☆ 4.7 Article

ZNF385A and ZNF346 Serve as Prognostic Biomarkers Associated with an Inflamed Immunosuppressive Tumor Microenvironment in Hepatocellular Carcinoma

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

Related references

Note: Only part of the references are listed.

Article Oncology

Cancer statistics, 2022

Rebecca L. Siegel et al.

Summary: Each year, the American Cancer Society compiles data on cancer occurrence and outcomes in the United States. The latest data shows that breast and prostate cancer progress has stagnated, while lung cancer has shown improvements in survival rates. Lung cancer incidence for advanced disease has declined while localized-stage rates have increased, resulting in higher survival rates. Mortality patterns align with incidence trends, with lung cancer deaths declining rapidly, breast cancer deaths slowing, and prostate cancer deaths stabilizing.

CA-A CANCER JOURNAL FOR CLINICIANS (2022)

Add to Collection

Article Oncology

Constitutive Activation of the Tumor Suppressor p53 in Hepatocytes Paradoxically Promotes Non-Cell Autonomous Liver Carcinogenesis

Yuki Makino et al.

Summary: This study reveals that activation of p53 in hepatocytes promotes liver carcinogenesis derived from HPCs, elucidating a paradoxical aspect of the tumor suppressor gene p53 and a novel mechanism of liver carcinogenesis.

CANCER RESEARCH (2022)

Add to Collection

Review Oncology

Emerging Therapies for Hepatocellular Carcinoma (HCC)

Eesha Chakraborty et al.

Summary: Primary liver cancer is a major global health challenge with a significant negative impact on patient survival. Conventional cancer treatments are often ineffective due to the resistance of liver cancer. This review explores new and advanced therapies, such as gene therapy and immunotherapy, as potential breakthroughs for more effective and safer treatment.

CANCERS (2022)

Add to Collection

Review Immunology

Molecular pathogenesis: Connections between viral hepatitis-induced and non-alcoholic steatohepatitis-induced hepatocellular carcinoma

Zelin Tian et al.

Summary: Hepatocellular carcinoma (HCC), caused by viral hepatitis, alcoholic, and non-alcoholic fatty liver disease (NAFLD), is the sixth most common cancer worldwide. Viral hepatitis accounts for 80% of HCC cases globally. NAFLD has become the most common liver disease and major risk factor for HCC in developed countries. This review discusses the specific and similar pathogenesis mechanisms of viral hepatitis-induced HCC and NAFLD-induced HCC, including viral proteins, genetic factors, epigenetic modifications, and abnormal lipid metabolism.

FRONTIERS IN IMMUNOLOGY (2022)

Add to Collection

Review Gastroenterology & Hepatology

Evolution of Systemic Therapy for Hepatocellular Carcinoma

Richard S. Finn et al.

Summary: In recent years, there has been a shift in focus towards novel drug development for hepatocellular carcinoma (HCC) with attention being given to immune-oncology approaches. While there have been significant advancements in phase 3 studies in advanced HCC, there is still a need to optimize patient selection criteria and combination strategies to fully utilize the potential of these approaches in clinical practice. The next generation of studies will aim to translate the enhanced understanding of tumor biology into improved clinical trial designs.

HEPATOLOGY (2021)

Add to Collection

Review Oncology

The Current Landscape of Immune Checkpoint Blockade in Hepatocellular Carcinoma: A Review

Matthias Pinter et al.

Summary: Recent advancements in the treatment of advanced hepatocellular carcinoma (HCC) have led to the approval of new systemic therapies such as angiogenesis inhibitors and immune checkpoint blockers, indicating important progress in the field. Strategies to target immunosuppression in tumors, such as vascular endothelial growth factor pathway inhibition and transforming growth factor-beta pathway inhibition, show promise in enhancing the efficacy of immunotherapy in HCC. Successes and failures of these treatments have provided insights into implementing novel systemic therapy in HCC and improving immunotherapy efficacy for this disease.

