Astrocytes-derived exosomes pre-treated by berberine inhibit neuroinflammation after stroke via miR-182-5p/Rac1 pathway

Article Immunology

microRNAs Alterations of Myocardium and Brain Ischemia-Reperfusion Injury: Insight to Improve Infarction

Fatemeh Sabet Sarvestani et al.

Summary: Heart and cerebral infarctions, two important ischemic diseases, could be improved by regulating miRNAs after ischemia reperfusion injury.

IMMUNOLOGICAL INVESTIGATIONS (2022)

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Article Cell Biology

Sufentanil alleviates cerebral ischemia-reperfusion injury by inhibiting inflammation and protecting the blood-brain barrier in rats

Zhen Wang et al.

Summary: This study aimed to investigate the effect of sufentanil on cerebral ischemia-reperfusion injury (CIRI) in a rat model of ischemic stroke. The results showed that sufentanil alleviated infarct size, improved neurological function and brain edema, reduced the expression of inflammatory cytokines, protected the blood-brain barrier, and inhibited cell apoptosis.

EUROPEAN JOURNAL OF HISTOCHEMISTRY (2022)

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Article Neurosciences

Sevoflurane protects mice from cerebral ischaemic injury by regulating microRNA-203-3p/HDAC4/Bcl-2 axis

Jie Song et al.

Summary: This study demonstrates the neuroprotective effects of Sevoflurane in cerebral ischaemic injury. miR-203-3p enhances the protective effects of Sevo through up-regulation of Bcl-2 and down-regulation of HDAC4.

EUROPEAN JOURNAL OF NEUROSCIENCE (2022)

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Review Medicine, Research & Experimental

Dodging blood brain barrier with nano warriors: Novel strategy against ischemic stroke

Suhel Parvez et al.

Summary: Ischemic stroke is a major cause of death and disability worldwide, but the only approved treatment, tissue plasminogen activator, has limitations. There is a need for novel therapeutic perspectives, and nanomedicine offers new approaches to improve the understanding and treatment of ischemic stroke.

THERANOSTICS (2022)

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Article Biochemistry & Molecular Biology

Novel mechanistic insight on the neuroprotective effect of berberine: The role of PPAR8 for antioxidant action

Jia-Wen Shou et al.

Summary: Cerebral ischemic stroke is a major cause of death and disability worldwide, and effective therapeutic interventions are urgently needed. This study demonstrates that berberine (BBR) can alleviate stroke by scavenging ROS and activating PPAR8, leading to the upregulation of NRF1/2 and NQO1.

FREE RADICAL BIOLOGY AND MEDICINE (2022)

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Article Neurosciences

Long Non-coding RNA RMST Worsens Ischemic Stroke via MicroRNA-221-3p/PIK3R1/TGF-beta Signaling Pathway

Jie Li et al.

Summary: This study investigated the role of long non-coding RNA RMST in ischemic stroke through the miR-221-3p/PIK3R1/TGF-beta axis in MCAO mice. The results showed that elevated RMST and PIK3R1, downregulated miR-221-3p, and activated TGF-beta pathway were associated with MCAO, and restoring miR-221-3p or depleting RMST improved neurological functions and pathological damage. Additionally, depleting PIK3R1 or restoring miR-221-3p could counteract the negative effects of RMST overexpression in MCAO mice.

MOLECULAR NEUROBIOLOGY (2022)

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Correction Biochemistry & Molecular Biology

Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions (vol 7, 215, 2022)

Chuan Qin et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

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Article Biochemistry & Molecular Biology

Activation of neuronal Ras-related C3 botulinum toxin substrate 1 (Rac1) improves post-stroke recovery and axonal plasticity in mice

Fan Bu et al.

Summary: The study showed that neuronal Rac1 plays a crucial role in improving functional recovery and axonal regeneration after stroke, by promoting the regeneration of neurofilament-L and myelin basic protein, and reducing the invasion of glial fibrillary acidic protein. This suggests that neuronal Rac1 could be a potential therapeutic target for the recovery stage of stroke.

JOURNAL OF NEUROCHEMISTRY (2021)

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Article Neurosciences

Astrocyte-derived exosomes carry microRNA-17-5p to protect neonatal rats from hypoxic-ischemic brain damage via inhibiting BNIP-2 expression

Lin Du et al.

Summary: This study aimed to investigate the protective effect and mechanism of astrocyte-derived exosomes on neonatal rats with hypoxic-ischemic brain damage. The results showed that exosomes carried miR-17-5p to negatively regulate BNIP-2 expression, reducing brain damage and improving cell viability.

NEUROTOXICOLOGY (2021)

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Review Immunology

Understanding the Connection Between Common Stroke Comorbidities, Their Associated Inflammation, and the Course of the Cerebral Ischemia/Reperfusion Cascade

Lukasz Przykaza

Summary: Common concomitant stroke risk factors such as hypertension, diabetes, and hyperlipidemia exacerbate inflammatory processes during cerebral ischemia/reperfusion, leading to dysfunction of neurovascular units. In-depth basic research on these factors is crucial for the success of future neuroprotection, vasculoprotection, and immunomodulation therapies in stroke.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Cell Biology

Berberine Improves Cognitive Impairment by Simultaneously Impacting Cerebral Blood Flow and β-Amyloid Accumulation in an APP/tau/PS1 Mouse Model of Alzheimer's Disease

Chenghui Ye et al.

Summary: The administration of berberine to 3xTg AD mice improved cognitive deficits, reduced amyloid beta accumulation, inhibited neuronal apoptosis, and promoted the formation of microvessels in the brain, leading to enhanced cerebral blood flow recovery. Berberine showed neuroprotective effects and is a potential candidate for the multi-target prevention and treatment of Alzheimer's disease.

CELLS (2021)

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Article Biochemistry & Molecular Biology

Oral berberine improves brain dopa/dopamine levels to ameliorate Parkinson's disease by regulating gut microbiota

Yan Wang et al.

Summary: Oral berberine may enhance dopamine production in the brain by promoting the generation of l-dopa through gut bacteria. Combining berberine with bacteria shows better therapeutic effects than using bacteria alone.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

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Article Chemistry, Multidisciplinary