Journal
IMMUNOLOGICAL REVIEWS
Volume 316, Issue 1, Pages 8-22Publisher
WILEY
DOI: 10.1111/imr.13218
Keywords
CD8 T cell; immune memory; tissue-resident memory T cell; TRM heterogeneity
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Cytotoxic CD8(+) T cells recognize and eliminate infected or cancerous cells. Tissue-resident memory T cells (T-RM) reside in peripheral tissues and are able to acclimate to the tissue environment for long-term survival.
Cytotoxic CD8(+) T cells recognize and eliminate infected or cancerous cells. A subset of CD8(+) memory T cells called tissue-resident memory T cells (T-RM) resides in peripheral tissues, monitors the periphery for pathogen invasion, and offers a rapid and potent first line of defense at potential sites of re-infection. T-RM cells are found in almost all tissues and are transcriptionally and epigenetically distinct from circulating memory populations, which shows their ability to acclimate to the tissue environment to allow for long-term survival. Recent work and the broader availability of single-cell profiling have highlighted T-RM heterogeneity among different tissues, as well as identified specialized subsets within individual tissues, that are time and infection dependent. T-RM cell phenotypic and transcriptional heterogeneity has implications for understanding T-RM function and longevity. This review aims to summarize and discuss the latest findings on CD8(+) T-RM heterogeneity using single-cell molecular profiling and explore the potential implications for immune protection and the design of immune therapies.
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