Opening the black box: why do euploid blastocysts fail to implant? A systematic review and meta-analysis

Article Obstetrics & Gynecology

The concordance rates of an initial trophectoderm biopsy with the rest of the embryo using PGTseq, a targeted next-generation sequencing platform for preimplantation genetic testing-aneuploidy

Julia Kim et al.

Summary: This study aims to determine the frequency at which the results of a single trophectoderm biopsy tested by PGTseq reflect the biology of the rest of the embryo.

FERTILITY AND STERILITY (2022)

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Review Cell Biology

Maternal selection of human embryos in early gestation: Insights from recurrent miscarriage

Jan J. Brosens et al.

Summary: Compared to other mammals, human pregnancy is unique in its involvement of chromosomally diverse embryos and the cyclical breakdown and regeneration of the uterine mucosa. Understanding the mechanisms behind miscarriage can provide insights into the maternal selection of embryos during early gestation.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2022)

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Article Obstetrics & Gynecology

Relationship between paternal factors and embryonic aneuploidy of paternal origin

Marissa L. Bonus et al.

Summary: This study investigated the relationship between paternal factors and embryonic aneuploidy of paternal origin using PGT-A in 453 in vitro fertilization cycles. The results showed that there was no association between paternal age, BMI, or semen analysis parameters and paternal aneuploidy.

FERTILITY AND STERILITY (2022)

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Article Obstetrics & Gynecology

How slow is too slow? A comprehensive portrait of Day 7 blastocysts and their clinical value standardized through artificial intelligence

Danilo Cimadomo et al.

Summary: The study demonstrates that Day 7 blastocysts have a slightly lower euploidy rate and live birth rate compared to faster-growing embryos with better morphology, but still hold clinical value.

HUMAN REPRODUCTION (2022)

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Article Obstetrics & Gynecology

Sperm selection with hyaluronic acid improved live birth outcomes among older couples and was connected to sperm DNA quality, potentially affecting all treatment outcomes

Robert West et al.

Summary: What effects did treatment using hyaluronic acid (HA) binding/selection prior to ICSI have on clinical outcomes in the Hyaluronic Acid Binding sperm Selection (HABSelect) clinical trial? Older women randomized to the trial's experimental arm (selection of sperm bound to immobilized (solid-state) HA) had the same live birth rates as younger women, most likely a result of better avoidance of sperm with damaged DNA. Recent randomized controlled trials (RCTs) investigating the efficacy of HA-based sperm selection prior to ICSI, including HABSelect, have consistently reported reductions in the numbers of miscarriages among couples randomized to the intervention, suggesting a pathological sperm-mediated factor mitigated by prior HA-binding/selection. The mechanism of that protection is unknown.

HUMAN REPRODUCTION (2022)

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Review Obstetrics & Gynecology

Morphological and morphokinetic associations with aneuploidy: a systematic review and meta-analysis

Thomas Bamford et al.

Summary: This systematic review and meta-analysis explores the associations between ploidy status and morphokinetic or morphological features on a time lapse system. The study identifies useful morphokinetic variables for future model development and emphasizes the need for robust testing of these models given the heterogeneity in results. The results suggest potential in predicting ploidy status using morphokinetic features, but further research is needed to draw reliable conclusions.

HUMAN REPRODUCTION UPDATE (2022)

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Letter Medicine, General & Internal

Trends and Outcomes for Preimplantation Genetic Testing in the United States, 2014-2018

Heather S. Hipp et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2022)

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Review Genetics & Heredity

Oocyte aging: looking beyond chromosome segregation errors

Daniela Bebbere et al.

Summary: The age-associated decline in female fertility is mainly due to a decrease in oocyte quality. This decline is influenced by various maternal and environmental factors. An increase in the rate of meiotic errors is the main cause of the decline in oocyte developmental competence. However, as women age, abnormalities in the ooplasm, such as altered metabolism, organelle dysfunction, and aberrant gene regulation, gradually weaken oocyte quality. Accumulation of maternal macromolecules during folliculogenesis is crucial for oocyte competence, as transcription is not required for oocyte maturation, fertilization, and early embryo development. Factors such as assisted reproduction technologies (ARTs) or environmental changes can interfere with the crucial remodeling of oocyte epigenetics during oogenesis, and the effects may be amplified by reproductive aging. Since the molecular mechanisms of maternal aging on human oocyte function are not well understood, studies in animal models are necessary to deepen our understanding and have translational implications for human ARTs.

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS (2022)

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Article Obstetrics & Gynecology

A microenvironment of high lactate and low pH created by the blastocyst promotes endometrial receptivity and implantation

Kathryn H. Gurner et al.

Summary: This study suggests that lactate may play an important role in maternal-fetal dialogue, promoting endometrial receptivity and implantation. Further investigation of the role of lactate in infertile or compromised endometrium could potentially improve pregnancy success.

REPRODUCTIVE BIOMEDICINE ONLINE (2022)

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Article Cell Biology

The effects of the day of trophectoderm biopsy and blastocyst grade on the clinical and neonatal outcomes of preimplantation genetic testing-frozen embryo transfer cycles

Linjun Chen et al.

