Programmed death-ligand1 is a determinant of recurrence in alveolar echinococcosis

Article Biochemistry & Molecular Biology

The expression of PD-1 and its ligands increases in Leishmania infection and its blockade reduces the parasite burden

Abdollah Jafarzadeh et al.

Summary: The expression of PD-1 and its ligands increase in Leishmania infection and lead to immune suppression. Blocking PD-1/PD-L1 interaction can enhance immune response and reduce parasite burden, making it a potential therapeutic strategy.

CYTOKINE (2022)

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Article Immunology

Investigating new serological and tissue markers for the follow-up of patients operated for alveolar echinococcosis

Anne-Pauline Bellanger et al.

Summary: This study found PD-L1 to be a promising serological marker and further confirmed the performance of anti-Em18 serology. Further studies on a larger cohort are needed to confirm the utility of performing systematically microarray on resected liver tissue.

PARASITE IMMUNOLOGY (2021)

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Article Immunology

Innate and adaptive immune responses following PD-L1 blockade in treating chronic murine alveolar echinococcosis

Fadi Jebbawi et al.

Summary: The study demonstrated that PD-L1 blockade significantly reduced parasite load, promoted T-cell activity, restored antigen presenting cells, suppressed NK and NKT cells, and improved control of E. multilocularis infection.

PARASITE IMMUNOLOGY (2021)

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Review Oncology

Systematic Review of PD-1/PD-L1 Inhibitors in Oncology: From Personalized Medicine to Public Health

Elaine Chang et al.

Summary: PD-[L]1 inhibitors have shown to be effective anticancer therapy in a subset of patients, providing new treatment options for certain cancer types. However, the modest response rates in some cancers indicate a lack of understanding of the biology of these diseases, requiring further investigation to identify more appropriate patient populations.

ONCOLOGIST (2021)

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Review Oncology