Pregnancy outcomes of women with Eisenmenger syndrome: A single-center study

Background: To explore the outcomes of mothers with Eisenmenger syndrome (ES) and their offspring.Methods: Pregnant women with ES admitted to the Beijing Anzhen Hospital between 2010 and 2019 were retrospectively analyzed and followed up.Results: Forty-two parturient women with ES were recruited, with an average age of 26.7 years (standard de-viation [SD], +/- 4.0 years). The average gestational age was 33.7 weeks (SD, +/- 2.5 weeks). The average percu-taneous oxygen saturation was 84.1 (+/- 9.2), and 40 (95.2%) had caesarean delivery. The average pulmonary artery systolic pressure was 107.5 mmHg (SD, +/- 20.3 mmHg). Twelve (28.6%) women experienced pulmonary hypertensive crisis; 11 (26.2%) of these women died. Regarding the offspring, the average fetal weight was 1778.1 g (SD, +/- 555.3 g), six (14.3%) died, and congenital heart disease was diagnosed in three (7.1%). There were significant differences in age, gestational age, percutaneous oxygen saturation, Apgar score, and heart failure between the maternal death and non-death groups (P < 0.05). Death was mainly related to pulmonary hypertensive crisis and heart failure.Conclusions: We recommend pregnancy termination if ES occurs during early pregnancy; however, patients should be informed of the risks if it occurs during late pregnancy. Multidisciplinary cooperation should be strengthened to improve the prognosis of the mothers and their offspring.

Automated summary

This study retrospectively analyzed and followed up on pregnant women with Eisenmenger syndrome (ES) admitted to Beijing Anzhen Hospital between 2010 and 2019 to explore the outcomes of the mothers and their offspring. The study found significant differences in age, gestational age, percutaneous oxygen saturation, Apgar score, and heart failure between the maternal death and non-death groups. The study recommends pregnancy termination if ES occurs during early pregnancy and highlights the importance of multidisciplinary cooperation to improve the prognosis of the mothers and their offspring.