☆ 4.7 Article

Quantification of Plasmodium falciparum HRP-2 as an alternative method to [3H]hypoxanthine incorporation to measure the parasite reduction ratio in vitro

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2023)

Related references

Note: Only part of the references are listed.

Article Chemistry, Medicinal

The Parasite Reduction Ratio (PRR) Assay Version 2: Standardized Assessment of Plasmodium falciparum Viability after Antimalarial Treatment In Vitro

Annabelle Walz et al.

Summary: As artemisinin-resistant malaria parasites continue to emerge in Africa, the demand for new antimalarial drugs remains high. This study introduces the development of a version 2 (V2) assay, called the in vitro parasite reduction ratio (PRR) assay, which can effectively measure viable parasites with high sensitivity. It provides valuable pharmacodynamic parameters that can be used in pharmacokinetic/pharmacodynamic models, aiding in lead selection, optimization, and dose prediction.

PHARMACEUTICALS (2023)

Add to Collection

Article Immunology

Boromycin has Rapid-Onset Antibiotic Activity Against Asexual and Sexual Blood Stages of Plasmodium falciparum

Lais Pessanha de Carvalho et al.

Summary: Boromycin is a boron-containing macrolide antibiotic that is highly potent against certain viruses, bacteria, and protozoan parasites. It shows strong antiplasmodial activity against different types of Plasmodium species, including multidrug-resistant strains. Boromycin is a promising candidate for antimalarial treatment.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)

Add to Collection

Article Chemistry, Medicinal

Discovery and Preclinical Pharmacology of INE963, a Potent and Fast-Acting Blood-Stage Antimalarial with a High Barrier to Resistance and Potential for Single-Dose Cures in Uncomplicated Malaria

Benjamin R. Taft et al.

Summary: A highly potent antimalarial compound, INE963 (1), with favorable pharmacological properties, has been identified through high-throughput screening and shows potential for curing uncomplicated malaria.

JOURNAL OF MEDICINAL CHEMISTRY (2022)

Add to Collection

Article Biology

Artemisinin resistance in the malaria parasite, Plasmodium falciparum, originates from its initial transcriptional response

Lei Zhu et al.

Summary: This study identified a specific transcriptional profile associated with artemisinin resistance and revealed the complex genetic basis for this adaptive response through transcriptomic analysis.

COMMUNICATIONS BIOLOGY (2022)

Add to Collection

Article Microbiology

Parasite Viability as a Measure of In Vivo Drug Activity in Preclinical and Early Clinical Antimalarial Drug Assessment

Georges F. R. Radohery et al.

Summary: This study investigates the impact of artesunate on the viability of Plasmodium faciparum in humans and mice. The results show that artesunate leads to a faster decline in parasite viability compared to parasitemia. Higher concentrations of artesunate also result in faster parasite elimination. Predictions of infection recrudescence can be accurately made based on measures of parasite viability.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2022)

Add to Collection

Article Microbiology

New In Vitro Interaction-Parasite Reduction Ratio Assay for Early Derisk in Clinical Development of Antimalarial Combinations

Sebastian G. Wicha et al.

Summary: This study developed a novel in vitro-in silico combination approach to predict the pharmacodynamic interactions of antimalarial drug combinations. It successfully predicted the endpoints of clinical trials and provided additional insights into pharmacodynamic drug interactions.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2022)

Add to Collection

Article Chemistry, Medicinal

Discovery and Characterization of Potent, Efficacious, Orally Available Antimalarial Plasmepsin X Inhibitors and Preclinical Safety Assessment of UCB7362

Martin A. . Lowe et al.

Summary: This study optimized Plasmepsin X (PMX) and identified potent PMX inhibitors with potential efficacy in treating malaria.

JOURNAL OF MEDICINAL CHEMISTRY (2022)

Add to Collection

Article Chemistry, Medicinal

3-Hydroxy-propanamidines, a New Class of Orally Active Antimalarials Targeting Plasmodium falciparum

Tanja C. Knaab et al.

Summary: 3-Hydroxypropanamidines are a promising new class of highly active antiplasmodial agents, with compound 22 exhibiting excellent activity against chloroquine-sensitive and multidrug-resistant strains of Plasmodium falciparum in vitro, as well as low cytotoxicity. In vivo, 22 showed strong activity in mouse models, with a quick onset of action and high barrier to resistance, inhibiting heme detoxification machinery in the parasite.

JOURNAL OF MEDICINAL CHEMISTRY (2021)

Add to Collection

Article Chemistry, Medicinal

Repositioning and Characterization of 1-(Pyridin-4-yl)pyrrolidin-2-one Derivatives as Plasmodium Cytoplasmic Prolyl-tRNA Synthetase Inhibitors

Masanori Okaniwa et al.

Summary: The study identified a novel antimalarial scaffold with potential for prophylactic use, but has a high propensity for resistance development in vitro.

ACS INFECTIOUS DISEASES (2021)

Add to Collection

Article Medicine, General & Internal

Evidence of Artemisinin-Resistant Malaria in Africa

Betty Balikagala et al.

