Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 234, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2023.123674
Keywords
Hydrogels; Gamma irradiation; Poly(vinyl pyrrolidone); Sodium alginate; Ag NPs; Prednisolone drug; Drug delivery
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Nanocomposite hydrogels were prepared by gamma-radiation copolymerization of poly (vinyl pyrrolidone) (PVP)/sodium alginate (AG) in the presence of silver nanoparticles (Ag NPs). The effect of irradiation dose and Ag NPs content on the gel content and swelling characters of PVP/AG/Ag NPs copolymers was investigated. In addition, the structure-property behavior of the copolymers was characterized by IR spectroscopy, thermogravimetric analysis (TGA) and x-ray diffraction (XRD). The drug uptake-release characters of PVP/AG/silver NPs copolymers, taking Prednisolone as a model drug, were studied. The study showed that the appropriate dose of gamma irradiation to achieve homogeneous nanocomposites hydrogel films and the highest swelling in water was 30 kGy, regardless of composition. The introduction of Ag NPs up to 5 wt % improved the physical properties and enhanced the drug uptake-release characters.
Nanocomposite hydrogels were prepared by gamma-radiation copolymerization of poly (vinyl pyrrolidone) (PVP)/sodium alginate (AG) in the presence of silver nanoparticles (Ag NPs). The effect of irradiation dose and Ag NPs content on the gel content and swelling characters of PVP/AG/Ag NPs copolymers was investigated. In addition, the structure-property behavior of the copolymers was characterized by IR spectroscopy, thermogravimetric analysis (TGA) and x-ray diffraction (XRD). The drug uptake-release characters of PVP/AG/silver NPs copolymers, taking Prednisolone as a model drug, were studied. The study showed that the appropriate dose of gamma irradiation to achieve homogeneous nanocomposites hydrogel films and the highest swelling in water was 30 kGy, regardless of composition. The introduction of Ag NPs up to 5 wt % improved the physical properties and enhanced the drug uptake-release characters.
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