☆ 4.6 Editorial Material

B-cell follicles in tuberculous lung: Active defenders or modest bystanders?

IMMUNOLOGY (2023)

Related references

Note: Only part of the references are listed.

Article Biochemistry & Molecular Biology

Prolonged B-Lymphocyte-Mediated Immune and Inflammatory Responses to Tuberculosis Infection in the Lungs of TB-Resistant Mice

Irina Linge et al.

Summary: During tuberculosis infection, B-lymphocytes form B-cell follicles in the lungs near TB granulomata. B-cell depletion in infected primates alters T-lymphocyte responses and increases bacterial burdens. The role of B cells in late-stage TB remained unknown.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

Add to Collection

Article Microbiology

B cells promote granulomatous inflammation during chronic Mycobacterium tuberculosis infection in mice

Yong Chen et al.

Summary: In this study, it was shown that B cells can enhance lung inflammation and promote protective immune responses in chronic tuberculosis (TB) by restricting the expression of the anti-inflammatory molecule IL-10. However, this enhanced inflammation can also be detrimental to the host. In human TB, B cells may contribute to the development of severe pulmonic pathological responses. Understanding the role of B cells in TB is important for TB control.

PLOS PATHOGENS (2023)

Add to Collection

Article Multidisciplinary Sciences

Early alveolar macrophage response and IL-1R-dependent T cell priming determine transmissibility of Mycobacterium tuberculosis strains

Arianne Lovey et al.

Summary: In this study, the authors found that high transmission strains of Mycobacterium tuberculosis induce rapid migration of alveolar macrophages and early dissemination of bacteria to lymph nodes, resulting in greater transmissibility. In contrast, low transmission strains impede these processes and promote Th17 immunity, leading to neutrophilic inflammation and increased bacterial replication.

NATURE COMMUNICATIONS (2022)

Add to Collection

Article Immunology

Pleiotropic Effect of IL-6 Produced by B-Lymphocytes During Early Phases of Adaptive Immune Responses Against TB Infection

Irina Linge et al.

Summary: The study investigates the role of B cells in tuberculosis inflammation and the impact of IL-6 on TB susceptibility and immune responses. They found that B cells play a critical role in producing IL-6 at the initial stages of TB infection and that the deficiency of IL-6 in B cells is associated with alterations in B and T cell functioning.

FRONTIERS IN IMMUNOLOGY (2022)

Add to Collection

Article Cell Biology

Mycobacterium tuberculosis infection drives a type I IFN signature in lung lymphocytes

Sadia Akter et al.

Summary: Using single-cell RNA sequencing, this study reveals the enrichment of type I interferon signature and heat shock responses in lymphoid cell clusters and natural killer cells from Mycobacterium tuberculosis-infected mouse lungs. Ly6A is identified as a lymphoid cell activation marker, and its upregulation in activated lymphoid cells following infection is confirmed. Cross-analysis of type I interferon signature in human TB-infected peripheral blood samples further validates these findings.

CELL REPORTS (2022)

Add to Collection

Review Biochemistry & Molecular Biology

Immune cell interactions in tuberculosis

JoAnne L. Flynn et al.

Summary: Despite being identified as the cause of tuberculosis in 1882, Mycobacterium tuberculosis still remains poorly understood in terms of the protective immune response and effective vaccine development. Recent advancements in technology and experimental models have provided new insights into the heterogeneity of the bacteria and the host response. This review emphasizes the significance of a holistic approach in understanding the interaction between M. tuberculosis and the diverse host cells that contribute to the development of protective immunity.

CELL (2022)

Add to Collection

Review Immunology

B-Cells and Antibodies as Contributors to Effector Immune Responses in Tuberculosis

Willemijn F. Rijnink et al.

Summary: Recent studies have shown that B cells and antibodies play an important role in combating Mycobacterium tuberculosis. They exist in different functional subsets and may serve as potential biomarkers.