Summary: This study analyzed the impact of TE biopsy day and blastocyst grade on clinical and neonatal outcomes. The results showed that day 5 TE biopsy had higher rates of implantation and live births compared to day 6 TE biopsy. The miscarriage rate was lower for day 5 TE biopsy, but the difference was not statistically significant. Higher quality blastocysts achieved better implantation and live birth rates. Among good quality blastocysts, there was no significant difference between day 5 and day 6 TE biopsy rates. However, for fair and poor quality blastocysts, day 5 TE biopsy had significantly higher rates than day 6 TE biopsy. Neither blastocyst grade nor TE biopsy day significantly affected the miscarriage rate. Neonatal outcomes such as newborn sex, gestational age, preterm birth, birth weight, and low birth weight did not significantly differ between day 5 and day 6 TE biopsies. Both blastocyst grade and TE biopsy day should be considered together in preimplantation genetic testing-frozen embryo transfer.

ZYGOTE (2022)

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Review Nutrition & Dietetics

Personalized Nutrition in the Management of Female Infertility: New Insights on Chronic Low-Grade Inflammation

Gemma Fabozzi et al.

Summary: There is a mutual association between nutrition and female fertility, and personalized nutrition might be more effective for infertile patients.

NUTRIENTS (2022)

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Review Physiology

The Quiet Embryo Hypothesis: 20 years on

Henry J. Leese et al.

Summary: This article revisits the hypothesis proposed in 2002 that the successful development of oocytes and preimplantation mammalian embryos is associated with quiet metabolism. It introduces the concept of a Goldilocks zone, an optimal range of metabolic activity within which embryos with maximum developmental potential are located.

FRONTIERS IN PHYSIOLOGY (2022)

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Article Obstetrics & Gynecology

Human blastocyst spontaneous collapse is associated with worse morphological quality and higher degeneration and aneuploidy rates: a comprehensive analysis standardized through artificial intelligence

Danilo Cimadomo et al.

Summary: Approximately 50% of human blastocysts spontaneously collapse, especially those that are non-viable, morphologically poor, and aneuploid. Blastocyst collapse is associated with lower competence, and the worse the blastocyst quality, the more frequent and prolonged the collapse.

HUMAN REPRODUCTION (2022)

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Article Obstetrics & Gynecology

Different actors for the same play: the impact of the embryologist performing the embryo transfer

Federico Cirillo et al.

Summary: This study investigates the impact of embryologist and physician on the outcome of embryo transfer, finding that both factors significantly affect the ongoing pregnancy rate (OPR), with physicians having a slightly greater contribution. The experience of embryologists does not have a significant association with the outcome.

REPRODUCTIVE BIOMEDICINE ONLINE (2022)

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Review Genetics & Heredity

On the reproductive capabilities of aneuploid human preimplantation embryos

Antonio Capalbo et al.

Summary: The use of aneuploidy testing in IVF cycles is increasing, with almost half of cycles in the US undergoing PGT-A. Evidence shows that embryos diagnosed with uniform whole-chromosome aneuploidy rarely result in live births, while embryos with low-level mosaicism for whole chromosomes have reproductive capabilities similar to euploid embryos. Differentiating between uniform and mosaic aneuploidy is crucial in clinical and research settings for proper management of aneuploid embryos.

AMERICAN JOURNAL OF HUMAN GENETICS (2022)

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Article Obstetrics & Gynecology

Use of the endometrial receptivity array to guide personalized embryo transfer after a failed transfer attempt was associated with a lower cumulative and per transfer live birth rate during donor and autologous cycles

Mauro Cozzolino et al.

Summary: This study aimed to investigate whether personalized embryo transfer (pET) guided by endometrial receptivity array (ERA) test improves reproductive outcomes for fresh embryo transfers (fsETs) or frozen embryo transfers (FETs) during autologous and donor cycles. The results showed that live birth rate and cumulative live birth rate were higher in FET and fsET groups than in pET groups, even with euploid transfers. Logistic regression analysis indicated that patients receiving pET had poorer outcomes than those undergoing FET and fsET in both autologous and donor cycles. Implantation, pregnancy, and clinical pregnancy rates were also lower in patients undergoing pET.

FERTILITY AND STERILITY (2022)

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Article Obstetrics & Gynecology

Endometriosis does not impact live-birth rates in frozen embryo transfers of euploid blastocysts

Lauren A. Bishop et al.

Summary: In this retrospective cohort study, no differences in pregnancy outcomes were observed between patients with endometriosis and the control groups. Aneuploidy rates were similar between endometriosis patients and male factor infertility patients, indicating that endometriosis may not primarily affect in vitro fertilization outcomes through oocyte quality or the endometrium.

FERTILITY AND STERILITY (2021)

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Article Obstetrics & Gynecology

Can embryo morphokinetic parameters predict euploid pregnancy loss?

Dana B. McQueen et al.

Summary: The study found no significant differences in morphokinetic parameters between embryos resulting in euploid pregnancy loss and those resulting in live birth, indicating that euploid pregnancy loss may be multifactorial.

FERTILITY AND STERILITY (2021)

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Article Obstetrics & Gynecology

A multicenter, prospective, blinded, nonselection study evaluating the predictive value of an aneuploid diagnosis using a targeted next-generation sequencing-based preimplantation genetic testing for aneuploidy assay and impact of biopsy

Ashley W. Tiegs et al.

