Recurrent PAK2 rearrangements in poroma with folliculo-sebaceous differentiation

Article Cell Biology

Distinct regulations driving YAP1 expression loss in poroma, porocarcinoma and RB1-deficient skin carcinoma

Thibault Kervarrec et al.

Summary: Recent research has shown the presence of YAP1 fusion genes in eccrine poroma and porocarcinoma. The use of YAP1 immunohistochemistry for diagnosis has been emphasized. The study aimed to evaluate the performance of YAP1 immunohistochemistry in the diagnosis of these tumors. The results showed that YAP1 expression was lost in a significant number of cases, and inactivation of RB1 was associated with transcriptional repression of YAP1.

HISTOPATHOLOGY (2023)

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Article Dermatology

Poroma: A Retrospective Series of 80 Patients at a Tertiary Care Hospital

C. Moreno-Vilchez et al.

Summary: This retrospective study analyzed patients with poroma between 2002 and 2021. The results showed that poroma lesions were more common in the lower extremities and acral sites. Women were more likely to have scalp lesions, and acral lesions were more likely to be erythematous. Overall, poroma is a heterogeneous tumor with different clinical characteristics, with acral lesions being more common.

ACTAS DERMO-SIFILIOGRAFICAS (2023)

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Review Oncology

Recent Advances on Immunohistochemistry and Molecular Biology for the Diagnosis of Adnexal Sweat Gland Tumors

Nicolas Macagno et al.

Summary: Cutaneous sweat gland tumors are a diverse and heterogeneous group of neoplasms that differentiate into the sweat apparatus. Their rarity, complexity, and challenging terminology make their pathological diagnosis difficult. Recent research has discovered a wide range of oncogenic drivers, many of which have diagnostic value for pathologists. These molecular alterations, mostly represented by gene fusions, are shared with homologous tumors in organs containing exocrine glands like salivary and breast glands, which have similarities to the sweat apparatus. This review aims to provide a synthesis of the most recent immunohistochemical and molecular markers used for the diagnosis of sweat gland tumors and their relationship with similar tumors in other organs.

CANCERS (2022)

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Review Biochemistry & Molecular Biology

New Therapeutic Opportunities for the Treatment of Squamous Cell Carcinomas: A Focus on Novel Driver Kinases

Ryan Bensen et al.

Summary: Squamous cell carcinomas of the lung, head and neck, esophagus, and cervix have common genetic alterations, with 3q chromosome amplification being a distinguishing feature. Over 20% of clinical squamous cell carcinoma samples show amplification of genes in this region, which correlates with decreased overall patient survival. The dependency of cancer cells on these amplified kinases suggests a potential for personalized medicine through targeting them with small molecules.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Medicine, Research & Experimental