4.7 Article

Relationship between GABA-Ergic System and the Expression of Mephedrone-Induced Reward in Rats-Behavioral, Chromatographic and In Vivo Imaging Study

Related references

Note: Only part of the references are listed.
Article Neurosciences

Moderate ethanol drinking is sufficient to alter Ventral Tegmental Area dopamine neurons activity via functional and structural remodeling of GABAergic transmission

A. Ilari et al.

Summary: Previous studies have shown that moderate ethanol drinking suppresses the spontaneous activity of VTA dopamine neurons while increasing their response to acute ethanol. Chronic ethanol consumption increases GABA input frequency and leads to rewiring of the GABA network in the VTA, potentially driving progression to addiction.

NEUROPHARMACOLOGY (2022)

Review Neurosciences

The neurobiology of drug addiction: cross-species insights into the dysfunction and recovery of the prefrontal cortex

Ahmet O. Ceceli et al.

Summary: Studies show that drug addiction leads to dysfunction in the prefrontal cortex, affecting emotions, cognition, and behavior control, and may result in deficits in reward-related decision-making. Additionally, chronic drug use causes damage to the prefrontal cortex, but recovery can occur after withdrawal, indicating plasticity in these brain regions and functions. The research also explores characteristics of drug classes, potential biomarkers, and treatment strategies.

NEUROPSYCHOPHARMACOLOGY (2022)

Article Neurosciences

The interactions of alcohol and cocaine regulate the expression of genes involved in the GABAergic, glutamatergic and endocannabinoid systems of male and female rats

Alberto Marcos et al.

Summary: This study investigates the effects of polyconsumption of cocaine and alcohol on neurotransmitter systems. The results show that cocaine and alcohol interact to affect the GABAergic and endocannabinoid systems, as well as the expression of synaptic scaffold proteins. These interactions differ between developmental stages and sexes.

NEUROPHARMACOLOGY (2022)

Article Behavioral Sciences

Baclofen and naltrexone, but not N-acetylcysteine, affect voluntary alcohol drinking in rats regardless of individual levels of alcohol intake

A. Maryse Minnaard et al.

Summary: Although there is individual variation in alcohol consumption, it does not predict the responsiveness to baclofen and naltrexone in rats. GABA(B) receptor agonist baclofen and opioid receptor antagonist naltrexone can reduce alcohol consumption, but cysteine precursor N-acetylcysteine does not have the same effect across different drinking rat subgroups. Individual variability in alcohol consumption and sensitivity to treatment likely involve distinct biological mechanisms.

BEHAVIOURAL PHARMACOLOGY (2021)

Article Biochemistry & Molecular Biology

GABAergic projections to the ventral tegmental area govern cocaine-conditioned reward

Moriya Weitz et al.

Summary: Through optogenetics, it was found that GABAergic inputs from the RMTg and NAc strongly inhibit GABA(A)-mediated IPSCs in VTA DA neurons following acute cocaine exposure. Exogenous light activation of these inputs during the acquisition of cocaine-CPP significantly reduced the rewarding properties of cocaine, indicating the critical role of these GABAergic inputs in modulating and potentially interrupting cocaine reward.

ADDICTION BIOLOGY (2021)

Article Pharmacology & Pharmacy

Pharmacology of Drugs Used as Stimulants

James R. Docherty et al.

Summary: The effects of psychostimulants involve various neurotransmitter pathways and can lead to serious adverse events, including potentially life-threatening hyperthermia. Recreational users should be aware of the dangers associated with these substances.

JOURNAL OF CLINICAL PHARMACOLOGY (2021)

Article Neurosciences

Insight into Glutamatergic Involvement in Rewarding Effects of Mephedrone in Rats: In Vivo and Ex Vivo Study

Olga Wronikowska et al.

Summary: This study comprehensively evaluated the involvement of glutamatergic transmission in the rewarding effects of mephedrone using behavioral studies, in vivo magnetic resonance spectroscopy, and ion-exchange chromatography. The results showed that memantine could reverse the rewarding effects of mephedrone, while MRS study demonstrated an increase in glutamate levels in the hippocampus after subchronic mephedrone administration. Ex vivo chromatographic analysis supported the findings of the MRS study, providing new insights into glutamatergic involvement in mephedrone's rewarding properties.

MOLECULAR NEUROBIOLOGY (2021)

Article Neurosciences

Vulnerability factors for mephedrone-induced conditioned place preference in rats-the impact of sex differences, social-conditioning and stress

Olga Wronikowska et al.

Summary: The study aimed to assess the impact of factors like sex differences, social conditioning, and chronic mild unpredictable stress on the liability to mephedrone-induced reward in rats. Results showed that mephedrone induced CPP in both male and female rats, with varying effects based on social conditioning and stress levels.

PSYCHOPHARMACOLOGY (2021)

Review Multidisciplinary Sciences

Molecular mechanisms of metabotropic GABAB receptor function

Hamidreza Shaye et al.

