Oleanolic acid suppresses pentylenetetrazole-induced seizure in vivo

The aim of this study was to investigate the protective effects of triterpene oleanolic acid on the brain tissue of mice with pentylenetetrazole (PTZ)-induced epileptic seizures. Male Swiss albino mice were randomly separated into five groups as the PTZ, control, and oleanolic acid (10, 30, and 100 mg/kg) groups. PTZ injection was seen to cause significant seizures compared with the control group. Oleanolic acid significantly prolonged the latency to onset of myoclonic jerks and the duration of clonic convulsions, and decreased mean seizure scores following PTZ administration. Pretreatment with oleanolic acid also led to an increase in antioxidant enzyme activity (CAT and AChE) and levels (GSH and SOD) in the brain. The data obtained from this study support oleanolic acid may have anticonvulsant potential in PTZ-induced seizures, prevent oxidative stress and protect against cognitive disturbances. These results may provide useful information for the inclusion of oleanolic acid in epilepsy treatment.

Automated summary

The aim of this study was to investigate the protective effects of triterpene oleanolic acid on mice brain tissue with PTZ-induced epileptic seizures. PTZ injection caused significant seizures, but oleanolic acid treatment prolonged seizure onset latency and duration, and decreased seizure scores. Oleanolic acid also increased antioxidant enzyme activity and levels in the brain. These findings suggest that oleanolic acid may have anticonvulsant potential and protect against oxidative stress and cognitive disturbances in PTZ-induced seizures.