4.7 Article

Pre-Omicron seroprevalence, seroconversion, and seroreversion of infection-induced SARS-CoV-2 antibodies among a cohort of children and teenagers in Montreal, Canada

Related references

Note: Only part of the references are listed.
Article Multidisciplinary Sciences

Robust and durable serological response following pediatric SARS-CoV-2 infection

Hanna Renk et al.

Summary: This study compares the humoral immune response in children and adults following SARS-CoV-2 infection and finds that children are more likely to have asymptomatic infections and higher levels of specific antibodies that persist for a longer time. Symptomatic and asymptomatic infections induce similar humoral responses across all age groups.

NATURE COMMUNICATIONS (2022)

Article Infectious Diseases

Presence of SARS-CoV-2 antibodies following COVID-19 diagnosis: a longitudinal study of patients at a major urgent care provider in New York

Emily Poehlein et al.

Summary: This study examined the duration of antibody persistence following natural infection with SARS-CoV-2. The findings showed that over 90% of individuals still had detectable levels of antibodies at 180 days post diagnosis, and the median duration of detectable antibodies following infection was 342 days. Age was found to have an impact on antibody persistence.

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE (2022)

Article Infectious Diseases

Seroprevalence of SARS-CoV-2 in German secondary schools from October 2020 to July 2021: a longitudinal study

Carolin Kirsten et al.

Summary: A study conducted in 14 secondary schools in eastern Saxony, Germany, shows that students and teachers are not overrepresented in SARS-CoV-2 infections during the second and third wave of the pandemic. The seroprevalence of antibodies increased during the lockdown period and the ratio of undetected to detected cases decreased over time. The study suggests that school closures may be ineffective in terms of pandemic control measures or individual risk reduction in children and adolescents.

INFECTION (2022)

Article Infectious Diseases

The REinfection in COVID-19 Estimation of Risk (RECOVER) study: Reinfection and serology dynamics in a cohort of Canadian healthcare workers

Etienne Racine et al.

Summary: Among unvaccinated healthcare workers, reinfection with SARS-CoV-2 following a primary infection remained rare. The duration of seropositivity was significantly longer in symptomatic individuals compared to asymptomatic ones.

INFLUENZA AND OTHER RESPIRATORY VIRUSES (2022)

Article Public, Environmental & Occupational Health

Seroprevalence of Infection-Induced SARS-CoV-2 Antibodies — United States, September 2021–February 2022

Kristie E.N. Clarke et al.

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2022)

Article Multidisciplinary Sciences

Comparison of antibody responses to SARS-CoV-2 variants in Australian children

Zheng Quan Toh et al.

Summary: This study compares antibody responses in unvaccinated Australian children across three SARS-CoV-2 variants. The findings show that children infected with the Omicron variant exhibit lower antibody levels and function compared to those infected with the Wuhan or Delta variants, as well as vaccinated children with breakthrough Omicron infection. These results have important implications for public health measures and vaccination strategies to protect children.

NATURE COMMUNICATIONS (2022)

Article Medicine, General & Internal

Long-term Immune Response to SARS-CoV-2 Infection Among Children and Adults After Mild Infection

Costanza Di Chiara et al.

Summary: This study examined the long-term immune response of children to SARS-CoV-2 infection and found that children have higher antibody titers compared to adults. The antibodies can persist for up to 10 months after infection. This has important implications for optimizing COVID-19 vaccination strategies.

JAMA NETWORK OPEN (2022)

Article Multidisciplinary Sciences

Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection

Jennifer M. Dan et al.

Summary: Different components of immune memory to SARS-CoV-2 exhibit distinct kinetics, with antibodies and spike-specific memory B cells remaining relatively stable over 6 months, while CD4(+) T cells and CD8(+) T cells declining with a half-life of 3 to 5 months after infection.

SCIENCE (2021)

Article Medicine, General & Internal

Clustering and longitudinal change in SARS-CoV-2 seroprevalence in school children in the canton of Zurich, Switzerland: prospective cohort study of 55 schools

Agne Ulyte et al.

Summary: This study examined longitudinal changes in SARS-CoV-2 seroprevalence and clustering of seropositive children in schools in Zurich, Switzerland from June to November 2020. The overall seroprevalence increased during this period, with varying rates across districts. The clustering of seropositive children was observed in only a few classes, indicating that with schools open and preventive measures in place, transmission of SARS-CoV-2 among children was limited despite community transmission.

