☆ 4.7 Review

Unraveling the Complex Interplay between Alpha-Synuclein and Epigenetic Modification

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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JOURNAL OF NEUROSCIENCE RESEARCH (2019)

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Article Biochemistry & Molecular Biology

Sumoylated -synuclein translocates into the nucleus by karyopherin 6

Seungjin Ryu et al.

MOLECULAR & CELLULAR TOXICOLOGY (2019)

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Article Clinical Neurology

Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies

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LANCET NEUROLOGY (2019)

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Article Neurosciences

Distinct Stress Response and Altered Striatal Transcriptome in Alpha-Synuclein Overexpressing Mice

Zinah Wassouf et al.

FRONTIERS IN NEUROSCIENCE (2019)

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Article Neurosciences

Modeling Parkinson's disease in midbrain-like organoids

Lisa M. Smits et al.

NPJ PARKINSONS DISEASE (2019)

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Review Genetics & Heredity

The DNA methyltransferase family: a versatile toolkit for epigenetic regulation

Frank Lyko

NATURE REVIEWS GENETICS (2018)

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Article Biochemistry & Molecular Biology

Nuclear Import Receptor Inhibits Phase Separation of FUS through Binding to Multiple Sites

Takuya Yoshizawa et al.

CELL (2018)

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Article Neurosciences

Inoculation of α-synuclein preformed fibrils into the mouse gastrointestinal tract induces Lewy body-like aggregates in the brainstem via the vagus nerve

Norihito Uemura et al.

MOLECULAR NEURODEGENERATION (2018)

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Article Neurosciences

Environmental Enrichment Prevents Transcriptional Disturbances Induced by Alpha-Synuclein Overexpression

Zinah Wassouf et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2018)

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Article Neurosciences

Sporadic Parkinson's disease derived neuronal cells show disease-specific mRNA and small RNA signatures with abundant deregulation of piRNAs

Markus Schulze et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2018)

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Article Clinical Neurology

A comprehensive analysis of SNCA-related genetic risk in sporadic parkinson disease

Lasse Pihlstrom et al.

ANNALS OF NEUROLOGY (2018)

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Article Biochemical Research Methods

Millifluidic culture improves human midbrain organoid vitality and differentiation

Emanuel Berger et al.

LAB ON A CHIP (2018)

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Article Biotechnology & Applied Microbiology

Downregulation of SNCA Expression by Targeted Editing of DNA Methylation: A Potential Strategy for Precision Therapy in PD

Boris Kantor et al.

MOLECULAR THERAPY (2018)

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Article Biochemistry & Molecular Biology

Neurodegenerative Disease Proteinopathies Are Connected to Distinct Histone Post-translational Modification Landscapes

Karen Chen et al.

ACS CHEMICAL NEUROSCIENCE (2018)

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Article Clinical Neurology

Histones facilitate α-synuclein aggregation during neuronal apoptosis

Peizhou Jiang et al.

ACTA NEUROPATHOLOGICA (2017)

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Article Neurosciences

Nuclear Accumulation of Histone Deacetylase 4 (HDAC4) Exerts Neurotoxicity in Models of Parkinson's Disease

Qimei Wu et al.

MOLECULAR NEUROBIOLOGY (2017)

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Article Clinical Neurology

DNA methylation changes at SNCA intron 1 in patients with dementia with Lewy bodies

Yu Funahashi et al.

PSYCHIATRY AND CLINICAL NEUROSCIENCES (2017)

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Article Biochemistry & Molecular Biology

Sodium butyrate rescues dopaminergic cells from alpha-synuclein-induced transcriptional deregulation and DNA damage

Isabel Paiva et al.

HUMAN MOLECULAR GENETICS (2017)

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Review Biochemistry & Molecular Biology

Arginine Methylation: The Coming of Age

Romeo S. Blanc et al.

MOLECULAR CELL (2017)

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Review Neurosciences

The SH-SY5Y cell line in Parkinson's disease research: a systematic review

Helena Xicoy et al.

MOLECULAR NEURODEGENERATION (2017)

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Review Genetics & Heredity

TET-mediated active DNA demethylation: mechanism, function and beyond

Xiaoji Wu et al.

NATURE REVIEWS GENETICS (2017)

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Article Neurosciences

Hypomethylation of intron1 of α-synuclein gene does not correlate with Parkinson's disease

Subhrangshu Guhathakurta et al.

MOLECULAR BRAIN (2017)

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Article Neurosciences

Implications of DNA Methylation in Parkinson's Disease

Ernesto Miranda-Morales et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2017)

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Article Cell & Tissue Engineering

Derivation of Human Midbrain-Specific Organoids from Neuroepithelial Stem Cells

Anna S. Monzel et al.

STEM CELL REPORTS (2017)

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Article Biochemistry & Molecular Biology

Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure

Xuyu Qian et al.

CELL (2016)

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Article Cell & Tissue Engineering

Midbrain-like Organoids from Human Pluripotent Stem Cells Contain Functional Dopaminergic and Neuromelanin-Producing Neurons

Junghyun Jo et al.

