☆ 4.7 Article

Single-Cell Transcriptome Analysis of Peripheral Neutrophils From Patients With Idiopathic Pulmonary Arterial Hypertension

HYPERTENSION (2023)

Related references

Note: Only part of the references are listed.

Editorial Material Biochemistry & Molecular Biology

Structural insights into the activation of chemokine receptor CXCR2

Kaiwen Liu et al.

Summary: The study reveals the binding modes between CXCL8 and CXCR2, CXCR2 and G protein, as well as the detailed binding pattern of the allosteric antagonist 00767013. Further analysis also uncovers the unique shallow-pocket activation mechanism of CXCR2 and suggests a potential role of cholesterol in allosteric modulation in chemokine receptors.

FEBS JOURNAL (2022)

Add to Collection

Review Cardiac & Cardiovascular Systems

New Mutations and Pathogenesis of Pulmonary Hypertension: Progress and Puzzles in Disease Pathogenesis

Micheala A. Aldred et al.

Summary: Pulmonary arterial hypertension (PAH) is a complex disease characterized by alterations in the pulmonary circulation, leading to right heart failure and death. Mutations in the BMPRII gene account for a majority of PAH cases, but rare mutations in other genes have also been identified. Understanding these new PAH-related genes can provide insights into the pathogenesis and potential therapeutic targets for this incurable disorder.

CIRCULATION RESEARCH (2022)

Add to Collection

Article Critical Care Medicine

Endogenous Retroviral Elements Generate Pathologic Neutrophils in Pulmonary Arterial Hypertension

Shalina Taylor et al.

Summary: This study reveals the functional abnormalities of neutrophils and their extracellular vesicles in patients with pulmonary arterial hypertension, and links these abnormalities to proteomic and transcriptomic mechanisms.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2022)

Add to Collection

Article Immunology

Mechanistic insight into premature atherosclerosis and cardiovascular complications in systemic lupus erythematosus

Yudong Liu et al.

Summary: Systemic lupus erythematosus (SLE) is strongly associated with cardiovascular disease (CVD), and the interaction between immune dysregulation and traditional CVD risk factors plays a significant role in the development of premature atherosclerosis and CVD in SLE. Abnormal systemic inflammation in SLE can lead to lipid profile and function irregularities, further promoting a pro-atherosclerotic environment. Profound immune dysregulation, including excessive type I interferon burden, aberrant macrophage, platelet and complements activation, etc., contributes to accelerated CVD in SLE.

JOURNAL OF AUTOIMMUNITY (2022)

Add to Collection

Article Immunology

Single-Cell Analysis Reveals the Range of Transcriptional States of Circulating Human Neutrophils

Gustaf Wigerblad et al.

Summary: Neutrophils, previously thought to be homogeneous and transcriptionally inactive, have been found to be transcriptionally heterogeneous and can be classified into four clusters. This discovery, made possible by modifications to the data analysis pipeline, has potential implications for the characterization of neutrophils in health and disease.

JOURNAL OF IMMUNOLOGY (2022)

Add to Collection

Article Dermatology

Neutrophils Enhance Cutaneous Vascular Dilation and Permeability to Aggravate Psoriasis by Releasing Matrix Metallopeptidase 9

Jiaoling Chen et al.

Summary: Neutrophil infiltration and papillary vessel dilation are characteristic features of the initiation phase of psoriatic lesions. Our study found that neutrophils activate cutaneous vascular endothelial cells, leading to vascular remodeling, vasodilation, and enhanced vascular permeability both in vivo and in vitro. Furthermore, MMP-9 secreted by psoriatic neutrophils activates vascular endothelial cells and enhances CD4(+) T-cell transmigration, facilitating the development of psoriatic lesions.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2021)

Add to Collection

Editorial Material Critical Care Medicine

Matrix Metalloproteinase-8 in Pulmonary Hypertension: The Sheep in the Wolf's Skin?

Elena A. Goncharova et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2021)

Add to Collection

Article Multidisciplinary Sciences

Type I interferon activation and endothelial dysfunction in caveolin-1 insufficiency-associated pulmonary arterial hypertension

Salina Gairhe et al.

Summary: Interferonopathies, IFN-alpha/beta therapy, and CAV1 loss-of-function are associated with PAH. CAV1-silenced PAECs exhibit proliferative and hypermigratory behavior, with activation of STAT and PI3K/AKT pathways, leading to an IFN-biased inflammatory signature. Cav1(-/-) mice with pulmonary hypertension show STAT1 and AKT activation, increased CXCL10 levels, and PAH patients with CAV1 mutations display similar phenotypic features.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Add to Collection

Article Multidisciplinary Sciences

The neutrotime transcriptional signature defines a single continuum of neutrophils across biological compartments

Ricardo Grieshaber-Bouyer et al.