BMJ-BRITISH MEDICAL JOURNAL (2021)

Article Infectious Diseases

Duration of SARS-CoV-2 sero-positivity in a large longitudinal sero-surveillance cohort: the COVID-19 Community Research Partnership

David M. Herrington et al.

Summary: This study found that approximately 50% of participants with SARS-CoV-2 infection but minimal or no symptoms experienced antibody reversion within 30 days of their initial positive test. IgM reverted more quickly than IgG. Overall, the duration of antibody response was short.

BMC INFECTIOUS DISEASES (2021)

Article Infectious Diseases

Persistence of anti-SARS-CoV-2 antibodies: immunoassay heterogeneity and implications for serosurveillance

Javier Perez-Saez et al.

Summary: This study aimed to quantify the sensitivity of three commercially available SARS-CoV-2 immunoassays in detecting historic infections, with the EuroImmun assay missing 40% of infections after 9 months. Inappropriately accounting for time-varying assay sensitivity may lead to biased serosurvey estimates. Appropriate adjustment of assay performance is crucial for interpreting serological studies in the case of diminishing sensitivity after infection.

CLINICAL MICROBIOLOGY AND INFECTION (2021)

Article Infectious Diseases

Emergence of SARS-CoV-2 Alpha (B.1.1.7) variant, infection rates, antibody seroconversion and seroprevalence rates in secondary school students and staff: Active prospective surveillance, December 2020 to March 2021, England

Shamez N. Ladhani et al.

Summary: By March 2021, 5.6% of students and 4.4% of staff had laboratory-confirmed SARS-CoV-2 infection from December 2020-March 2021. One third of students and staff had evidence of prior infection based on N-antibody seropositivity, and an additional third of staff had evidence of vaccine-induced immunity based on S-antibody seropositivity.

JOURNAL OF INFECTION (2021)

Article Multidisciplinary Sciences

Does school reopening affect SARS-CoV-2 seroprevalence among school-age children in Milan?

Lucia Barcellini et al.

Summary: The study in Milan found a low seroprevalence rate among school children from September 2020 to January 2021, with no significant differences between students attending school in person and those switched to remote learning. The data suggest that schools do not amplify the transmission of SARS-CoV-2 but rather reflect the level of transmission in the community.

PLOS ONE (2021)

Article Immunology

Detection of SARS-CoV-2 antibodies formed in response to the BNT162b2 and mRNA-1237 mRNA vaccine by commercial antibody tests

Jamil N. Kanji et al.

Summary: This study found that commercial assays can detect vaccine-induced antibodies after COVID-19 vaccination, and the levels of these antibodies increase over time. Neutralizing antibodies can be detected at all timepoints post-vaccination and show an increasing trend over time.

VACCINE (2021)

Article Medicine, General & Internal

Seroprevalence of anti-SARS-CoV-2 antibodies among school and daycare children and personnel: protocol for a cohort study in Montreal, Canada

Kate Zinszer et al.

Summary: The EnCORE study aims to estimate the seroprevalence and seroconversion of SARS-CoV-2 among school and daycare children and personnel, as well as examine associations with sociodemographic characteristics, COVID-19 symptoms, tests, and changes in health and lifestyle outcomes. This research will provide valuable insights into SARS-CoV-2 transmission dynamics in educational settings and will be disseminated to various stakeholders in the form of results.

BMJ OPEN (2021)

Article Medicine, Research & Experimental

Neutralising SARS-CoV-2 RBD-specific antibodies persist for at least six months independently of symptoms in adults

Angelika Wagner et al.

Summary: A large-scale testing system for virus-specific and neutralising antibodies was set up at the beginning of the SARS-CoV-2 pandemic in Europe in spring 2020. Analysis of sera from 1655 adult employees revealed that approximately 10.15% had SARS-CoV-2-specific antibodies, with RBD-specific antibodies persisting for up to six months and correlating closely with virus neutralisation.

COMMUNICATIONS MEDICINE (2021)

Article Biochemistry & Molecular Biology

Antibody responses to SARS-CoV-2 in patients with COVID-19

Quan-Xin Long et al.

NATURE MEDICINE (2020)