Summary: GABA(B) receptors play a crucial role in inhibitory neurotransmission in the brain, modulating neuronal signaling and being linked to various neurological disorders. Recent cryo-EM studies have provided detailed insights into the activation mechanism of GABA(B) receptors, offering potential for the discovery of new therapeutic drugs and neuromodulators. The structures of the receptor in different conformational states and bound to various ligands contribute to a comprehensive understanding of the receptor's activation process.

SCIENCE ADVANCES (2021)

Review Physiology

THE NEUROSCIENCE OF DRUG REWARD AND ADDICTION

Nora D. Volkow et al.

PHYSIOLOGICAL REVIEWS (2019)

Review Neurosciences

VTA GABA Neurons at the Interface of Stress and Reward

Chloe Bouarab et al.

FRONTIERS IN NEURAL CIRCUITS (2019)

Article Pharmacology & Pharmacy

Conditioned Reward of Opioids, but not Psychostimulants, is Impaired in GABA-A Receptor Subunit Knockout Mice

Milo S. Siivonen et al.

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2018)

Review Behavioral Sciences

Dopamine and reward: a view from the prefrontal cortex

Bolton K. H. Chau et al.

BEHAVIOURAL PHARMACOLOGY (2018)

Review Multidisciplinary Sciences

Diversity of structure and function of GABAB receptors: a complexity of GABAB-mediated signaling

Miho Terunuma

PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES (2018)

Review Rehabilitation

EFFICACY AND SAFETY OF ORAL BACLOFEN IN THE MANAGEMENT OF SPASTICITY: A RATIONALE FOR INTRATHECAL BACLOFEN

Per Ertzgaard et al.

JOURNAL OF REHABILITATION MEDICINE (2017)

Review Radiology, Nuclear Medicine & Medical Imaging

Edited 1H Magnetic Resonance Spectroscopy In Vivo: Methods and Metabolites

Ashley D. Harris et al.

MAGNETIC RESONANCE IN MEDICINE (2017)

Review Physiology

HIPPOCAMPAL GABAERGIC INHIBITORY INTERNEURONS

Kenneth A. Pelkey et al.

PHYSIOLOGICAL REVIEWS (2017)

Article Neurosciences

Effect of Some Psychoactive Drugs Used as 'Legal Highs' on Brain Neurotransmitters

Krystyna Goembiowska et al.

NEUROTOXICITY RESEARCH (2016)

Article Pharmacology & Pharmacy

Phase I metabolites of mephedrone display biological activity as substrates at monoamine transporters

F. P. Mayer et al.

BRITISH JOURNAL OF PHARMACOLOGY (2016)

Review Biochemistry & Molecular Biology

Hippocampal GABAergic transmission: a new target for adenosine control of excitability

Diogo M. Rombo et al.

JOURNAL OF NEUROCHEMISTRY (2016)

Article Clinical Neurology

Baclofen for alcohol dependence: Relationships between baclofen and alcohol dosing and the occurrence of major sedation

Benjamin Rolland et al.

EUROPEAN NEUROPSYCHOPHARMACOLOGY (2015)

Article Behavioral Sciences

Locomotor stimulant and discriminative stimulus effects of 'bath salt' cathinones

Michael B. Gatch et al.

BEHAVIOURAL PHARMACOLOGY (2013)

Article Pharmacology & Pharmacy

Comparative neuropharmacology of three psychostimulant cathinone derivatives: butylone, mephedrone and methylone

Raul Lopez-Arnau et al.

BRITISH JOURNAL OF PHARMACOLOGY (2012)

Article Clinical Neurology

Interaction of mephedrone with dopamine and serotonin targets in rats

Jose Martinez-Clemente et al.

EUROPEAN NEUROPSYCHOPHARMACOLOGY (2012)

Review Neurosciences

The Mysterious Motivational Functions of Mesolimbic Dopamine

John D. Salamone et al.

NEURON (2012)

Article Multidisciplinary Sciences

Organization of GABAergic Synaptic Circuits in the Rat Ventral Tegmental Area

Alessandro Ciccarelli et al.

PLOS ONE (2012)

Review Chemistry, Physical

In vivo magnetic resonance spectroscopy of GABA: A methodological review

Nicolaas A. J. Puts et al.

PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY (2012)

Article Biochemistry & Molecular Biology

The GABA-B positive modulator GS39783 decreases psychostimulant conditioned-reinforcement and conditioned-reward

Briac Halbout et al.

ADDICTION BIOLOGY (2011)

Article Pharmacology & Pharmacy

Positive modulation of GABAB receptors decreased nicotine self-administration and counteracted nicotine-induced enhancement of brain reward function in rats

Neil E. Paterson et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2008)

Article Substance Abuse

Baclofen antagonizes intravenous self-administration of nicotine in mice and rats

L Fattore et al.

ALCOHOL AND ALCOHOLISM (2002)

Review Substance Abuse

GABAB receptor agonists for the treatment of drug addiction:: a review of recent findings

MS Cousins et al.

DRUG AND ALCOHOL DEPENDENCE (2002)