X marks the shot against malaria

The development of a transmission-blocking vaccine (TBV) against malaria is hampered by poor understand-ing of functional antibody responses. In this issue of Immunity, Fabra-Garcia et al., Ivanochko et al., and Tang et al. isolate human monoclonal antibodies against the two most promising TBV candidates, Pfs48/45 and Pfs230, and map the epitopes responsible for potent transmission-reducing activity.

Automated summary

In this study, researchers isolated human monoclonal antibodies against two potential transmission-blocking vaccine candidates for malaria, Pfs48/45 and Pfs230, and identified the epitopes responsible for their transmission-reducing activity.