Chitosan-based multifunctional hydrogel for sequential wound inflammation elimination, infection inhibition, and wound healing

In this study, a composite hydrogel (QMPD hydrogel) composed of methacrylate anhydride (MA) grafted qua-ternary ammonium chitosan (QCS-MA), polyvinylpyrrolidone (PVP), and dopamine (DA) was designed for the sequential wound inflammation elimination, infection inhibition, and wound healing. The QMPD hydrogel formation was initiated by the ultraviolet light-triggered polymerization of QCS-MA. Furthermore, hydrogen bonds, electrostatic interactions, and pi-pi stacking between QCS-MA, PVP, and DA were involved in the hydrogel formation. In this hydrogel, the quaternary ammonium groups of quaternary ammonium chitosan and the photothermal conversion of polydopamine are capable of killing bacteria on wounds, which showed the bacteriostatic ratios of 85.6 % and 92.5 % toward Escherichia coli and Staphylococcus aureus, respectively. Moreover, the oxidation of DA sufficiently scavenged free radicals and introduced the QMPD hydrogel with good anti-oxidant and anti-inflammatory abilities. Together with the extracellular matrix-mimic tropical structure, the QMPD hydrogel significantly promoted the wound management of mice. Therefore, the QMPD hydrogel is ex-pected to provide a new method for the design of wound healing dressings.

Automated summary

A composite hydrogel called QMPD hydrogel, composed of QCS-MA, PVP, and DA, was developed for wound healing. The hydrogel formation is triggered by ultraviolet light and involves hydrogen bonds, electrostatic interactions, and pi-pi stacking. The hydrogel exhibits bacteriostatic and anti-inflammatory properties, promoting wound management in mice.