Journal
INTERNAL MEDICINE
Volume 62, Issue 9, Pages 1279-1285Publisher
JAPAN SOC INTERNAL MEDICINE
DOI: 10.2169/internalmedicine.0434-22
Keywords
cyclophosphamide; enteritis; microscopic polyangiitis
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We report a case of severe enteritis after cyclophosphamide therapy, emphasizing the importance of prompt discontinuation of the drug and intensive management when gastrointestinal symptoms occur.
Severe enteritis is a rare side effect of cyclophosphamide (CPA) therapy, and only two cases have been reported to date. We herein report a 60-year-old man who developed severe enteritis after intravenous CPA administration for microscopic polyangiitis. He was successfully treated by discontinuation of CPA administration and long-term intensive supportive care. A diagnosis of CPA-associated enteritis was made based on the clinical course and imaging and pathological findings. This review of three cases of CPA-related enteritis, including our case, suggests that prompt CPA discontinuation and intensive systemic management are necessary when patients have gastrointestinal symptoms after CPA administration.
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