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Senescent T cells: Beneficial and detrimental roles

IMMUNOLOGICAL REVIEWS (2023)

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The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells

Alessio Lanna et al.

NATURE IMMUNOLOGY (2014)

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Article Microbiology

Engagement of NKG2D on Bystander Memory CD8 T Cells Promotes Increased Immunopathology following Leishmania major Infection

Erika J. Crosby et al.

PLOS PATHOGENS (2014)

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Review Immunology

Know thyself: NK-cel innibitory receptors prompt self-tolerance, education, and viral control

William T. Nash et al.

FRONTIERS IN IMMUNOLOGY (2014)

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Review Immunology

Interactions between HLA-G and HLA-E in physiological and pathological conditions

Fabio Morandi et al.

FRONTIERS IN IMMUNOLOGY (2014)

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Review Cell Biology

The impact of ageing on natural killer cell function and potential consequences for health in older adults

Jon Hazeldine et al.

AGEING RESEARCH REVIEWS (2013)

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Review Immunology

Memory CD4 T Cell-Mediated Immunity against Influenza A Virus: More than a Little Helpful

K. Kai McKinstry et al.

ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS (2013)

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Article Immunology

p53-dependent chemokine production by senescent tumor cells supports NKG2D-dependent tumor elimination by natural killer cells

Alexandre Iannello et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2013)

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Article Dermatology

CD8+ Granzyme B+-Mediated Tissue Injury vs. CD4+IFNγ+-Mediated Parasite Killing in Human Cutaneous Leishmaniasis

Claire da Silva Santos et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2013)

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Article Biochemistry & Molecular Biology

Molecular mechanisms involved in HIV-1-Tat mediated inhibition of telomerase activity in human CD4+ T lymphocytes

Alessandro Comandini et al.

MOLECULAR IMMUNOLOGY (2013)

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Article Multidisciplinary Sciences

Restoration of CMV-Specific-CD4 T Cells with ART Occurs Early and Is Greater in Those with More Advanced Immunodeficiency

Denise C. Hsu et al.

PLOS ONE (2013)

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Article Microbiology

Cytotoxic T Cells Mediate Pathology and Metastasis in Cutaneous Leishmaniasis

Fernanda O. Novais et al.

PLOS PATHOGENS (2013)

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Review Immunology

The Janus head of T cell aging - autoimmunity and immunodeficiency

Joerg J. Goronzy et al.

FRONTIERS IN IMMUNOLOGY (2013)

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Review Oncology

Role of non-classical MHC class I molecules in cancer immunosuppression

Grazyna Kochan et al.

ONCOIMMUNOLOGY (2013)

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Review Oncology

Immune surveillance of senescent cells-biological significance in cancer- and non-cancer pathologies

Lisa Hoenicke et al.

CARCINOGENESIS (2012)

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Review Immunology

Properties of end-stage human T cells defined by CD45RA re-expression

Sian M. Henson et al.

CURRENT OPINION IN IMMUNOLOGY (2012)

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Article Immunology

CX3CR1 drives cytotoxic CD4+CD28- T cells into the brain of multiple sclerosis patients

Bieke Broux et al.

JOURNAL OF AUTOIMMUNITY (2012)

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Article Virology

Multifunctional CD4 Cells Expressing Gamma Interferon and Perforin Mediate Protection against Lethal Influenza Virus Infection

Deborah M. Brown et al.

JOURNAL OF VIROLOGY (2012)

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Article Parasitology

The effect of age on the frequency of adverse reactions caused by antimony in the treatment of American tegumentary leishmaniasis in Governador Valadares, State of Minas Gerais, Brazil

Doracy Silva Diniz et al.

REVISTA DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL (2012)

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Review Cell Biology

Activating and inhibitory receptors of natural killer cells

Hollie J. Pegram et al.

IMMUNOLOGY AND CELL BIOLOGY (2011)

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Article Immunology

Reversible Senescence in Human CD4+CD45RA+CD27- Memory T Cells

Diletta Di Mitri et al.

JOURNAL OF IMMUNOLOGY (2011)

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Article Multidisciplinary Sciences

Senescence surveillance of pre-malignant hepatocytes limits liver cancer development

Tae-Won Kang et al.

