Journal
INTERNATIONAL JOURNAL OF CANCER
Volume 153, Issue 4, Pages 709-722Publisher
WILEY
DOI: 10.1002/ijc.34464
Keywords
immune checkpoint inhibitors; drug resistance; colorectal cancer; mechanism; treatment
Categories
Ask authors/readers for more resources
Immunotherapy, particularly immune checkpoint inhibitors (ICIs), offers hope for patients with failed multiline therapy in cancer treatment. However, the benefit is limited to a small subset of patients with microsatellite instability-high (MSI-H) or mismatch repair-deficient (dMMR) metastatic colorectal cancer (mCRC). Resistance to ICIs is observed in 45-60% of dMMR/MSI-H mCRC patients, indicating potential unknown pathways mediating immune escape. Mismatch repair-proficient (pMMR) or microsatellite-stable (MSS) mCRC patients do not benefit from ICIs. This review discusses the mechanisms of action and current status of ICIs in CRC, as well as the mechanisms of primary and acquired resistance and potential therapeutic strategies to overcome resistance in the clinic.
Immunotherapy, especially with immune checkpoint inhibitors (ICIs), has shown advantages in cancer treatment and is a new hope for patients who have failed multiline therapy. However, in colorectal cancer (CRC), the benefit is limited to a small subset of patients with microsatellite instability-high (MSI-H) or mismatch repair-deficient (dMMR) metastatic CRC (mCRC). In addition, 45% to 60% of dMMR/MSI-H mCRC patients showed primary or acquired resistance to ICIs. This means that these patients may have potential unknown pathways mediating immune escape. Almost all mismatch repair-proficient (pMMR) or microsatellite-stable (MSS) mCRC patients do not benefit from ICIs. In this review, we discuss the mechanisms of action of ICIs and their current status in CRC. We then discuss the mechanisms of primary and acquired resistance to ICIs in CRC. Finally, we discuss promising therapeutic strategies to overcome resistance to ICIs in the clinic.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available