Recurrences and bleeding during extended treatment of patients with venous thromboembolism: results of the international, prospective, observational WHITE study

Article Medicine, General & Internal

Unprovoked or provoked venous thromboembolism: not the prevalent criterion to decide on anticoagulation extension in clinical practice of various countries-the prospective, international, observational WHITE study

Gualtiero Palareti et al.

Summary: The study analyzed the treatment decisions for VTE patients in 7 countries, finding differences in management strategies. Most patients used DOACs, with an average maintenance anticoagulation duration of around 6 months. Approximately 20% stopped anticoagulation, 50% extended it, and over 25% received antithrombotic drugs instead of anticoagulants for extended treatment.

INTERNAL AND EMERGENCY MEDICINE (2022)

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Article Hematology

Influence of clinical presentation, site, and extent of venous thrombosis on decision about duration of anticoagulation: Data from the international, prospective, observational WHITE study

Gualtiero Palareti et al.

Summary: This study investigated the influence of clinical presentation, extent of venous thrombosis, and presence of residual vein obstruction on the decision about the duration of secondary prophylaxis after a first venous thromboembolism. The results showed that the decision varied among countries, with most patients with proximal or associated deep vein thrombosis continuing treatment, while patients with isolated distal thrombosis were more likely to stop treatment. Factors such as presence of concomitant diseases and risk of post-thrombotic syndrome also influenced the decision.

THROMBOSIS RESEARCH (2022)

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Article Hematology

Anticoagulation Duration After First Venous Thromboembolism: Real-Life Data From the International, Observational WHITE Study

Gualtiero Palareti et al.

Summary: This sub-analysis of the WHITE study aimed to assess the reasons for treatment decisions taken by doctors in different countries. It found significant variations in the decisions made for patients with provoked or unprovoked events, as well as for those with isolated distal deep vein thrombosis (IDDVT). The most prevalent reason for continuing anticoagulation was the high risk of recurrence, followed by the risk of bleeding and the presence of PTS signs, regardless of the nature and site of the index events.

CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS (2021)

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Article Cardiac & Cardiovascular Systems