Journal
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
Volume 57, Issue -, Pages 246-259Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jmbbm.2015.12.015
Keywords
Tissue engineering; 3D printing; Esophagus; Melt-drawing; Microfiber; Tensile properties
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Tubular esophageal scaffolds with fiber diameter ranging from 13.9 +/- 1.7 mu m to 65.7 +/- 6.2 mu m were fabricated from the highly elastic poly(L-lactide-co-epsilon-caprolactone) (PLC) via a melt drawing, method. The morphology, crystallinity, thermal and mechanical properties of the PLC fibers were investigated. They were highly aligned and have a uniform diameter. PLC is found to be semicrystalline consisting of alpha- and beta- lactide (LA) crystals. The crystallinity increases up to 16.8% with increasing melt-drawing speeds due to strain-induced crystallization. Modulus and strength increases while ductility decreases with an increase in crystallinity of the PLC samples. Moisture will not degrade the overall tensile properties but affect its tangent modulus at the low strain. L929 cells are able to attach and proliferate on the scaffolds very well. The cells seeded on the scaffolds show normal morphology with >90% cell viability after 6 days of culture. These results demonstrate that the PLC fibrous scaffold has good potential for use in esophageal tissue engineering application. (C) 2015 Elsevier Ltd. All rights reserved.
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