CELL STEM CELL (2016)

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Article Cell Biology

Simple rules for passive diffusion through the nuclear pore complex

Benjamin L. Timney et al.

JOURNAL OF CELL BIOLOGY (2016)

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Review Biochemistry & Molecular Biology

DNA methylation in Parkinson's disease

Ullrich Wuellner et al.

JOURNAL OF NEUROCHEMISTRY (2016)

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Article Multidisciplinary Sciences

α-Synuclein enhances histone H3 lysine-9 dimethylation and H3K9me2-dependent transcriptional responses

Naoto Sugeno et al.

SCIENTIFIC REPORTS (2016)

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TRIM28 regulates the nuclear accumulation and toxicity of both alpha-synuclein and tau

Maxime W. C. Rousseaux et al.

ELIFE (2016)

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Review Biochemistry & Molecular Biology

The PRMT5 arginine methyltransferase: many roles in development, cancer and beyond

Nicole Stopa et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2015)

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Article Developmental Biology

How to make a midbrain dopaminergic neuron

Ernest Arenas et al.

DEVELOPMENT (2015)

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Article Geriatrics & Gerontology

DNA methylation levels of α-synuclein intron 1 in the aging brain

Laura de Boni et al.

NEUROBIOLOGY OF AGING (2015)

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Article Clinical Neurology

Mutual Exacerbation of Peroxisome Proliferator-Activated Receptor γ Coactivator 1α Deregulation and α-Synuclein Oligomerization

Judith Eschbach et al.

ANNALS OF NEUROLOGY (2015)

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Article Biochemistry & Molecular Biology

Lys-63-linked Ubiquitination by E3 Ubiquitin Ligase Nedd4-1 Facilitates Endosomal Sequestration of Internalized α-Synuclein

Naoto Sugeno et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

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Article Clinical Neurology

Hypomethylation of SNCA in blood of patients with sporadic Parkinson's disease

San-xi Ai et al.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2014)

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Article Clinical Neurology

Methylation of α-synuclein and leucine-rich repeat kinase 2 in leukocyte DNA of Parkinson's disease patients

Yu-yan Tan et al.

PARKINSONISM & RELATED DISORDERS (2014)

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Article Clinical Neurology

Does α-synuclein have a dual and opposing effect in preclinical vs. clinical Parkinson's disease?

Katerina Markopoulou et al.

PARKINSONISM & RELATED DISORDERS (2014)

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Engineering of Midbrain Organoids Containing Long-Lived Dopaminergic Neurons

Vannary Tieng et al.

STEM CELLS AND DEVELOPMENT (2014)

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Distinctive patterns of DNA methylation associated with Parkinson disease Identification of concordant epigenetic changes in brain and peripheral blood leukocytes

Eliezer Masliah et al.

EPIGENETICS (2013)

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Correction: Derivation and Expansion Using Only Small Molecules of Human Neural Progenitors for Neurodegenerative Disease Modeling

Peter Reinhardt et al.

PLoS One (2013)

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Article Biochemistry & Molecular Biology

Selective binding of nuclear alpha-synuclein to the PGC1alpha promoter under conditions of oxidative stress may contribute to losses in mitochondrial function: Implications for Parkinson's disease

Almas Siddiqui et al.

FREE RADICAL BIOLOGY AND MEDICINE (2012)

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Article Biochemistry & Molecular Biology

α-Synuclein Induces Alterations in Adult Neurogenesis in Parkinson Disease Models via p53-mediated Repression of Notch1

Paula Desplats et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

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Accumulation of Toxic α-Synuclein Oligomer within Endoplasmic Reticulum Occurs in α-Synucleinopathy In Vivo

Emanuela Colla et al.

JOURNAL OF NEUROSCIENCE (2012)

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Letter Clinical Neurology

No evidence for differential methylation of α-synuclein in leukocyte DNA of Parkinson's disease patients

Julia Richter et al.

MOVEMENT DISORDERS (2012)

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New insights into nucleosome and chromatin structure: an ordered state or a disordered affair?

Karolin Luger et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)

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New evidence on α-synuclein and Tau binding to conformation and sequence specific GC* rich DNA: Relevance to neurological disorders

P. Vasudevaraju et al.

JOURNAL OF PHARMACY AND BIOALLIED SCIENCES (2012)

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Article Biochemistry & Molecular Biology

α-Synuclein Sequesters Dnmt1 from the Nucleus A NOVEL MECHANISM FOR EPIGENETIC ALTERATIONS IN LEWY BODY DISEASES

Paula Desplats et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

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Article Neurosciences

α-Synuclein Negatively Regulates Protein Kinase Cδ Expression to Suppress Apoptosis in Dopaminergic Neurons by Reducing p300 Histone Acetyltransferase Activity

Huajun Jin et al.