Summary: The study aimed to determine the predictive value of PGT-A testing in forecasting the failure of successful delivery, finding high accuracy in predicting delivery failure with aneuploid results. Additionally, trophectoderm biopsy did not have a detectable adverse impact on sustained implantation.

FERTILITY AND STERILITY (2021)

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Article Obstetrics & Gynecology

Rate of true recurrent implantation failure is low: results of three successive frozen euploid single embryo transfers

Paul Pirtea et al.

Summary: The study retrospectively analyzed data from 4,429 women and found that the true recurrent implantation failure rate is low. For patients capable of producing euploid blastocysts, transferring three embryos can still achieve a high clinical pregnancy rate.

FERTILITY AND STERILITY (2021)

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Article Genetics & Heredity

Mosaic human preimplantation embryos and their developmental potential in a prospective, non-selection clinical trial

Antonio Capalbo et al.

Summary: Research has shown that low-medium mosaicism in the trophectoderm mostly arises after TE and ICM differentiation, and such embryos have equivalent developmental potential as fully euploid ones.

AMERICAN JOURNAL OF HUMAN GENETICS (2021)

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Article Obstetrics & Gynecology

Endometriosis shows no impact on the euploid blastocyst rate per cohort of inseminated metaphase-II oocytes: A case-control study

Alberto Vaiarelli et al.

Summary: The study results suggest that endometriosis may not impair oocyte developmental and reproductive competence, and it does not have a significant impact on euploidy rates.

EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY (2021)

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Article Obstetrics & Gynecology

Routine endometrial receptivity array in first embryo transfer cycles does not improve live birth rate

Carrie Riestenberg et al.

Summary: The study aimed to compare the live birth rate between patients undergoing ERA/pET and standard timing FET in first autologous single euploid programmed embryo transfer cycles. The findings do not support the routine use of ERA in an unselected patient population undergoing their first autologous single euploid programmed embryo transfer.

FERTILITY AND STERILITY (2021)

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Article Obstetrics & Gynecology

Impact of low serum progesterone levels on the day of embryo transfer on pregnancy outcome: a prospective cohort study in artificial cycles with vaginal progesterone

Elena Labarta et al.

Summary: In artificial endometrial preparation cycles, serum progesterone levels below 8.8 ng/ml on the day of embryo transfer significantly reduce the chances of ongoing pregnancy, regardless of the origin of the oocytes. Monitoring progesterone levels and adjusting doses accordingly is recommended for optimizing outcomes in assisted reproductive technology cycles.

HUMAN REPRODUCTION (2021)

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Article Genetics & Heredity

Does blastocyst mitochondrial DNA content affect miscarriage rate in patients undergoing single euploid frozen embryo transfer?

Ahmed El-Damen et al.

Summary: The study found no significant correlation between blastocyst mitochondrial DNA content and miscarriage rate in patients undergoing single euploid frozen embryo transfer.

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS (2021)

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Article Genetics & Heredity

Endometrial compaction does not predict live birth rate in single euploid frozen embryo transfer cycles

Carrie Riestenberg et al.

Summary: The study found that in medicated single euploid frozen embryo transfer cycles, the majority did not show endometrial compaction and endometrial compaction was not associated with live birth rates or spontaneous abortion rates.

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS (2021)

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Article Obstetrics & Gynecology

Diminished ovarian reserve is associated with reduced euploid rates via preimplantation genetic testing for aneuploidy independently from age: evidence for concomitant reduction in oocyte quality with quantity

Eleni Greenwood Jaswa et al.

Summary: Women with diminished ovarian reserve have lower euploid blastocyst rates, but no significant difference in live birth rates after euploid single-embryo transfer, regardless of age.

FERTILITY AND STERILITY (2021)

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Article Obstetrics & Gynecology

The Appraisal of Body Content (ABC) trial: Increased male or female adiposity does not significantly impact in vitro fertilization laboratory or clinical outcomes

Julia Kim et al.

Summary: Maternal obesity was found to have some impact on IVF outcomes, with increased risk of very low birth weight infants, but most embryology and pregnancy outcomes were equivalent to normal weight patients. Paternal obesity did not appear to affect IVF, pregnancy, or delivery outcomes.

FERTILITY AND STERILITY (2021)

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Editorial Material Obstetrics & Gynecology

Embryo-endometrium crosstalk: a new understanding from in vitro model

Tianren Wang et al.

FERTILITY AND STERILITY (2021)

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Article Obstetrics & Gynecology

Individualised luteal phase support in artificially prepared frozen embryo transfer cycles based on serum progesterone levels: a prospective cohort study

Manuel Alvarez et al.

Summary: This study investigated whether individualized luteal phase support based on serum progesterone levels the day before embryo transfer can improve pregnancy outcomes for patients with low progesterone. The results showed that adding daily subcutaneous progesterone injections for patients with low progesterone levels prior to embryo transfer can lead to similar reproductive outcomes as those with adequate progesterone levels.

HUMAN REPRODUCTION (2021)

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Article Obstetrics & Gynecology

Perturbations of morphogenesis at the compaction stage affect blastocyst implantation and live birth rates

Giovanni Coticchio et al.

