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Regulation of systemic metabolism by tissue-resident immune cell circuits

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Western Diet and the Immune System: An Inflammatory Connection

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Contribution of Macrophage Efferocytosis to Liver Homeostasis and Disease

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A circadian clock is essential for homeostasis of group 3 innate lymphoid cells in the gut

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Circadian rhythm-dependent and circadian rhythm-independent impacts of the molecular clock on type 3 innate lymphoid cells

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A common transcriptomic program acquired in the thymus defines tissue residency of MAIT and NKT subsets

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Commensal and Pathogenic Bacteria Indirectly Induce IL-22 but Not IFNγ Production From Human Colonic ILC3s via Multiple Mechanisms

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The STAT3-IL-10-IL-6 Pathway Is a Novel Regulator of Macrophage Efferocytosis and Phenotypic Conversion in Sterile Liver Injury

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IL-10 Signaling Remodels Adipose Chromatin Architecture to Limit Thermogenesis and Energy Expenditure

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Alterations in Intestinal Microbiota Lead to Production of Interleukin 17 by Intrahepatic γδ T-Cell Receptor-Positive Cells and Pathogenesis of Cholestatic Liver Disease

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Oxysterol Sensing through the Receptor GPR183 Promotes the Lymphoid-Tissue-Inducing Function of Innate Lymphoid Cells and Colonic Inflammation

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gamma delta T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis

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Anti-microbial Functions of Group 3 Innate Lymphoid Cells in Gut-Associated Lymphoid Tissues Are Regulated by G-Protein-Coupled Receptor 183

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Antibodies Set Boundaries Limiting Microbial Metabolite Penetration and the Resultant Mammalian Host Response

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Innate and adaptive lymphocytes sequentially shape the gut microbiota and lipid metabolism

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Regulatory T Cells Promote Macrophage Efferocytosis during Inflammation Resolution

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A Liver Capsular Network of Monocyte-Derived Macrophages Restricts Hepatic Dissemination of Intraperitoneal Bacteria by Neutrophil Recruitment

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Adipose-derived circulating miRNAs regulate gene expression in other tissues

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The intestinal microbiota regulates body composition through NFIL3 and the circadian clock

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Microglial Inflammatory Signaling Orchestrates the Hypothalamic Immune Response to Dietary Excess and Mediates Obesity Susceptibility

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Interleukin 17 is a chief orchestrator of immunity

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IL-25 or IL-17E Protects against High-Fat Diet-Induced Hepatic Steatosis in Mice Dependent upon IL-13 Activation of STAT6

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CD47 Deficiency Protects Mice From Diet-induced Obesity and Improves Whole Body Glucose Tolerance and Insulin Sensitivity

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Interleukin-1β mediates macrophage-induced impairment of insulin signaling in human primary adipocytes

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Purinergic signaling via P2Y receptors up-mediates IL-6 production by liver macrophages/Kupffer cells

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Interleukin-22 alleviates metabolic disorders and restores mucosal immunity in diabetes

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Innate lymphoid cells integrate stromal and immunological signals to enhance antibody production by splenic marginal zone B cells

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Activated group 3 innate lymphoid cells promote T-cell-mediated immune responses

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Microbiota-Dependent Crosstalk Between Macrophages and ILC3 Promotes Intestinal Homeostasis

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Adaptation of Innate Lymphoid Cells to a Micronutrient Deficiency Promotes Type 2 Barrier Immunity

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Microglia Dictate the Impact of Saturated Fat Consumption on Hypothalamic Inflammation and Neuronal Function

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Tissue-resident natural killer (NK) cells are cell lineages distinct from thymic and conventional splenic NK cells

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IL-17 inhibits adipogenesis in part via C/EBPα, PPARγ and Kruppel-like factors

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IL-25 Prevents and Cures Fulminant Hepatitis in Mice Through a Myeloid-Derived Suppressor Cell-Dependent Mechanism

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Interleukin-33-Dependent Innate Lymphoid Cells Mediate Hepatic Fibrosis

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Liver-resident NK cells confer adaptive immunity in skin-contact inflammation

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Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages

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IL-17A Plays a Critical Role in the Pathogenesis of Liver Fibrosis through Hepatic Stellate Cell Activation

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Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria

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P2X7 receptor-mediated purinergic signaling promotes liver injury in acetaminophen hepatotoxicity in mice

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AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2012)

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NK cells from HCV-infected patients effectively induce apoptosis of activated primary human hepatic stellate cells in a TRAIL-, FasL- and NKG2D-dependent manner

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Interleukin-17 exacerbates hepatic steatosis and inflammation in non-alcoholic fatty liver disease

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Lack of Interleukin-1 Receptor I (IL-1RI) Protects Mice From High-Fat Diet Induced Adipose Tissue Inflammation Coincident With Improved Glucose Homeostasis

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OX40 and CD30 signals in CD4+ T-cell effector and memory function: a distinct role for lymphoid tissue inducer cells in maintaining CD4+ T-cell memory but not effector function

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Aging Is Associated with an Increase in T Cells and Inflammatory Macrophages in Visceral Adipose Tissue

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Eosinophils Sustain Adipose Alternatively Activated Macrophages Associated with Glucose Homeostasis

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Adipose tissue macrophages in insulin-resistant subjects are associated with collagen VI and fibrosis and demonstrate alternative activation

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AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2010)

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Interleukin-17-Producing CD4(+) T Cells Increase with Severity of Liver Damage in Patients with Chronic Hepatitis B

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Involvement of Th17 and Th1 Effector Responses in Patients with Hepatitis B

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A bone-protective role for IL-17 receptor signaling in ovariectomy-induced bone loss

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Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

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Ablation of CD11c-Positive Cells Normalizes Insulin Sensitivity in Obese Insulin Resistant Animals

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Neurotransmitters activate T-cells and elicit crucial functions via neurotransmitter receptors

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IL-23 and Th17 cytokines in intestinal homeostasis

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The control of hepatic glycogen metabolism in an in vitro model of sepsis

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Macrophage-specific PPARγ controls alternative activation and improves insulin resistance

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Angiogenic role of LYVE-1-positive macrophages in adipose tissue

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Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract

AM Owyang et al.

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Role of hepatic STAT3 in brain-insulin action on hepatic glucose production

H Inoue et al.

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Natural killer cells ameliorate liver fibrosis by killing activated stellate cells in NKG2D-dependent and tumor necrosis factor-related apoptosis-inducing ligand-dependent manners

S Radaeva et al.

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CCR2 modulates inflammatory and metabolic effects of high-fat feeding

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Cytokine-induced IL-10-secreting CD8 T cells represent a phenotypically distinct suppressor T-cell lineage

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Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo

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Negative regulation of liver regeneration by innate immunity (natural killer cells/interferon-γ)

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Reduced hepatic glycogen stores in patients with liver cirrhosis

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ICAM-1 triggers liver regeneration through leukocyte recruitment and Kupffer cell-dependent release of TNF-α/IL-6 in mice

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Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

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Chronic exposure to interleukin-6 causes hepatic insulin resistance in mice

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Interleukin-6 induces cellular insulin resistance in hepatocytes

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The liver as a site of T-cell apoptosis: graveyard, or krilling field?

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