Prevalence and prognostic impact of the coexistence of cachexia and sarcopenia in older patients with heart failure

Background: No study with an adequate patients' number has examined the relationship/overlap between sar-copenia and cachexia. We examined the prevalence of the overlap and prognostic implications of sarcopenia and cachexia in older patients with heart failure using well-accepted definitions. Methods: This was a post-hoc sub-analysis of the FRAGILE-HF study, a prospective, multicenter, observational study conducted at 15 hospitals in Japan. In total, 905 hospitalized older patients were classified into four groups based on the presence or absence of cachexia and/or sarcopenia, which were defined according to the Evans and Asian Working Group for Sarcopenia criteria revised in 2019, respectively. The primary endpoint was 2-year all -cause mortality.

Automated summary

This study examined the relationship between sar-copenia and cachexia in older patients with heart failure, and found that there is an overlap between these two conditions and they have prognostic implications. This study is of great importance for understanding the relevant diseases in patients with heart failure.