Summary: The study showed that the exclusion and extrusion of cells during blastocyst formation have a significant impact on the embryo development and clinical outcomes, especially with negative effects on pregnancy and live birth rates.

HUMAN REPRODUCTION (2021)

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Article Obstetrics & Gynecology

Leave the past behind: women' reproductive history shows no association with blastocysts' euploidy and limited association with live birth rates after euploid embryo transfers

Danilo Cimadomo et al.

Summary: The study found no association between patients' reproductive history and the mean euploidy rates per biopsied blastocysts, but reported a lower live birth rate after euploid blastocyst transfer in women with a history of repeated implantation failure. The clinical outcomes of the first single vitrified-warmed euploid blastocyst transfer showed an implantation rate of 51%, a miscarriage rate of 14%, and a live birth rate of 44%.

HUMAN REPRODUCTION (2021)

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Article Medicine, General & Internal

Live Birth with or without Preimplantation Genetic Testing for Aneuploidy

Junhao Yan et al.

Summary: In this randomized, controlled trial comparing PGT-A with conventional IVF in women with three or more good-quality blastocysts, it was found that the cumulative live-birth rate with conventional IVF was noninferior to that with PGT-A.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Genetics & Heredity

Oocyte competence is independent of the ovulation trigger adopted: a large observational study in a setting that entails vitrified-warmed single euploid blastocyst transfer

Danilo Cimadomo et al.

Summary: The study found that using GnRH-a or u-hCG ovulation triggers in vitrified-warmed euploid blastocyst transfer did not significantly affect oocyte maturity and implantation rates. However, there was an impact on the overall live birth rate due to factors such as patient age and number of inseminated oocytes.

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS (2021)

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Article Genetics & Heredity

Trophectoderm biopsy protocols may impact the rate of mosaic blastocysts in cycles with pre-implantation genetic testing for aneuploidy

Shun Xiong et al.

Summary: Different biopsy protocols may impact the rate of mosaic blastocysts, with ZP opening combined with TE biopsy potentially increasing the incidence of mosaic blastocysts.

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS (2021)

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Article Obstetrics & Gynecology

Inter-centre reliability in embryo grading across several IVF clinics is limited: implications for embryo selection

Danilo Cimadomo et al.

REPRODUCTIVE BIOMEDICINE ONLINE (2021)

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Article Obstetrics & Gynecology

Comparison of single euploid blastocyst transfer cycle outcome derived from embryos with normal or abnormal cleavage patterns

Irem Yarali Ozbek et al.

Summary: The study aimed to assess abnormal cleavage in biopsied blastocysts, compare euploidy rates of blastocysts with abnormal and normal cleavage, and analyze single euploid blastocyst transfer (SEBT) outcomes. Results showed blastocysts with abnormal cleavage had higher euploidy rates compared to those with normal cleavage, but lower live birth rates after SEBT. Abnormal cleavage pattern was the only independent predictor of live birth rate, suggesting blastocysts with abnormal cleavage should have lower priority for transfer.

REPRODUCTIVE BIOMEDICINE ONLINE (2021)

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Article Obstetrics & Gynecology

Blastulation rates of sibling oocytes in two IVF culture media: an evidence-based workflow to implement newly commercialized products

Gemma Fabozzi et al.

Summary: A study on sibling oocytes from women aged 42 years or younger undergoing ICSI cycles with ejaculated spermatozoa compared blastulation rates of a novel Geri-medium and a continuous single culture medium (CSCM), showing similar rates but differences in blastocyst morphology and developmental timings. Euploidy and ongoing implantation rates were similar between the two media, suggesting further research on the observed differences is needed.

REPRODUCTIVE BIOMEDICINE ONLINE (2021)

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Article Obstetrics & Gynecology

Multiple cryopreservation-warming cycles, coupled with blastocyst biopsy, negatively affect IVF outcomes

Ashley Aluko et al.

Summary: The study demonstrates that multiple cryopreservation-warming cycles, coupled with blastocyst biopsy, have a negative impact on IVF outcomes, including reduced live birth and clinical pregnancy rates. However, there was no significant difference in miscarriage rates between the groups. Therefore, caution should be exercised when considering further embryonic micromanipulation after cryopreservation.

REPRODUCTIVE BIOMEDICINE ONLINE (2021)

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Article Obstetrics & Gynecology

Deep learning neural network analysis of human blastocyst expansion from time-lapse image files

Thomas T. F. Huang et al.

Summary: The study investigates the use of AI for selecting single blastocysts for transfer based on their cellular area and expansion rate. Results show that the AI platform can accurately classify blastocyst phenotypes and analyze expansion rates, providing potential benefits over traditional methods.

REPRODUCTIVE BIOMEDICINE ONLINE (2021)

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Article Obstetrics & Gynecology

Which factors affect the likelihood of miscarriage after single euploid blastocyst transfer?

Fazilet K Boynukalin et al.

REPRODUCTIVE BIOMEDICINE ONLINE (2021)

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Article Obstetrics & Gynecology

Next-Generation Sequencing (NGS)-Based Preimplantation Genetic Testing for Aneuploidy (PGT-A) of Trophectoderm Biopsy for Recurrent Implantation Failure (RIF) Patients: a Retrospective Study

Jing Tong et al.

