An orphan no more Nur77 senses cytosolic LPS

Article Immunology

The orphan receptor Nur77 binds cytoplasmic LPS to activate the non-canonical NLRP3 inflammasome

Fangrui Zhu et al.

Summary: By biochemical screening, we identified the nuclear orphan receptor Nur77 as an intracellular LPS-binding protein, which binds mitochondrial DNA and LPS to activate the non-canonical NLRP3 inflammasome, contributing to the sensing of intracellular LPS and immune response.

IMMUNITY (2023)

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Review Immunology

NLRP3 inflammasome in cancer and metabolic diseases

Bhesh Raj Sharma et al.

Summary: The NLRP3 inflammasome plays diverse roles in cancer and metabolic diseases, being involved in the release of inflammatory cytokines and inflammatory cell death upon activation. While inflammatory cytokines contribute to chronic inflammation and disease pathogenesis, fine tuning NLRP3 activity is crucial for maintaining cellular health.

NATURE IMMUNOLOGY (2021)

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Article Immunology

Evolution-inspired redesign of the LPS receptor caspase-4 into an interleukin-1β-converting enzyme

Pascal Devant et al.

Summary: Innate immune signaling pathways involve multiple proteins that promote inflammation, with the complexity being a prerequisite for pathway design. Through studying caspases that regulate inflammation, it was found that different caspases can complement each other, condensing a multistep pathway into a single protein.

SCIENCE IMMUNOLOGY (2021)

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Article Immunology