Summary: Neutrophils exhibit a single developmental spectrum, ranging from immature pre-neutrophils in the bone marrow to mature neutrophils in the blood and spleen. Inflammation affects neutrophil transcriptional states, leading to varying transcriptional activities at different sites.

NATURE COMMUNICATIONS (2021)

Add to Collection

Article Cell Biology

Cell landscape atlas for patients with chronic thromboembolic pulmonary hypertension after pulmonary endarterectomy constructed using single-cell RNA sequencing

Ran Miao et al.

Summary: This study aimed to construct an atlas of the cell landscape and comprehensively characterize the cellular repertoire of pulmonary endarterectomized tissues in patients with CTEPH. Through single-cell RNA sequencing, the study identified 17 cell clusters classified into eight cell types, providing valuable insights into disease pathophysiology. Features of fibroblast/smooth muscle cells, endothelial cells, immune cells, and other cell types were significantly enriched with various functions, while CRISPLD2+ cell showed no significant enrichment, highlighting potential therapeutic targets.

AGING-US (2021)

Add to Collection

Article Cardiac & Cardiovascular Systems

Metalloproteinases and their inhibitors are associated with pulmonary arterial stiffness and ventricular function in pediatric pulmonary hypertension

Michal Schafer et al.

Summary: The disturbed balance between matrix metalloproteinases (MMPs) and tissue inhibitors (TIMPs) is recognized as a pathophysiological component of pulmonary arterial hypertension (PAH). This study found that levels of MMPs and TIMPs in children with PAH were associated with standard cardiac MRI hemodynamic indices and markers of pulmonary arterial stiffness, suggesting their potential as prognostic indicators in PAH.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2021)

Add to Collection

Article Critical Care Medicine

Severe Pulmonary Arterial Hypertension Is Characterized by Increased Neutrophil Elastase and Relative Elafin Deficiency

Andrew J. Sweatt et al.

Summary: The study revealed that PAH patients have elevated levels of NE and decreased levels of elafin, which are associated with more severe clinical disease and outcomes. NE levels can serve as a specific biomarker for the treatment of elafin.

CHEST (2021)

Add to Collection

Article Critical Care Medicine

Whole-Blood RNA Profiles Associated with Pulmonary Arterial Hypertension and Clinical Outcome

Christopher J. Rhodes et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2020)

Add to Collection

Article Immunology

Single-cell transcriptome profiling reveals neutrophil heterogeneity in homeostasis and infection

Xuemei Xie et al.

NATURE IMMUNOLOGY (2020)

Add to Collection

Review Cell Biology

Perivascular Inflammation in Pulmonary Arterial Hypertension

Yijie Hu et al.

CELLS (2020)

Add to Collection

Article Hematology

Adventitial Cell Atlas of wt (Wild Type) and ApoE (Apolipoprotein E)-Deficient Mice Defined by Single-Cell RNA Sequencing

Wenduo Gu et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2019)

Add to Collection

Article Respiratory System

Pathology and pathobiology of pulmonary hypertension: state of the art and research perspectives

Marc Humbert et al.

EUROPEAN RESPIRATORY JOURNAL (2019)

Add to Collection

Article Biochemical Research Methods

fastp: an ultra-fast all-in-one FASTQ preprocessor

Shifu Chen et al.

BIOINFORMATICS (2018)

Add to Collection

Review Microbiology

ISG15 in antiviral immunity and beyond

Yi-Chieh Perng et al.

NATURE REVIEWS MICROBIOLOGY (2018)

Add to Collection

Article Multidisciplinary Sciences

Single-cell reconstruction of the early maternal-fetal interface in humans

Roser Vento-Tormo et al.

NATURE (2018)

Add to Collection

Review Cardiac & Cardiovascular Systems

Inflammation and autoimmunity in pulmonary hypertension: is there a role for endothelial adhesion molecules? (2017 Grover Conference Series)

Wolfgang M. Kuebler et al.

PULMONARY CIRCULATION (2018)

Add to Collection

Review Medicine, General & Internal

The Role of Neutrophils and Neutrophil Elastase in Pulmonary Arterial Hypertension

Shalina Taylor et al.

FRONTIERS IN MEDICINE (2018)

Add to Collection

Article Biochemistry & Molecular Biology

UMI-tools: modeling sequencing errors in Unique Molecular Identifiers to improve quantification accuracy

Tom Smith et al.

GENOME RESEARCH (2017)

Add to Collection

Article Biochemistry & Molecular Biology

Extracellular ISG15 Signals Cytokine Secretion through the LFA-1 Integrin Receptor

Caleb D. Swaim et al.

MOLECULAR CELL (2017)

Add to Collection

Review Immunology

Mitochondrial DNA in innate immune responses and inflammatory pathology

A. Phillip West et al.

NATURE REVIEWS IMMUNOLOGY (2017)

Add to Collection

Review Respiratory System

Interferon-induced pulmonary hypertension: an update

Laurent Savale et al.