Summary: The study found that maternal age does not affect the implantation potential of euploid blastocysts, while embryo-related factors play a crucial role in RIF patients. The use of NGS-based PGT-A biopsy can significantly improve the clinical outcomes of advanced age RIF patients, serving as a valuable supplement to current RIF management.

REPRODUCTIVE SCIENCES (2021)

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Article Cell Biology

Prolonged interval time between blastocyst biopsy and vitrification compromised the outcomes in preimplantation genetic testing

Shun Xiong et al.

Summary: This study found that vitrification of blastocysts beyond 1 hour after biopsy significantly influences embryo survival and clinical outcomes in patients undergoing frozen embryo transfer, and is therefore not recommended.

ZYGOTE (2021)

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Article Endocrinology & Metabolism

The Morphology of Inner Cell Mass Is the Strongest Predictor of Live Birth After a Frozen-Thawed Single Embryo Transfer

Jihui Ai et al.

Summary: The blastocyst expansion stage, ICM grade, and TE grade are all associated with pregnancy outcomes. ICM grade is the strongest predictor of live birth. A blastocyst with stage 4-5, ICM grade A, and TE grade A/B should be given priority for single embryo transfer.

FRONTIERS IN ENDOCRINOLOGY (2021)

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Article Biochemistry & Molecular Biology

Trophectoderm Mitochondrial DNA Content Associated with Embryo Quality and Day-5 Euploid Blastocyst Transfer Outcomes

Jie Wang et al.

Summary: Mitochondrial DNA content may be a potential predictive biomarker for embryo implantation and reproductive potential, as studies have shown variations in mtDNA quantities between embryos of different quality. The findings suggest that mtDNA content could play a role in influencing implantation and live birth outcomes of transferred embryos, particularly for day-5 euploid blastocysts.

DNA AND CELL BIOLOGY (2021)

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Article Obstetrics & Gynecology

The use of propensity score matching to assess the benefit of the endometrial receptivity analysis in frozen embryo transfers

Keri Bergin et al.

Summary: The study found that there was no significant difference in live birth rates between patients who underwent endometrial receptivity analysis (ERA) and those who did not, regardless of prior number of FET cycles or receptivity status.

FERTILITY AND STERILITY (2021)

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Article Obstetrics & Gynecology

The true incidence of chromosomal mosaicism after preimplantation genetic testing is much lower than that indicated by trophectoderm biopsy

L. Wu et al.

Summary: The true incidence of chromosomal mosaicism is lower than previously thought, highlighting the need for further research to confirm these findings and address the challenges posed by false-positive and false-negative errors in NGS-based PGT.

HUMAN REPRODUCTION (2021)

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Article Endocrinology & Metabolism

Mitochondrial DNA Content May Not Be a Reliable Screening Biomarker for Live Birth After Single Euploid Blastocyst Transfer

Xuanyou Zhou et al.

Summary: The study found that there was no significant association between blastocyst mtDNA content and live birth rate or embryo implantation potential. Therefore, mtDNA content does not seem to be a potential biomarker for embryo transfer outcomes based on the existing testing tools. Embryos with elevated mtDNA content still have development potential for successful live birth.

FRONTIERS IN ENDOCRINOLOGY (2021)

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Article Genetics & Heredity

Elevated serum progesterone does not impact euploidy rates in PGT-A patients

Maria Luisa Pardinas et al.

Summary: This study investigated the impact of elevated serum progesterone on embryo quality in patients undergoing preimplantation genetic testing. The results showed that age was the only variable significantly associated with euploidy rate, while elevated serum progesterone did not affect the number of euploid or good-quality embryos. Further studies are needed to fully understand the effect of progesterone elevation on reproductive outcomes.

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS (2021)

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Article Obstetrics & Gynecology

Serum anti-Mullerian hormone levels are not associated with aneuploidy rates in human blastocysts

Angela Pipari et al.

Summary: The study found that while higher AMH levels were associated with a higher number of biopsied embryos, the rate of aneuploid embryos was relatively lower in the high AMH group. Additionally, there was no significant difference in the rate of aneuploid embryos across different ranges of AMH values. Overall, there was no significant correlation between AMH and embryo aneuploidy.

REPRODUCTIVE BIOMEDICINE ONLINE (2021)

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Article Obstetrics & Gynecology

Correlation between plasmatic progesterone, endometrial receptivity genetic assay and implantation rates in frozen-thawed transferred euploid embryos. A multivariate analysis

G. Barrenetxea et al.

Summary: This study aimed to explore the predictive value of different parameters in determining endometrial receptivity after single embryo transfer of frozen-thawed euploid blastocysts in assisted reproduction treatments. It was found that BMI and cumulative progesterone administered prior to the test are independent predictive factors of endometrial receptivity, while endometrial thickness and plasmatic progesterone levels were not correlated with endometrial receptivity.

EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY (2021)

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Article Obstetrics & Gynecology

Female obesity increases the risk of miscarriage of euploid embryos

Mauro Cozzolino et al.