Summary: Research conducted in Northern Uganda revealed the emergence of artemisinin-resistant Plasmodium falciparum strains, with predominant mutations found in the kelch13 gene. Thirteen patients were infected with P. falciparum parasites carrying mutations in the A675V or C469Y allele, which were associated with prolonged parasite clearance half-lives.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Add to Collection

Article Cell Biology

The antimalarial MMV688533 provides potential for single-dose cures with a high barrier to Plasmodium falciparum parasite resistance

James M. Murithi et al.

Summary: MMV688533 is a novel antimalarial candidate that exhibits fast parasite clearance and low propensity for resistance in preclinical studies, showing potential for single low-dose cure for malaria. The compound targets proteins involved in intracellular trafficking, lipid utilization, and endocytosis, presenting a distinct mode of action compared to known antimalarials.

SCIENCE TRANSLATIONAL MEDICINE (2021)

Add to Collection

Article Immunology

Parasite Viability as a Superior Measure of Antimalarial Drug Activity in Humans

Maria Rebelo et al.

Summary: This study found that viable parasites in artemisinin-sensitive infections decreased to <0.1% of baseline within 8 hours after artesunate administration, while the total number of circulating parasites measured with quantitative polymerase chain reaction remained unchanged. In artemisinin-resistant infections over the same interval, viable parasites declined to 51.4% of baseline. These results suggest that the in vivo drug activity of artesunate is quicker than previously reported based on parasite clearance half-life.

JOURNAL OF INFECTIOUS DISEASES (2021)

Add to Collection

Review Biochemical Research Methods

Live and Let Dye: Visualizing the Cellular Compartments of the Malaria Parasite Plasmodium falciparum

Marleen Linzke et al.

CYTOMETRY PART A (2020)

Add to Collection

Review Parasitology

Malaria Parasite Clearance: What Are We Really Measuring?

David S. Khoury et al.

TRENDS IN PARASITOLOGY (2020)

Add to Collection

Article Infectious Diseases

Molecular epidemiology of resistance to antimalarial drugs in the Greater Mekong subregion: an observational study

Mallika Imwong et al.

LANCET INFECTIOUS DISEASES (2020)

Add to Collection

Article Chemistry, Medicinal

Identification of 2,4-Disubstituted Imidazopyridines as Hemozoin Formation Inhibitors with Fast-Killing Kinetics and In Vivo Efficacy in the Plasmodium falciparum NSG Mouse Model

Andre Horatscheck et al.

JOURNAL OF MEDICINAL CHEMISTRY (2020)

Add to Collection

Article Microbiology

Ivermectin Impairs the Development of Sexual and Asexual Stages of Plasmodium falciparum In Vitro

Lais Pessanha de Carvalho et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2019)

Add to Collection

Article Chemistry, Medicinal

Development of Chemical Entities Endowed with Potent Fast-Killing Properties against Plasmodium falciparum Malaria Parasites

Alexios N. Matralis et al.

JOURNAL OF MEDICINAL CHEMISTRY (2019)

Add to Collection

Article Infectious Diseases

Parasite reduction ratio one day after initiation of artemisinin-based combination therapies and its relationship with parasite clearance time in acutely malarious children

Kazeem Akano et al.

INFECTIOUS DISEASES OF POVERTY (2018)

Add to Collection

Article Multidisciplinary Sciences

A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance

Paul M. O'Neill et al.

NATURE COMMUNICATIONS (2017)

Add to Collection

Article Microbiology

Development of a Novel High-Density [3H] Hypoxanthine Scintillation Proximity Assay To Assess Plasmodium falciparum Growth

Cristina de Cozar et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2016)

Add to Collection

Article Multidisciplinary Sciences

Triaminopyrimidine is a fast-killing and long-acting antimalarial clinical candidate

Shahul P. Hameed et al.

NATURE COMMUNICATIONS (2015)

Add to Collection

Article Microbiology

Antimalarial Activity of the Myxobacterial Macrolide Chlorotonil A

Jana Held et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2014)

Add to Collection

Article Infectious Diseases

Fast in vitro methods to determine the speed of action and the stage-specificity of anti-malarials in Plasmodium falciparum

Claire Le Manach et al.

MALARIA JOURNAL (2013)

Add to Collection

Article Infectious Diseases

A novel live-dead staining methodology to study malaria parasite viability

Erica M. Pasini et al.

MALARIA JOURNAL (2013)

Add to Collection

Article Multidisciplinary Sciences

P. falciparum In Vitro Killing Rates Allow to Discriminate between Different Antimalarial Mode-of-Action

Laura M. Sanz et al.

PLOS ONE (2012)

Add to Collection

Article Biochemistry & Molecular Biology

An efficient fluorimetric method to measure the viability of intraerythrocytic Plasmodium falciparum

Astrid Evers et al.

BIOLOGICAL CHEMISTRY (2008)

Add to Collection

Article Microbiology

Simple histidine-rich protein 2 double-site sandwich enzyme-linked immunosorbent assay for use in malaria drug sensitivity testing

H Noedl et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2005)

Add to Collection

Article Microbiology

Histidine-rich protein II: a novel approach to malaria drug sensitivity testing

H Noedl et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2002)

Add to Collection

© Peeref 2019-2024. All rights reserved.