FRONTIERS IN IMMUNOLOGY (2021)

Add to Collection

Article Multidisciplinary Sciences

Elevation in the counts of IL-35-producing B cells infiltrating into lung tissue in mycobacterial infection is associated with the downregulation of Th1/Th17 and upregulation of Foxp3+Treg

Chen Chen et al.

SCIENTIFIC REPORTS (2020)

Add to Collection

Review Immunology

Host Cell Targets of Released Lipid and Secreted Protein Effectors of Mycobacterium tuberculosis

Jacques Augenstreich et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2020)

Add to Collection

Review Immunology

B lymphocytes in anti-mycobacterial immune responses: Pathogenesis or protection?

Alexander V. Dyatlov et al.

TUBERCULOSIS (2019)

Add to Collection

Article Critical Care Medicine

B Cells Producing Type I IFN Modulate Macrophage Polarization in Tuberculosis

Alan Benard et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2018)

Add to Collection

Article Respiratory System

The multifaceted roles of the matrikine Pro-Gly-Pro in pulmonary health and disease

Dhiren F. Patel et al.

EUROPEAN RESPIRATORY REVIEW (2018)

Add to Collection

Article Immunology

B-lymphocytes forming follicle-like structures in the lung tissue of tuberculosis-infected mice: Dynamics, phenotypes and functional activity

Irina Linge et al.

TUBERCULOSIS (2017)

Add to Collection

Review Immunology

Immunometabolism within the tuberculosis granuloma: amino acids, hypoxia, and cellular respiration

Joseph E. Qualls et al.

SEMINARS IN IMMUNOPATHOLOGY (2016)

Add to Collection

Review Immunology

The role of B cells and humoral immunity in Mycobacterium tuberculosis infection

John Chan et al.

SEMINARS IN IMMUNOLOGY (2014)

Add to Collection

Review Immunology

Follicular dendritic cells: dynamic antigen libraries

Balthasar A. Heesters et al.

NATURE REVIEWS IMMUNOLOGY (2014)

Add to Collection

Article Pathology

Activated B Cells in the Granulomas of Nonhuman Primates Infected with Mycobacterium tuberculosis

Jia Yao Phuah et al.

AMERICAN JOURNAL OF PATHOLOGY (2012)

Add to Collection

Review Immunology

Neutrophils in tuberculosis: friend or foe?

David M. Lowe et al.

TRENDS IN IMMUNOLOGY (2012)

Add to Collection

Article Multidisciplinary Sciences

B Cell Response Is Required for Granuloma Formation in the Early Infection of Schistosoma japonicum

Fang Ji et al.

PLOS ONE (2008)

Add to Collection

Article Multidisciplinary Sciences

ESAT-6-specific CD4 T cell responses to aerosol Mycobacterium tuberculosis infection are initiated in the mediastinal lymph nodes

William W. Reiley et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Add to Collection

Article Medicine, Research & Experimental

Inducible bronchus-associated lymphoid tissue (iBALT) in patients with pulmonary complications of rheumatoid arthritis

Javier Rangel-Moreno et al.

JOURNAL OF CLINICAL INVESTIGATION (2006)

Add to Collection

Article Immunology

Interleukin 12p40 is required for dendritic cell migration and T cell priming after Mycobacterium tuberculosis infection

Shabaana A. Khader et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2006)

Add to Collection

Article Immunology

Mycobacterial dissemination and cellular responses after 1-lobe restricted tuberculosis infection of genetically susceptible and resistant mice

VV Mischenko et al.

JOURNAL OF INFECTIOUS DISEASES (2004)

Add to Collection

Article Oncology

Human tuberculous granulomas induce peripheral lymphoid follicle-like structures to orchestrate local host defence in the lung

T Ulrichs et al.

JOURNAL OF PATHOLOGY (2004)

Add to Collection

Review Cell Biology

Bronchus-associated lymphoid tissue (BALT) is not present in the normal adult lung but in different diseases

T Tschernig et al.

PATHOBIOLOGY (2000)

Add to Collection

© Peeref 2019-2024. All rights reserved.