An orphan no more Nur77 senses cytosolic LPS

Cytosolic LPS activates the NLRP3 inflammasome via a gasdermin D (GSDMD)-dependent mechanism. In this issue of Immunity, Zhu et al.(1) provide insight into the events linking these two steps, identifying the orphan nuclear receptor Nur77 as a mediator of NLRP3 activation that senses LPS and GSDMD-dependent accumulation of cytosolic mtDNA.

Automated summary

In this study, the researchers found that cytosolic LPS activates the NLRP3 inflammasome through a mechanism involving gasdermin D (GSDMD). They also identified the orphan nuclear receptor Nur77 as a mediator of NLRP3 activation, which senses LPS and GSDMD-dependent accumulation of cytosolic mtDNA.