JOURNAL OF NEUROSCIENCE (2011)

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Next-Generation Sequencing Reveals Regional Differences of the α-Synuclein Methylation State Independent of Lewy Body Disease

L. de Boni et al.

NEUROMOLECULAR MEDICINE (2011)

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SNCA Triplication Parkinson's Patient's iPSC-derived DA Neurons Accumulate α-Synuclein and Are Susceptible to Oxidative Stress

Blake Byers et al.

PLOS ONE (2011)

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Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus

Michael J. Devine et al.

NATURE COMMUNICATIONS (2011)

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Article Clinical Neurology

SNARE protein redistribution and synaptic failure in a transgenic mouse model of Parkinson's disease

Pablo Garcia-Reitboeck et al.

BRAIN (2010)

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DNA induced folding/fibrillation of alpha-synuclein: new insights in Parkinson's disease

Muralidhar L. Hegde et al.

FRONTIERS IN BIOSCIENCE-LANDMARK (2010)

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Article Neurosciences

Methylation Regulates Alpha-Synuclein Expression and Is Decreased in Parkinson's Disease Patients' Brains

Ahmad Jowaed et al.

JOURNAL OF NEUROSCIENCE (2010)

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Role of TPPP/p25 on α-synuclein-mediated oligodendroglial degeneration and the protective effect of SIRT2 inhibition in a cellular model of multiple system atrophy

Takafumi Hasegawa et al.

NEUROCHEMISTRY INTERNATIONAL (2010)

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Article Neurosciences

Mitochondrial alpha-synuclein accumulation impairs complex I function in dopaminergic neurons and results in increased mitophagy in vivo

Shankar J. Chinta et al.

NEUROSCIENCE LETTERS (2010)

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Article Multidisciplinary Sciences

CpG Demethylation Enhances Alpha-Synuclein Expression and Affects the Pathogenesis of Parkinson's Disease

Lumine Matsumoto et al.

PLOS ONE (2010)

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α-Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro

Jacqueline Burre et al.

SCIENCE (2010)

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Article Cell Biology

PGC-1α, A Potential Therapeutic Target for Early Intervention in Parkinson's Disease

Bin Zheng et al.

SCIENCE TRANSLATIONAL MEDICINE (2010)

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NUCLEAR AND NEURITIC DISTRIBUTION OF SERINE-129 PHOSPHORYLATED α-SYNUCLEIN IN TRANSGENIC MICE

H. Schell et al.

NEUROSCIENCE (2009)

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Article Multidisciplinary Sciences

An embryonic stem cell chromatin remodeling complex, esBAF, is an essential component of the core pluripotency transcriptional network

Lena Ho et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

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Article Biochemistry & Molecular Biology

Serine 129 phosphorylation of α-synuclein induces unfolded protein response-mediated cell death

Naoto Sugeno et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

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Mitochondrial import and accumulation of α-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain

Latha Devi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

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Article Biochemistry & Molecular Biology

Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally

Yu Zhang et al.

MOLECULAR AND CELLULAR BIOLOGY (2008)

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Review Biochemistry & Molecular Biology

Parkinson's disease

Bobby Thomas et al.

HUMAN MOLECULAR GENETICS (2007)

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Sirtuin 2 inhibitors rescue α-synuclein-mediated toxicity in models of Parkinson's disease

Tiago Fleming Outeiro et al.

SCIENCE (2007)

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Article Biochemistry & Molecular Biology

α-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity

Eirene Kontopoulos et al.

HUMAN MOLECULAR GENETICS (2006)

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Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

Kazutoshi Takahashi et al.

CELL (2006)

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Article Clinical Neurology

Levels of alpha-synuclein mRNA in sporadic Parkinson disease patients

Ornit Chiba-Falek et al.

MOVEMENT DISORDERS (2006)

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Progressive degeneration of human mesencephalic neuron-derived cells triggered by dopamine-dependent oxidative stress is dependent on the mixed-lineage kinase pathway

J Lotharius et al.

JOURNAL OF NEUROSCIENCE (2005)

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Review Cell Biology

Metabolic control through the PGC-1 family of transcription coactivators

JD Lin et al.

CELL METABOLISM (2005)

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Comparison of kindreds with parkinsonism and α-synuclein genomic multiplications

M Farrer et al.

ANNALS OF NEUROLOGY (2004)

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A quantitative investigation of neuronal cytoplasmic and intranuclear inclusions in the pontine and inferior olivary nuclei in multiple system atrophy

M Nishie et al.

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2004)

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Article Multidisciplinary Sciences

α-synuclein locus triplication causes Parkinson's disease

AB Singleton et al.

SCIENCE (2003)

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Nuclear localization of α-synuclein and its interaction with histones

J Goers et al.

BIOCHEMISTRY (2003)

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Neuronal activity-dependent nucleocytoplasmic shuttling of HDAC4 and HDAC5

S Chawla et al.

JOURNAL OF NEUROCHEMISTRY (2003)

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Article Biochemistry & Molecular Biology

Effect of allelic variation at the NACP-Rep1 repeat upstream of the α-synuclein gene (SNCA) on transcription in a cell culture luciferase reporter system

O Chiba-Falek et al.

HUMAN MOLECULAR GENETICS (2001)

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