CURRENT OPINION IN PULMONARY MEDICINE (2016)

Add to Collection

Article Cardiac & Cardiovascular Systems

Biomarkers of tissue remodeling predict survival in patients with pulmonary hypertension

Svenja L. Tiede et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2016)

Add to Collection

Article Respiratory System

Electronic cigarette exposure triggers neutrophil inflammatory responses

Andrew Higham et al.

RESPIRATORY RESEARCH (2016)

Add to Collection

Article Critical Care Medicine

Elafin Reverses Pulmonary Hypertension via Caveolin-1-Dependent Bone Morphogenetic Protein Signaling

Nils P. Nickel et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2015)

Add to Collection

Article Respiratory System

2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension

Nazzareno Galie et al.

EUROPEAN RESPIRATORY JOURNAL (2015)

Add to Collection

Article Medicine, Research & Experimental

Prognostic value of neutrophil-to-lymphocyte ratio in pulmonary arterial hypertension

Ebru Ozpelit et al.

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH (2015)

Add to Collection

Review Cardiac & Cardiovascular Systems

Inflammation and Immunity in the Pathogenesis of Pulmonary Arterial Hypertension

Marlene Rabinovitch et al.

CIRCULATION RESEARCH (2014)

Add to Collection

Article Respiratory System

Pulmonary arterial hypertension in patients treated with interferon

Laurent Savale et al.

EUROPEAN RESPIRATORY JOURNAL (2014)

Add to Collection

Article Biochemical Research Methods

STAR: ultrafast universal RNA-seq aligner

Alexander Dobin et al.

BIOINFORMATICS (2013)

Add to Collection

Article Respiratory System

Matrix metalloproteinases and their inhibitors in pulmonary hypertension

Prakash Chelladurai et al.

EUROPEAN RESPIRATORY JOURNAL (2012)

Add to Collection

Article Hematology

Bone morphogenetic protein receptor II regulates pulmonary artery endothelial cell barrier function

Victoria J. Burton et al.

BLOOD (2011)

Add to Collection

Article Cardiac & Cardiovascular Systems

Elevated Levels of Inflammatory Cytokines Predict Survival in Idiopathic and Familial Pulmonary Arterial Hypertension

Elaine Soon et al.

CIRCULATION (2010)

Add to Collection

Article Dermatology

The Pathogenesis of Photoaging: The Role of Neutrophils and Neutrophil-Derived Enzymes

Feiko Rijken et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS (2009)

Add to Collection

Article Biochemical Research Methods

Three-colour fluorescence immunohistochemistry reveals the diversity of cells staining for macrophage markers in murine spleen and liver

Catherine M. Lloyd et al.

JOURNAL OF IMMUNOLOGICAL METHODS (2008)

Add to Collection

Article Respiratory System

Peripheral blood B lymphocytes derived from patients with idiopathic pulmonary arterial hypertension express a different RNA pattern compared with healthy controls: a cross sectional study

Silvia Ulrich et al.

RESPIRATORY RESEARCH (2008)

Add to Collection

Article Pharmacology & Pharmacy

A novel flow cytometric assay of human whole blood neutrophil and monocyte CD11b levels: Upregulation by chemokines is related to receptor expression, comparison with neutrophil shape change, and effects of a chemokine receptor (CXCR2) antagonist

Grant C. Nicholson et al.

PULMONARY PHARMACOLOGY & THERAPEUTICS (2007)

Add to Collection

Article Pathology

Hypoxia-induced pulmonary vascular remodeling requires recruitment of circulating mesenchymal precursors of a monocyte/macrophage lineage

MG Frid et al.

AMERICAN JOURNAL OF PATHOLOGY (2006)

Add to Collection

Article Pharmacology & Pharmacy

Interleukin-17 and airway remodelling

A Linden

PULMONARY PHARMACOLOGY & THERAPEUTICS (2006)

Add to Collection

Article Hematology

The transcriptional program of terminal granulocytic differentiation

K Theilgaard-Mönch et al.

BLOOD (2005)

Add to Collection

Article Cardiac & Cardiovascular Systems

Cellular and molecular pathobiology of pulmonary arterial hypertension

M Humbert et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2004)

Add to Collection

Article Hematology

Increased neutrophil mediator release in patients with pulmonary hypertension - suppression by inhaled iloprost

F Rose et al.

THROMBOSIS AND HAEMOSTASIS (2003)

Add to Collection

Review Oncology

Neutrophil gelatinase B and chemokines in leukocytosis and stem cell mobilization

S Starckx et al.

LEUKEMIA & LYMPHOMA (2002)

Add to Collection

© Peeref 2019-2024. All rights reserved.