Summary: The study found that obese women have a higher risk of miscarriage after euploid embryo transfer compared to women with normal weight, suggesting that factors other than chromosomal abnormalities may be responsible for this outcome.

FERTILITY AND STERILITY (2021)

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Editorial Material Obstetrics & Gynecology

Weighing in: the impact of obesity on euploid miscarriage rates

Elizabeth S. Ginsburg et al.

FERTILITY AND STERILITY (2021)

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Article Obstetrics & Gynecology

Length of estradiol exposure > 100 pg/ml in the follicular phase affects pregnancy outcomes in natural frozen embryo transfer cycles

Phillip A. Romanski et al.

Summary: The study found that an estradiol level exceeding 100pg/ml before ovulation and continuing to increase is associated with worse pregnancy and live birth outcomes. However, the total length of the follicular phase does not impact pregnancy and live birth outcomes.

HUMAN REPRODUCTION (2021)

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Article Obstetrics & Gynecology

Global transcriptomic changes occur in uterine fluid-derived extracellular vesicles during the endometrial window for embryo implantation

E. Giacomini et al.

Summary: The transcriptomic cargo of UF-EVs reflects the RNA profile of the endometrial tissue as well as changes between the non-receptive and the receptive phase, supporting its use for a novel endometrial receptivity test. These findings suggest that UF-EVs could serve as a reservoir for potential less-invasive collection of receptivity markers, advancing the field of reproductive medicine with real-time monitoring of endometrial status.

HUMAN REPRODUCTION (2021)

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Article Obstetrics & Gynecology

Plasticity of the human preimplantation embryo: developmental dogmas, variations on themes and self-correction

Giovanni Coticchio et al.

Summary: Recent evidence from time-lapse technology and preimplantation genetic testing highlights the remarkable plasticity of human embryos in vitro, challenging current embryological notions and suggesting the need for new rules governing preimplantation development.

HUMAN REPRODUCTION UPDATE (2021)

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Article Genetics & Heredity

Individual culture leads to decreased blastocyst formation but does not affect pregnancy outcomes in the setting of a single, vitrified-warmed euploid blastocyst transfer

Haley N. Glatthorn et al.

Summary: While individual culture may reduce the formation of usable blastocysts compared to group culture, there were no significant differences in pregnancy outcomes after the transfer of a single, vitrified-warmed euploid blastocyst.

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS (2021)

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Article Genetics & Heredity

Embryo quality, ploidy, and transfer outcomes in male versus female blastocysts

Christopher P. Moutos et al.

Summary: Male and female embryos have similar grade and quality, but female embryos are more likely to be aneuploid. Ongoing pregnancy rates do not differ by embryo sex. Day 5 embryos have more favorable transfer outcomes compared to day 6 embryos.

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS (2021)

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Article Genetics & Heredity

Live birth rate from euploid blastocysts is not associated with infertility etiology or oocyte source following frozen-thawed embryo transfer (FET): analysis of 4148 cycles reported to SART CORS

F. Meng et al.

Summary: After controlling for confounding variables, a euploid embryo derived from a donor or autologous oocyte results in similar live birth rates in women with different infertility diagnoses.

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS (2021)

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Article Obstetrics & Gynecology

Effect of Embryo Developmental Stage, Morphological Grading, and Ploidy Status on Live Birth Rate in Frozen Cycles of Single Blastocyst Transfer

Hui Ji et al.

Summary: The study found that in nonbiopsied frozen embryo transfer cycles, transferring D5 blastocysts and good-quality embryos resulted in higher live birth rates. While embryo developmental stage and morphological grade are useful predictors of live birth rate in nonbiopsied FET cycles, no association was found in euploid transfer cycles.

REPRODUCTIVE SCIENCES (2021)

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Article Endocrinology & Metabolism

Infertile patients with inflammatory bowel disease have comparable in vitro fertilization clinical outcomes to the general infertile population

Carlos Hernandez-Nieto et al.

GYNECOLOGICAL ENDOCRINOLOGY (2020)

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Review Obstetrics & Gynecology

Non-invasive preimplantation genetic testing (niPGT): the next revolution in reproductive genetics?

Megan Leaver et al.

HUMAN REPRODUCTION UPDATE (2020)

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Article Genetics & Heredity

Sperm DNA fragmentation on the day of fertilization is not associated with embryologic or clinical outcomes after IVF/ICSI

Katherine A. Green et al.

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS (2020)

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Article Obstetrics & Gynecology

Frozen-thawed embryo transfer: the potential importance of the corpus luteum in preventing obstetrical complications

Bhuchitra Singh et al.

FERTILITY AND STERILITY (2020)

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Article Obstetrics & Gynecology

Embryo's Natural Motion (enMotion): a paired randomized controlled trial evaluating a dynamic embryo culture system

Caroline R. Juneau et al.

FERTILITY AND STERILITY (2020)

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Article Obstetrics & Gynecology

The effect of ICSI-related procedural timings and operators on the outcome

Roberta Maggiulli et al.

HUMAN REPRODUCTION (2020)

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Article Obstetrics & Gynecology

Intracytoplasmic sperm injection is not superior to conventional IVF in couples with non-male factor infertility and preimplantation genetic testing for aneuploidies (PGT-A)

Neelke De Munck et al.