JAMA ONCOLOGY (2021)

Add to Collection

Article Medicine, General & Internal

Hepatocellular carcinoma

Josep M. Llovet et al.

Summary: Liver cancer, particularly hepatocellular carcinoma (HCC), poses a significant global health challenge with rising incidence projected to exceed 1 million cases by 2025. Infection by hepatitis B and C viruses remains a major risk factor for HCC, while non-alcoholic steatohepatitis is emerging as a more common risk factor in Western countries. Advances in systemic therapies for HCC, including immunotherapies and targeted therapies, are expected to revolutionize the management of this disease.

NATURE REVIEWS DISEASE PRIMERS (2021)

Add to Collection

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Add to Collection

Article Oncology

Integrated bioinformatics analyses of key genes involved in hepatocellular carcinoma immunosuppression

Hongyan Huang et al.

Summary: This study aimed to identify key genes involved in HCC immunosuppression and establish an innate immune risk signature through comprehensive bioinformatics analysis. The constructed signature may be used to predict a poor prognosis and potentially serve as an immunotherapeutic target for patients with HCC.

ONCOLOGY LETTERS (2021)

Add to Collection

Article Oncology

Exploring Markers of Exhausted CD8 T Cells to Predict Response to Immune Checkpoint Inhibitor Therapy for Hepatocellular Carcinoma

Chia-Lang Hsu et al.

Summary: Reversal of CD8 T-cell exhaustion is a key mechanism of anti-PD-1/PD-L1-based immune checkpoint inhibitor therapy for hepatocellular carcinoma (HCC). A 9-gene signature associated with T-cell exhaustion predicted better response to ICI therapy and improved survival outcomes. Patients with lung metastatic HCC may have higher response rates to ICI therapy.

LIVER CANCER (2021)

Add to Collection

Article Immunology

IOBR: Multi-Omics Immuno-Oncology Biological Research to Decode Tumor Microenvironment and Signatures

Dongqiang Zeng et al.

Summary: Recent advances in next-generation sequencing technologies have led to a rapid accumulation of publicly available multi-omics datasets. The development of IOBR as a computational tool aims to comprehensively interpret multi-omics data and facilitate immuno-oncology exploration for precision immunotherapy.

FRONTIERS IN IMMUNOLOGY (2021)

Add to Collection

Article Biology

MiR-542-3p suppresses neuroblastoma cell proliferation and invasion by downregulation of KDM1A and ZNF346

Qiang Wei et al.

OPEN LIFE SCIENCES (2020)

Add to Collection

Article Medicine, General & Internal

Atezolizumab plus Bevacizumab in Unresectable Hepatocellular Carcinoma

Richard S. Finn et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Add to Collection

Review Immunology

Regulation of PD-L1 Expression by NF-κB in Cancer

Fabrizio Antonangeli et al.

FRONTIERS IN IMMUNOLOGY (2020)

Add to Collection

Review Biochemistry & Molecular Biology

The Role of Fibrosis and Liver-Associated Fibroblasts in the Pathogenesis of Hepatocellular Carcinoma

Jacopo Baglieri et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Add to Collection

Review Medicine, General & Internal

Hepatocellular Carcinoma

Augusto Villanueva

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Add to Collection

Article Oncology

Combined Stereotactic Body Radiotherapy and Checkpoint Inhibition in Unresectable Hepatocellular Carcinoma: A Potential Synergistic Treatment Strategy

Chi-Leung Chiang et al.

FRONTIERS IN ONCOLOGY (2019)

Add to Collection

Review Oncology

The Role of Angiogenesis in Hepatocellular Carcinoma

Michael A. Morse et al.

CLINICAL CANCER RESEARCH (2019)

Add to Collection

Review Gastroenterology & Hepatology

Wnt-β-catenin signalling in liver development, health and disease

Maria J. Perugorria et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2019)

Add to Collection

Review Gastroenterology & Hepatology

Inflammation and Liver Cancer: Molecular Mechanisms and Therapeutic Targets

Yoon Mee Yang et al.

