GSPE Pre-Treatment Exerts Long-Lasting Preventive Effects against Aging-Induced Changes in the Colonic Enterohormone Profile of Female Rats

The impact that healthy aging can have on society has raised great interest in understanding aging mechanisms. However, the effects this biological process may have on the gastrointestinal tract (GIT) have not yet been fully described. Results in relation to changes observed in the enteroendocrine system along the GIT are controversial. Grape seed proanthocyanidin extracts (GSPE) have been shown to protect against several pathologies associated with aging. Based on previous results, we hypothesized that a GSPE pre-treatment could prevent the aging processes that affect the enteroendocrine system. To test this hypothesis, we treated 21-month-old female rats with GSPE for 10 days. Eleven weeks after the treatment, we analyzed the effects of GSPE by comparing these aged animals with young animals. Aging induced a greater endocrine response to stimulation in the upper GIT segments (cholecystokinin (CCK) and glucagon-like peptide-1 (GLP-1)), a decrease in the mRNA abundance of GLP-1, peptide YY (PYY) and chromogranin A (ChgA) in the colon, and an increase in colonic butyrate. GSPE-treated rats were protected against a decrease in enterohormone expression in the colon. This effect is not directly related to the abundance of microbiome or short-chain fatty acids (SCFA) at this location. GSPE may therefore be effective in preventing a decrease in the colonic abundance of enterohormone expression induced by aging.

Automated summary

The impact of healthy aging on society has generated interest in studying aging mechanisms, yet the effects of this process on the gastrointestinal tract are not fully understood. Controversial results have been found regarding changes in the enteroendocrine system along the gastrointestinal tract. Grape seed proanthocyanidin extracts (GSPE) have been shown to protect against aging-related pathologies. In this study, researchers hypothesized that GSPE pre-treatment could prevent aging processes affecting the enteroendocrine system. By treating aged rats with GSPE, they found that the expression of enterohormones in the colon was preserved, suggesting that GSPE may be effective in preventing decreased enterohormone expression induced by aging.