology

Disrupting cholesterol esterification by bitter melon suppresses triple-negative breast cancer cell growth

So Hee Shim et al.

MOLECULAR CARCINOGENESIS (2018)

Add to Collection

Article Chemistry, Medicinal

Kuguacin J isolated from bitter melon leaves modulates paclitaxel sensitivity in drug-resistant human ovarian cancer cells

Pornsiri Pitchakarn et al.

JOURNAL OF NATURAL MEDICINES (2017)

Add to Collection

Article Chemistry, Medicinal

Identification of a Triterpenoid as a Novel PPAR Activator Derived from Formosan Plants

Jing-Ru Weng et al.

PHYTOTHERAPY RESEARCH (2017)

Add to Collection

Article Oncology

Bitter melon extract inhibits breast cancer growth in preclinical model by inducing autophagic cell death

Naoshad Muhammad et al.

ONCOTARGET (2017)

Add to Collection

Review Oncology

Histone Deacetylase Inhibitors: An Attractive Therapeutic Strategy Against Breast Cancer

Christos Damaskos et al.

ANTICANCER RESEARCH (2017)

Add to Collection

Article Health Care Sciences & Services

Use of traditional medicine in middle-income countries: a WHO-SAGE study

Oyinlola Oyebode et al.

HEALTH POLICY AND PLANNING (2016)

Add to Collection

Article Oncology

Bitter Melon (Momordica charantia) Extract Inhibits Tumorigenicity and Overcomes Cisplatin-Resistance in Ovarian Cancer Cells Through Targeting AMPK Signaling Cascade

Mingo M. H. Yung et al.

INTEGRATIVE CANCER THERAPIES (2016)

Add to Collection

Review Oncology

Promise of bitter melon (Momordica charantia) bioactives in cancer prevention and therapy

Kornai Raina et al.

SEMINARS IN CANCER BIOLOGY (2016)

Add to Collection

Article Pharmacology & Pharmacy

PEGylation alleviates the non-specific toxicities of Alpha-Momorcharin and preserves its antitumor efficacy in vivo

Nian-hua Deng et al.

DRUG DELIVERY (2016)

Add to Collection

Article Multidisciplinary Sciences

A triterpenoid from wild bitter gourd inhibits breast cancer cells

Li-Yuan Bai et al.

SCIENTIFIC REPORTS (2016)

Add to Collection

Article Chemistry, Medicinal

Alpha-momorcharin (α-MMC) exerts effective anti-human breast tumor activities but has a narrow therapeutic window in vivo

Dongliang Cao et al.

FITOTERAPIA (2015)

Add to Collection

Article Integrative & Complementary Medicine

Cucurbitane Triterpenoid from Momordica charantia Induces Apoptosis and Autophagy in Breast Cancer Cells, in Part, through Peroxisome Proliferator-Activated Receptor gamma Activation

Jing-Ru Weng et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2013)

Add to Collection

Review Pharmacology & Pharmacy

Plants and cervical cancer: an overview

Su-Juan Wang et al.

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2013)

Add to Collection

Article Biochemistry & Molecular Biology

RNase MC2: a new Momordica charantia ribonuclease that induces apoptosis in breast cancer cells associated with activation of MAPKs and induction of caspase pathways

Evandro Fei Fang et al.

APOPTOSIS (2012)

Add to Collection

Article Biochemistry & Molecular Biology

Kuguacin J isolated from Momordica charantia leaves inhibits P-glycoprotein (ABCB1)-mediated multidrug resistance

Pornsiri Pitchakarn et al.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2012)

Add to Collection

Article Oncology

Eleostearic Acid Inhibits Breast Cancer Proliferation by Means of an Oxidation-Dependent Mechanism

Michael E. Grossmann et al.

CANCER PREVENTION RESEARCH (2009)

Add to Collection

Article Oncology

Inhibition of P-glycoprotein activity and reversal of cancer multidrug resistance by Momordica charantia extract

P Limtrakul et al.

CANCER CHEMOTHERAPY AND PHARMACOLOGY (2004)

Add to Collection

Article Integrative & Complementary Medicine

Effects of bitter melon (Momordica charantia L.) or Ginger Rhizome (Zingiber offifinale Rosc) on spontaneous mammary tumorigenesis in SHN mice

H Nagasawa et al.

AMERICAN JOURNAL OF CHINESE MEDICINE (2002)

Add to Collection

© Peeref 2019-2024. All rights reserved.