Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 236, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2023.123913
Keywords
Chitosan; Cross -linking; Polysaccharide
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In this study, a series of dialdehyde derivatives of polysaccharides (DADPs) were prepared by oxidizing polysaccharides, and their biocompatibility and cross-linking properties were tested using chitosan as a model macromolecule. The results showed that the DADPs exhibited outstanding cross-linking and gelation properties comparable to glutaraldehyde (GA) and genipin (GP), and they also demonstrated excellent cytocompatibility and hemocompatibility with different concentrations.
Dialdehyde-based cross-linking agents are widely used in the cross-linking of amino group-containing macromolecules. However, the most commonly used cross-linking agents, glutaraldehyde (GA) and genipin (GP), have safety issues. In this study, a series of dialdehyde derivatives of polysaccharides (DADPs) were prepared by oxidation of polysaccharides, and their biocompatibility and cross-linking properties were tested using chitosan as a model macromolecule. The DADPs showed outstanding cross-linking and gelation properties comparable to GA and GP. The DADPs and hydrogels cross-linked with the DADPs exhibited excellent cytocompatibility and hemocompatibility with different concentrations while significant cytotoxicity was observed in GA and GP. The experimental results showed that the cross-linking effect of DADPs increased along with their oxidation degree. The outstanding cross-linking effect of the DADPs show a potential for use in the cross-linking of biomacromolecules with amino groups and could be an adequate alternative to existing cross-linkers.
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