Killer cell immunoglobulin-like receptor three domains long cytoplasmic tail 1 gene 007 may modulate disease progression of human immunodeficiency virus-1 infection in the Japanese population

One of the KIR allele, KIR3DL1*007, was associated with the progression to acquired immunodeficiency syndrome and not with the susceptibility to HIV-1 infection in the Japanese and Indian populations, implying that KIR3DL1*007-positive NK cells might eliminate HIV-infected cells less effectively than NK cells bearing the other KIR3DL1 alleles or KIR3DS1 alleles.

Automated summary

KIR3DL1*007 allele is linked to the progression of acquired immunodeficiency syndrome but not to the susceptibility to HIV-1 infection. This suggests that NK cells with KIR3DL1*007 might eliminate HIV-infected cells less effectively compared to NK cells carrying other KIR3DL1 or KIR3DS1 alleles.