Minimally Invasive Implant Type Electromagnetic Biosensor for Continuous Glucose Monitoring In Vivo Evaluation

Objective: Continuous glucose monitoring system (CGMS) is growing popular and preferred by diabetes over conventional methods of self-blood glucose monitoring (SBGM) systems. However, currently available commercial CGMS in the market is useful for few days to few months. This paper presents a durable, highly sensitive and minimally invasive implant type electromagnetic sensor for continuous glucose monitoring that is capable of tracking minute changes in blood glucose level (BGL). Methods: The proposed sensor utilizes strong oscillating nearfield to detect minute changes in dielectric permittivity of interstitial fluid (ISF) and blood due to changes in BGL. A biocompatible packaging material is used to cover the sensor. It helps in minimizing foreign body reactions (FBR) and improves stability of the sensor. Results: The performance of the proposed sensor was evaluated on live rodent models (C57BL/6J mouse and Sprague Dawley rat) through intravenous glucose and insulin tolerance tests. Biocompatible polyolefin was used as the sensor packaging material, and the effect of packaging thickness on the sensitivity of sensor was examined in in-vivo test. Proposed sensor could track real-time BGL change measured with a commercial blood glucose meter. High linear correlation (R-2 > 0.9) with measured BGL was observed during in vivo experiments. Conclusion: The experimental results demonstrate that the proposed sensor is suitable for long term CGMS applications with a high accuracy. Significance: Present work offers a new perspective towards development of long term CGM system using electromagnetic based implant sensor. The in vivo evaluation of the sensor shows excellent tracking of BGL changes.

Automated summary

This paper presents a durable and minimally invasive implant type electromagnetic sensor for continuous glucose monitoring. The proposed sensor is capable of tracking minute changes in blood glucose level, and it has been successfully tested on live rodent models. The results demonstrate that the sensor is suitable for long term CGMS applications with high accuracy.