NATURE (2011)

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Article Multidisciplinary Sciences

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

Darren J. Baker et al.

NATURE (2011)

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Article Immunology

Are senescence and exhaustion intertwined or unrelated processes that compromise immunity?

Arne N. Akbar et al.

NATURE REVIEWS IMMUNOLOGY (2011)

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Article Public, Environmental & Occupational Health

Cytomegalovirus Infection and the Risk of Mortality and Frailty in Older Women: A Prospective Observational Cohort Study

George C. Wang et al.

AMERICAN JOURNAL OF EPIDEMIOLOGY (2010)

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Review Pathology

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

Jean -Philippe Coppe et al.

ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2010)

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Article Immunology

Repetitive Antigen Stimulation Induces Stepwise Transcriptome Diversification but Preserves a Core Signature of Memory CD8+ T Cell Differentiation

Thomas C. Wirth et al.

IMMUNITY (2010)

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Article Immunology

Naive tumor-specific CD4+ T cells differentiated in vivo eradicate established melanoma

Ying Xie et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2010)

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Article Immunology

Human Cytomegalovirus Induces Systemic Immune Activation Characterized by a Type 1 Cytokine Signature

Pablo J. van de Berg et al.

JOURNAL OF INFECTIOUS DISEASES (2010)

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Article Otorhinolaryngology

Risk factors associated with dizziness during treatment of mucosal leishmaniasis with meglumine antimoniate: 16-year retrospective study of cases from Rio de Janeiro, Brazil

M. H. Araujo-Melo et al.

JOURNAL OF LARYNGOLOGY AND OTOLOGY (2010)

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Article Public, Environmental & Occupational Health

Association of Treatment of American Cutaneous Leishmaniasis Prior to Ulcer Development with High Rate of Failure in Northeastern Brazil

Alon Unger et al.

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE (2009)

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Article Hematology

ATM-ATR-dependent up-regulation of DNAM-1 and NKG2D ligands on multiple myeloma cells by therapeutic agents results in enhanced NK-cell susceptibility and is associated with a senescent phenotype

Alessandra Soriani et al.

BLOOD (2009)

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Article Cell Biology

IL-2 and antigen dose differentially regulate perforin- and FasL-mediated cytolytic activity in antigen specific CD4+ T cells

Deborah M. Brown et al.

CELLULAR IMMUNOLOGY (2009)

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Heterogeneity of CD4+ memory T cells: Functional modules for tailored immunity

Federica Sallusto et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2009)

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Recruitment of CD8+ T cells expressing granzyme A is associated with lesion progression in human cutaneous leishmaniasis

D. R. Faria et al.

PARASITE IMMUNOLOGY (2009)

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Review Virology

Cytomegalovirus and human immunosenescence

Graham Pawelec et al.

REVIEWS IN MEDICAL VIROLOGY (2009)

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Senescence-messaging secretome: SMS-ing cellular stress

Thomas Kuilman et al.

NATURE REVIEWS CANCER (2009)

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Article Biochemistry & Molecular Biology

Senescence of activated stellate cells limits liver fibrosis

Valery Krizhanovsky et al.

CELL (2008)

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Review Biochemical Research Methods

Phenotype and Function of Human T Lymphocyte Subsets: Consensus and Issues

Victor Appay et al.

CYTOMETRY PART A (2008)

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Immunosenescent colitogenic CD4+ T cells convert to regulatory cells and suppress colitis

Teruji Totsuka et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2008)

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Review Biochemistry & Molecular Biology

Function and regulation in MAPK signaling pathways:: Lessons learned from the yeast Saccharomyces cerevisiae

Raymond E. Chen et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2007)

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Article Immunology

The loss of telomerase activity in highly differentiated CD8+CD28-CD27- T cells is associated with decreased Akt (Ser473) phosphorylation

Fiona J. Plunkett et al.

JOURNAL OF IMMUNOLOGY (2007)

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Article Infectious Diseases

Resistance of Leishmania (Leishmania) amazonensis and Leishmania (Viannia) braziliensis to nitric oxide correlates with disease severity in Tegumentary Leishmaniasis

Angela Giudice et al.

BMC INFECTIOUS DISEASES (2007)

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Article Multidisciplinary Sciences

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

Wen Xue et al.

