Journal
IMMUNITY
Volume 56, Issue 4, Pages 742-744Publisher
CELL PRESS
DOI: 10.1016/j.immuni.2023.03.012
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In this study, the researchers found that cytosolic LPS activates the NLRP3 inflammasome through a mechanism involving gasdermin D (GSDMD). They also identified the orphan nuclear receptor Nur77 as a mediator of NLRP3 activation, which senses LPS and GSDMD-dependent accumulation of cytosolic mtDNA.
Cytosolic LPS activates the NLRP3 inflammasome via a gasdermin D (GSDMD)-dependent mechanism. In this issue of Immunity, Zhu et al.(1) provide insight into the events linking these two steps, identifying the orphan nuclear receptor Nur77 as a mediator of NLRP3 activation that senses LPS and GSDMD-dependent accumulation of cytosolic mtDNA.
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