Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 239, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2023.124351
Keywords
Astragalus polysaccharide; ERK signaling pathway; Satellite cell; MiR-133a; Sheep
Ask authors/readers for more resources
This study reveals that Astragalus polysaccharide (APS) promotes the differentiation of sheep skeletal muscle satellite cells (SMSCs) by regulating miR-133a through the MAPK/ERK signaling pathway. This finding is of great significance for understanding the role of APS in the development of sheep skeletal muscle.
Astragalus polysaccharide (APS) possesses extensive biological activities, pharmacological effects, and anti -fatigue function. MiR-133a is a specifically expressed miRNA in skeletal muscle that participates in the regu-lation of myoblast proliferation and differentiation. However, little is known about the role of APS in the development of sheep skeletal muscle. In this study, we aimed to investigate the underlying mechanism of APS and miR-133a on the differentiation of sheep skeletal muscle satellite cells (SMSCs) and the regulatory rela-tionship between APS and miR-133a. The results suggested that APS plays a positive regulatory role in the proliferation and differentiation of sheep SMSCs. Moreover, miR-133a significantly promotes SMSC differenti-ation and the activity of the MAPK/ERK signaling pathway. Importantly, we found that APS function requires the mediation of miR-133a in the differentiation of sheep SMSCs. Taken together, our results indicate that APS accelerates SMSC differentiation by regulating miR-133a via the MAPK/ERK signaling pathway in sheep.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available