NATURE (2007)

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Review Immunology

MAPK phosphatases - regulating the immune response

Yusen Liu et al.

NATURE REVIEWS IMMUNOLOGY (2007)

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Expression and function of NKG2D in CD4+ T cells specific for human cytomegalovirus

Andrea Saez-Borderias et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2006)

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Article Hematology

Strong selection of virus-specific cytotoxic CD4+ T-cell clones during primary human cytomegalovirus infection

Ester M. M. van Leeuwen et al.

BLOOD (2006)

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Stimulation history dictates memory CD8 T cell phenotype: Implications for prime-boost vaccination

David Masopust et al.

JOURNAL OF IMMUNOLOGY (2006)

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Article Immunology

CD4 T cell-mediated protection from lethal influenza: Perforin and antibody-mediated mechanisms a one-two punch

Deborah M. Brown et al.

JOURNAL OF IMMUNOLOGY (2006)

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Article Immunology

Cytomegalovirus-specific CD4+ T cells in healthy carriers are continuously driven to replicative exhaustion

JM Fletcher et al.

JOURNAL OF IMMUNOLOGY (2005)

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Article Oncology

CD8 T cells expressing NK associated receptors are increased in melanoma patients and display an effector phenotype

JG Casado et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2005)

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Review Immunology

Memory T cell homeostasis and senescence during aging

AN Akbar et al.

CURRENT OPINION IN IMMUNOLOGY (2005)

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Article Multidisciplinary Sciences

The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor

S Gasser et al.

NATURE (2005)

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Article Cell Biology

The impact of telomere erosion on memory CD8+ T cells in patients with X-linked lymphoproliferative syndrome

FJ Plunkett et al.

MECHANISMS OF AGEING AND DEVELOPMENT (2005)

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Review Immunology

Age-related changes in lymphocyte development and function

PJ Linton et al.

NATURE IMMUNOLOGY (2004)

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Emergence of a CD4+CD28- granzyme B+, cytomegalovirus-specific T cell subset after recovery of primary cytomegalovirus infection

EMM van Leeuwen et al.

JOURNAL OF IMMUNOLOGY (2004)

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Article Immunology

Herpesvirus-specific CD8 T cell immunity in old age: Cytomegalovirus impairs the response to a coresident EBV infection

N Khan et al.

JOURNAL OF IMMUNOLOGY (2004)

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Article Cardiac & Cardiovascular Systems

CD4+CD28-T lymphocytes contribute to early atherosclerotic damage in rheumatoid arthritis patients

R Gerli et al.

CIRCULATION (2004)

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NF-kB regulates expression of the MHC class I-related chain A gene-in activated T lymphocytes

LL Molinero et al.

JOURNAL OF IMMUNOLOGY (2004)

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Article Immunology

CD8+ T-cell immunity to cytomegalovirus

P Moss et al.

HUMAN IMMUNOLOGY (2004)

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Review Geriatrics & Gerontology

Immunosenescence, autoimmunity, and rheumatoid arthritis

CM Weyand et al.

EXPERIMENTAL GERONTOLOGY (2003)

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Article Multidisciplinary Sciences

Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases

GL Johnson et al.

SCIENCE (2002)

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Up-regulation of Th1-type responses in mucosal leishmaniasis patients

O Bacellar et al.

INFECTION AND IMMUNITY (2002)

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Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability

AV Budanov et al.

ONCOGENE (2002)

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Characterization of CD4+ CTLs ex vivo

V Appay et al.

JOURNAL OF IMMUNOLOGY (2002)

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Article Biochemistry & Molecular Biology

Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections

V Appay et al.

NATURE MEDICINE (2002)

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Article Medicine, General & Internal

Telomerase activation, cellular immortalization and cancer

WC Hahn et al.

ANNALS OF MEDICINE (2001)

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Article Immunology

Costimulation of CD8αβ T cells by NKG2D via engagement by MIC induced on virus-infected cells

V Groh et al.

NATURE IMMUNOLOGY (2001)

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Article Multidisciplinary Sciences

Mammalian MAP kinase signalling cascades

LF Chang et al.

NATURE (2001)

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Article Oncology

Accumulation of short telomeres in human fibroblasts prior to replicative senescence

UM Martens et al.

EXPERIMENTAL CELL RESEARCH (2000)

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