SEMINARS IN LIVER DISEASE (2019)

Add to Collection

Review Biochemistry & Molecular Biology

Understanding the tumor immune microenvironment (TIME) for effective therapy

Mikhail Binnewies et al.

NATURE MEDICINE (2018)

Add to Collection

Article Multidisciplinary Sciences

TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

Sanjeev Mariathasan et al.

NATURE (2018)

Add to Collection

Article Biochemistry & Molecular Biology

Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response

Peng Jiang et al.

NATURE MEDICINE (2018)

Add to Collection

Article Biology

MicroRNA-1247 inhibits cell proliferation by directly targeting ZNF346 in childhood neuroblastoma

Tingting Wu et al.

BIOLOGICAL RESEARCH (2018)

Add to Collection

Review Cell Biology

Regulatory T cells in cancer immunotherapy

Atsushi Tanaka et al.

CELL RESEARCH (2017)

Add to Collection

Letter Biotechnology & Applied Microbiology

Toil enables reproducible, open source, big biomedical data analyses

John Vivian et al.

NATURE BIOTECHNOLOGY (2017)

Add to Collection

Article Oncology

Myeloid-Derived Suppressor Cells

Dmitry I. Gabrilovich

CANCER IMMUNOLOGY RESEARCH (2017)

Add to Collection

Article Oncology

A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development

Yannick Boege et al.

CANCER CELL (2017)

Add to Collection

Review Biochemistry & Molecular Biology

Tumor-associated macrophages and anti-tumor therapies: complex links

Cristina Belgiovine et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2016)

Add to Collection

Review Cell Biology

Zinc finger proteins in cancer progression

Jayu Jen et al.

JOURNAL OF BIOMEDICAL SCIENCE (2016)

Add to Collection

Article Multidisciplinary Sciences

pRRophetic: An R Package for Prediction of Clinical Chemotherapeutic Response from Tumor Gene Expression Levels

Paul Geeleher et al.

PLOS ONE (2014)

Add to Collection

Article Cell Biology

RIP3 Inhibits Inflammatory Hepatocarcinogenesis but Promotes Cholestasis by Controlling Caspase-8-and JNK-Dependent Compensatory Cell Proliferation

Mihael Vucur et al.

CELL REPORTS (2013)

Add to Collection

Article Biochemical Research Methods

pROC: an open-source package for R and S plus to analyze and compare ROC curves

Xavier Robin et al.

BMC BIOINFORMATICS (2011)

Add to Collection

Review Cell Biology

NF-kappa B and STAT3 - key players in liver inflammation and cancer

Guobin He et al.

CELL RESEARCH (2011)

Add to Collection

Article Biochemistry & Molecular Biology

Cooperative Role of the RNA-Binding Proteins Hzf and HuR in p53 Activation

Hideaki Nakamura et al.

MOLECULAR AND CELLULAR BIOLOGY (2011)

Add to Collection

Article Hematology

JAZ mediates G1 cell-cycle arrest and apoptosis by positively regulating p53 transcriptional activity

Mingli Yang et al.

BLOOD (2006)

Add to Collection

Article Biochemistry & Molecular Biology

Hzf, a p53-responsive gene, regulates maintenance of the G(2) phase checkpoint induced by DNA damage

M Sugimoto et al.

MOLECULAR AND CELLULAR BIOLOGY (2006)

Add to Collection

Article Genetics & Heredity

RZF, a zinc-finger protein in the photoreceptors of human retina

S Sharma et al.

GENE (2004)

Add to Collection

Review Biochemistry & Molecular Biology

Three classes of C2H2 zinc finger proteins

S Iuchi

CELLULAR AND MOLECULAR LIFE SCIENCES (2001)

Add to Collection

© Peeref 2019-2024. All rights reserved.