4.7 Article

Unveiling the epigenomic mechanisms of acquired platinum-resistance in high-grade serous ovarian cancer

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Aberrant Methylation of 20 miRNA Genes Specifically Involved in Various Steps of Ovarian Carcinoma Spread: From Primary Tumors to Peritoneal Macroscopic Metastases

Vitaly I. Loginov et al.

Summary: This study aimed to differentiate aberrantly methylated miRNA genes involved in different stages of ovarian carcinoma (OvCa) development and metastasis using methylation-specific qPCR. The results revealed distinct patterns of methylation and expression levels of miRNA genes during the progression and metastasis of OvCa, with some miRNA genes showing a significant association with poor overall survival of patients.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Oncology

DNA methylation and transcriptomic features are preserved throughout disease recurrence and chemoresistance in high grade serous ovarian cancers

Nicole Gull et al.

Summary: Global DNA methylation may not play a significant role in recurrence and chemoresistance of high grade serous ovarian cancer (HGSOC). The methylation and gene expression programs established in the primary tumor are conserved throughout the progression of the disease.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2022)

Article Biotechnology & Applied Microbiology

miR-182-5p Inhibits NKAPL Expression and Promotes the Proliferation of Osteosarcoma

Shen Yang et al.

Summary: The study revealed that low expression of NKAPL in osteosarcoma is correlated with tumor metastasis, size, and clinical stage. miR-182-5p targets NKAPL to inhibit its expression, promoting tumor proliferation through regulating the Notch signaling pathway and cell cycle progression.

BIOTECHNOLOGY AND BIOPROCESS ENGINEERING (2021)

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Review Genetics & Heredity

Epigenetic signatures in cancer: proper controls, current challenges and the potential for clinical translation

Daniela Mancarella et al.

Summary: Epigenetic alterations are associated with various diseases, including cancer, driven by genetic mutations and changes in global epigenetic signatures. Recent studies suggest that cancer epigenomes are mainly influenced by pre-existing epigenetic patterns in the cell-of-origin, calling for a redefinition of tumor-specific epigenetic changes.

GENOME MEDICINE (2021)

Article Oncology

Single-cell dissection of cellular components and interactions shaping the tumor immune phenotypes in ovarian cancer

Milena Hornburg et al.

Summary: This study provides a detailed analysis of distinct T cell infiltration patterns in ovarian tumors, revealing the impact on responses to cancer immunotherapies and the underlying key determinants and biology of tumor immune phenotypes. The research highlights potential molecular mechanisms shaping these phenotypes and may inform therapeutic strategies for enhancing clinical benefit from cancer immunotherapies.

CANCER CELL (2021)

Article Oncology

Longitudinal analysis of individual cfDNA methylome patterns in metastatic prostate cancer

Romina Silva et al.

Summary: This study investigated the dynamics of personal DNA methylomic profiles of metastatic prostate cancer patients during disease progression and therapy administration. Longitudinal assessment of cfDNA methylation revealed dynamic patterns associated with disease progression and therapy administration, highlighting the potential of using liquid biopsies to study prostate cancer evolution at a methylomic level.

CLINICAL EPIGENETICS (2021)

Article Multidisciplinary Sciences

clusterProfiler 4.0: A universal enrichment tool for interpreting omics data

Tianzhi Wu et al.

Summary: The updated version of clusterProfiler 4.0 is a powerful tool for functional enrichment analysis in a wide range of organisms, offering tidy interfaces for data operation and visualization, as well as new features like gene set enrichment analysis and comparison of results from multiple gene lists.

INNOVATION (2021)

Review Oncology

The untapped potential of ascites in ovarian cancer research and treatment

Caroline Elizabeth Ford et al.

BRITISH JOURNAL OF CANCER (2020)

Article Multidisciplinary Sciences

A decade of immune-checkpoint inhibitors in cancer therapy

Caroline Robert

NATURE COMMUNICATIONS (2020)

Review Biochemistry & Molecular Biology

High-Grade Serous Ovarian Cancer: Basic Sciences, Clinical and Therapeutic Standpoints

Michael-Antony Lisio et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Multidisciplinary Sciences

Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma

Olga Kondrashova et al.

NATURE COMMUNICATIONS (2018)

Article Multidisciplinary Sciences

Identification and characterization of TP53 gene Allele Dropout in Li-Fraumeni syndrome and Oral cancer cohorts

Mohammed Moquitul Haque et al.

SCIENTIFIC REPORTS (2018)

Article Multidisciplinary Sciences

High grade serous ovarian carcinomas originate in the fallopian tube

S. Intidhar Labidi-Galy et al.

NATURE COMMUNICATIONS (2017)

Article Multidisciplinary Sciences

DNA methylation and Transcriptome Changes Associated with Cisplatin Resistance in Ovarian Cancer

Riikka J. Lund et al.

SCIENTIFIC REPORTS (2017)

Article Biochemical Research Methods

missMethyl: an R package for analyzing data from Illumina's HumanMethylation450 platform

Belinda Phipson et al.

BIOINFORMATICS (2016)

Article Biotechnology & Applied Microbiology

Targeted DNA demethylation in vivo using dCas9-peptide repeat and scFv-TET1 catalytic domain fusions

Sumiyo Morita et al.

NATURE BIOTECHNOLOGY (2016)

Article Multidisciplinary Sciences

Whole-genome characterization of chemoresistant ovarian cancer

Ann-Marie Patch et al.

NATURE (2015)

Article Biochemistry & Molecular Biology

limma powers differential expression analyses for RNA-sequencing and microarray studies

Matthew E. Ritchie et al.

NUCLEIC ACIDS RESEARCH (2015)

Article Genetics & Heredity

De novo identification of differentially methylated regions in the human genome

Timothy J. Peters et al.

EPIGENETICS & CHROMATIN (2015)

Review Reproductive Biology

Notch signaling in serous ovarian cancer

Jolijn W. Groeneweg et al.

JOURNAL OF OVARIAN RESEARCH (2014)

Article Biotechnology & Applied Microbiology

DNA methylome profiling of human tissues identifies global and tissue-specific methylation patterns

Kaie Lokk et al.

GENOME BIOLOGY (2014)

Article Multidisciplinary Sciences

Signatures of mutational processes in human cancer

Ludmil B. Alexandrov et al.

NATURE (2013)

Article Multidisciplinary Sciences

Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA

Muhammed Murtaza et al.

NATURE (2013)

Article Genetics & Heredity

An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers

Steven A. Roberts et al.

NATURE GENETICS (2013)

Article Multidisciplinary Sciences

Evaluating cell lines as tumour models by comparison of genomic profiles

Silvia Domcke et al.

NATURE COMMUNICATIONS (2013)

Review Microbiology

Intrinsic immunity against retrotransposons by APOBEC cytidine deaminases

Atsushi Koito et al.

FRONTIERS IN MICROBIOLOGY (2013)

Article Biochemistry & Molecular Biology

BRCA1 epigenetic inactivation predicts sensitivity to platinum-based chemotherapy in breast and ovarian cancer

Olafur A. Stefansson et al.

EPIGENETICS (2012)

Article Multidisciplinary Sciences

Integrated genomic analyses of ovarian carcinoma

D. Bell et al.

NATURE (2011)

Article Biochemistry & Molecular Biology

Primer design versus PCR bias in methylation independent PCR amplifications

Tomasz K. Wojdacz et al.

EPIGENETICS (2009)

Article Biochemical Research Methods

Reversal of PCR bias for improved sensitivity of the DNA methylation melting curve assay

Tomasz K. Wojdacz et al.

BIOTECHNIQUES (2006)