HUMAN REPRODUCTION (2020)

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Article Obstetrics & Gynecology

The human factor: does the operator performing the embryo transfer significantly impact the cycle outcome?

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The effects of chemical and physical factors on mammalian embryo culture and their importance for the practice of assisted human reproduction

Petra L. Wale et al.

HUMAN REPRODUCTION UPDATE (2016)

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Endometrial microbiome at the time of embryo transfer: next-generation sequencing of the 16S ribosomal subunit

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JOURNAL OF ASSISTED REPRODUCTION AND GENETICS (2016)

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Obesity and Bariatric Surgery Drive Epigenetic Variation of Spermatozoa in Humans

Ida Donkin et al.

CELL METABOLISM (2016)

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Impact of multinucleated blastomeres on embryo developmental competence, morphokinetics, and aneuploidy

Hanna Balakier et al.

FERTILITY AND STERILITY (2016)

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MicroRNAs in spent blastocyst culture medium are derived from trophectoderm cells and can be explored for human embryo reproductive competence assessment

Antonio Capalbo et al.

FERTILITY AND STERILITY (2016)

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A new more detailed stratification of low responders to ovarian stimulation: from a poor ovarian response to a low prognosis concept

Carlo Alviggi et al.

FERTILITY AND STERILITY (2016)

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Sequential versus Monophasic Media Impact Trial (SuMMIT): a paired randomized controlled trial comparing a sequential media system to a monophasic medium

Marie D. Werner et al.

FERTILITY AND STERILITY (2016)

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Follicular versus luteal phase ovarian stimulation during the same menstrual cycle (DuoStim) in a reduced ovarian reserve population results in a similar euploid blastocyst formation rate: new insight in ovarian reserve exploitation

Filippo Maria Ubaldi et al.

FERTILITY AND STERILITY (2016)

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Correlation between aneuploidy, standard morphology evaluation and morphokinetic development in 1730 biopsied blastocysts: a consecutive case series study

Maria Giulia Minasi et al.

HUMAN REPRODUCTION (2016)

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Reproductive outcome is optimized by genomic embryo screening, vitrification, and subsequent transfer into a prepared synchronous endometrium

Jorge Rodriguez-Purata et al.

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS (2016)

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Correction Genetics & Heredity

Serum progesterone levels greater than 20 ng/ml on day of embryo transfer are associated with lower live birth and higher pregnancy loss rates (vol 32, pg 1395, 2015)

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JOURNAL OF ASSISTED REPRODUCTION AND GENETICS (2016)

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The endometrial preparation for frozen-thawed euploid blastocyst transfer: a prospective randomized trial comparing clinical results from natural modified cycle and exogenous hormone stimulation with GnRH agonist

Ermanno Greco et al.

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS (2016)

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Corona cell RNA sequencing from individual oocytes revealed transcripts and pathways linked to euploid oocyte competence and live birth

Jason C. Parks et al.

REPRODUCTIVE BIOMEDICINE ONLINE (2016)

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Does slow embryo development predict a high aneuploidy rate on trophectoderm biopsy?

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REPRODUCTIVE BIOMEDICINE ONLINE (2016)

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A pilot proof-of-principle study to compare fresh and vitrified cycle preimplantation genetic screening by chromosome microarray and next generation sequencing

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MOLECULAR CYTOGENETICS (2016)

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The Impact of Biopsy on Human Embryo Developmental Potential during Preimplantation Genetic Diagnosis

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BIOMED RESEARCH INTERNATIONAL (2016)

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High relative deoxyribonucleic acid content of trophectoderm biopsy adversely affects pregnancy outcomes

Shelby A. Neal et al.

FERTILITY AND STERILITY (2016)

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Letter Obstetrics & Gynecology

A biochemical view: vitamin D levels do not affect in vitro fertilization outcomes following the transfer of euploid blastocysts

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AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2015)

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A biochemical view: vitamin D levels do not affect in vitro fertilization outcomes following the transfer of euploid blastocysts REPLY

Jason M. Franasiak et al.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2015)

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Vitamin D levels do not affect IVF outcomes following the transfer of euploid blastocysts

Jason M. Franasiak et al.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2015)

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Morphokinetics as a predictor of self-correction to diploidy in tripronucleated intracytoplasmic sperm injection-derived human embryos

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FERTILITY AND STERILITY (2015)

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Long-term cryopreservation of human oocytes does not increase embryonic aneuploidy

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FERTILITY AND STERILITY (2015)

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Comprehensive chromosome screening improves embryo selection: a meta-analysis

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FERTILITY AND STERILITY (2015)

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Mitochondrial DNA content as a viability score in human euploid embryos: less is better

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FERTILITY AND STERILITY (2015)

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Reduction of multiple pregnancies in the advanced maternal age population after implementation of an elective single embryo transfer policy coupled with enhanced embryo selection: pre- and post-intervention study

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HUMAN REPRODUCTION (2015)

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HUMAN REPRODUCTION UPDATE (2015)

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Endometrial disruption does not improve implantation in patients who have failed the transfer of euploid blastocysts

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JOURNAL OF ASSISTED REPRODUCTION AND GENETICS (2015)

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Investigating the optimal preconception TSH range for patients undergoing IVF when controlling for embryo quality

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JOURNAL OF ASSISTED REPRODUCTION AND GENETICS (2015)

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Oocyte versus embryo cryopreservation for fertility preservation in cancer patients: guaranteeing a women's autonomy

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JOURNAL OF ASSISTED REPRODUCTION AND GENETICS (2015)

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Serum progesterone levels greater than 20 ng/dl on day of embryo transfer are associated with lower live birth and higher pregnancy loss rates

Jason D. Kofinas et al.

