Journal
INTERNATIONAL JOURNAL OF IMMUNOGENETICS
Volume 50, Issue 2, Pages 48-52Publisher
WILEY
DOI: 10.1111/iji.12617
Keywords
HIV-1; KIR3DL1; NK receptors
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KIR3DL1*007 allele is linked to the progression of acquired immunodeficiency syndrome but not to the susceptibility to HIV-1 infection. This suggests that NK cells with KIR3DL1*007 might eliminate HIV-infected cells less effectively compared to NK cells carrying other KIR3DL1 or KIR3DS1 alleles.
One of the KIR allele, KIR3DL1*007, was associated with the progression to acquired immunodeficiency syndrome and not with the susceptibility to HIV-1 infection in the Japanese and Indian populations, implying that KIR3DL1*007-positive NK cells might eliminate HIV-infected cells less effectively than NK cells bearing the other KIR3DL1 alleles or KIR3DS1 alleles.
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