Journal
ADVANCED MATERIALS
Volume 27, Issue 42, Pages 6637-+Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201503093
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Funding
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Science, ICT & Future Planning [2014R1A2A1A11049526, 2010-0029206, NRF-2012R1A4A1028835]
- Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea [HI14C2202]
- Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) - Ministry of Health & Welfare, Republic of Korea [HI15C0001]
- KIST Institutional Program [2E25000]
- Korea Health Promotion Institute [HR15C0009010015] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Council of Science & Technology (NST), Republic of Korea [2E25000] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2010-0029206, 2012R1A4A1028835] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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New protein nanocages are designed bearing two functional proteins, gamma-carboxyglutamic acid of protein C (PC-Gla) and thrombin receptor agonist peptide (TRAP), and have an anti-septic response. These nanoparticles reduce sepsis-induced organ injury and septic mortality in vivo. Noting that there are currently no medications for severe sepsis, these results show that novel nanoparticles can be used to treat sepsis.
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