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS (2015)

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In vitro fertilization with preimplantation genetic screening improves implantation and live birth in women age 40 through 43

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JOURNAL OF ASSISTED REPRODUCTION AND GENETICS (2015)

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Mitochondrial DNA Assessment to Determine Oocyte and Embryo Viability

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SEMINARS IN REPRODUCTIVE MEDICINE (2015)

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How should we choose the 'best' embryo? A commentary on behalf of the British Fertility Society and the Association of Clinical Embryologists

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Altered Levels of Mitochondrial DNA Are Associated with Female Age, Aneuploidy, and Provide an Independent Measure of Embryonic Implantation Potential

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Can Comprehensive Chromosome Screening Technology Improve IVF/ICSI Outcomes? A Meta-Analysis

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Technical Update: Preimplantation Genetic Diagnosis and Screening

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The Human Endometrium as a Sensor of Embryo Quality1

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BIOLOGY OF REPRODUCTION (2014)

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Selection of competent blastocysts for transfer by combining time-lapse monitoring and array CGH testing for patients undergoing preimplantation genetic screening: a prospective study with sibling oocytes

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BMC MEDICAL GENOMICS (2014)

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Blastocyst euploidy and implantation rates in a young (<35 years) and old (≥35 years) presumed fertile and infertile patient population

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FERTILITY AND STERILITY (2014)

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Examining the temperature of embryo culture in in vitro fertilization: a randomized controlled trial comparing traditional core temperature (37°C) to a more physiologic, cooler temperature (36°C)

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The role of the osteopontin-integrin αvβ3 interaction at implantation: functional analysis using three different in vitro models

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Proposed guidelines on the nomenclature and annotation of dynamic human embryo monitoring by a time-lapse user group

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HUMAN REPRODUCTION (2014)

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Correlation between standard blastocyst morphology, euploidy and implantation: an observational study in two centers involving 956 screened blastocysts

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HUMAN REPRODUCTION (2014)

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Morphological and cytogenetic assessment of cleavage and blastocyst stage embryos

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MOLECULAR HUMAN REPRODUCTION (2014)

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Outcomes of blastocysts biopsied and vitrified once versus those cryopreserved twice for euploid blastocyst transfer

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REPRODUCTIVE BIOMEDICINE ONLINE (2014)

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Comparison of aneuploidy, pregnancy and live birth rates between day 5 and day 6 blastocysts

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REPRODUCTIVE BIOMEDICINE ONLINE (2014)

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SCIENTIFIC REPORTS (2014)

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Comparative Genomic Hybridization Selection of Blastocysts for Repeated Implantation Failure Treatment: A Pilot Study

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BIOMED RESEARCH INTERNATIONAL (2014)

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Corpus luteal contribution to maternal pregnancy physiology and outcomes in assisted reproductive technologies\

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AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2013)

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Analysis of metabolism to select viable human embryos for transfer

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Diminished effect of maternal age on implantation after preimplantation genetic diagnosis with array comparative genomic hybridization

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FERTILITY AND STERILITY (2013)

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Cleavage-stage biopsy significantly impairs human embryonic implantation potential while blastocyst biopsy does not: a randomized and paired clinical trial

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OBSTETRICS AND GYNECOLOGY (2013)

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Comprehensive chromosome screening is highly predictive of the reproductive potential of human embryos: a prospective, blinded, nonselection study

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FERTILITY AND STERILITY (2012)

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Oocyte vitrification does not increase the risk of embryonic aneuploidy or diminish the implantation potential of blastocysts created after intracytoplasmic sperm injection: a novel, paired randomized controlled trial using DNA fingerprinting

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Administration of calcitonin promotes blastocyst implantation in mice by up-regulating integrin β3 expression in endometrial epithelial cells

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The Istanbul consensus workshop on embryo assessment: proceedings of an expert meeting

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Istanbul consensus workshop on embryo assessment: proceedings of an expert meeting

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AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2010)

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Prospective cohort study in high responder oocyte donors using two hormonal stimulation protocols: impact on embryo aneuploidy and development

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Metabolism of the viable mammalian embryo: quietness revisited

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Embryo viability and metabolism: obeying the quiet rules

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Understanding cellular disruptions during early embryo development that perturb viability and fetal development

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REPRODUCTION FERTILITY AND DEVELOPMENT (2005)

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ESHRE PGD Consortium 'best practice guidelines for clinical preimplantation genetic diagnosis (PGD) and preimplantation genetic screening (PGS)'

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Blastocyst score affects implantation and pregnancy outcome: towards a single blastocyst transfer

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FERTILITY AND STERILITY (2000)

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Opening the black box: why do euploid blastocysts fail to implant? A systematic review and meta-analysis

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