Effect of opioids for breathlessness in heart failure: a systematic review and meta-analysis

Article Clinical Neurology

Genetic and Clinical Factors Associated with Opioid Response in Chinese Han Patients with Cancer Pain: An Exploratory Cross-Sectional Study

Chen Shi et al.

Summary: This study reveals that constructing multidimensional gene-environment interactions enables better interpretations of the effect of genetic variation and environmental factors on opioid response in patients with cancer pain.

PAIN AND THERAPY (2022)

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Review Health Care Sciences & Services

Multi-Dimensional Dyspnea-Related Scales Validated in Individuals With Cardio-Respiratory and Cancer Diseases. A Systematic Review of Psychometric Properties

Stefania Tinti et al.

Summary: This study aimed to identify multi-dimensional clinical scales assessing dyspnea and its impact on ADLs in patients with cardio-respiratory and cancer diseases, and critically appraise their psychometric properties. Findings revealed limited evidence on the psychometric properties of most scales, despite the availability of multiple assessment scales for dyspnea. Further research is needed to enhance the validity and reliability evidence of the identified multi-dimensional dyspnea scales.

JOURNAL OF PAIN AND SYMPTOM MANAGEMENT (2022)

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Article Cardiac & Cardiovascular Systems

Midazolam versus morphine in acute cardiogenic pulmonary oedema: results of a multicentre, open-label, randomized controlled trial

Alberto Dominguez-Rodriguez et al.

Summary: In the study of treating ACPE patients, there was no significant difference in reducing mortality between midazolam and morphine, but the midazolam group had a significantly lower rate of serious adverse events.

EUROPEAN JOURNAL OF HEART FAILURE (2022)

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Review Cardiac & Cardiovascular Systems

The Risk of Mortality Associated With Opioid Use in Patients With Acute Heart Failure: Systematic Review and Meta-analysis

Daniel Gao et al.

Summary: The use of opioids in acute heart failure patients appears to be associated with increased risk of in-hospital and 30-day mortality, although the confidence in this finding is very low due to serious bias risk and low quality of evidence. Further research is needed to verify these results.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

Differences between patients with cardiovascular disease and cancer referred for palliative care

Haider J. Warraich et al.

Summary: Compared to cancer patients, cardiovascular disease patients referred to palliative care are older, have worse functional status, and clinician-estimated prognosis. However, both groups experience high symptom burden, with cardiovascular disease patients more commonly having dyspnea, while pain, nausea, and fatigue are more common in cancer patients.

AMERICAN HEART JOURNAL (2021)

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Review Medicine, General & Internal

The PRISMA 2020 statement: an updated guideline for reporting systematic reviews

Matthew J. Page et al.

Summary: The PRISMA statement was designed to help systematic reviewers transparently report the purpose, methods, and findings of their reviews. The updated PRISMA 2020 statement includes new reporting guidance, a 27-item checklist, an abstract checklist, and revised flow diagrams for reviews.

BMJ-BRITISH MEDICAL JOURNAL (2021)

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Review Cardiac & Cardiovascular Systems

The safety of morphine in patients with acute heart failure: A systematic review and meta-analysis

Dandan Zhang et al.

Summary: The use of morphine in patients with acute heart failure was not associated with increased in-hospital mortality but significantly increased the risk of invasive ventilation and long-term mortality. Further confirmation of these findings is needed through an ongoing randomized control trial.

CLINICAL CARDIOLOGY (2021)

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Review Cardiac & Cardiovascular Systems

Intravenous morphine use in acute heart failure increases adverse outcomes: a meta-analysis

Yaowang Lin et al.

Summary: This study compared the efficacy of intravenous morphine treatment with no morphine treatment in patients with acute heart failure (AHF). The findings suggest that intravenous morphine treatment may be associated with in-hospital mortality in AHF patients, but does not have an impact on invasive mechanical ventilation or long-term mortality.

REVIEWS IN CARDIOVASCULAR MEDICINE (2021)

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Review Respiratory System

Mechanisms underlying the sensation of dyspnea

Isato Fukushi et al.

Summary: Dyspnea is a subjective experience of breathing discomfort that is common among patients with respiratory diseases. The underlying mechanisms are poorly understood, but it may result from a disconnect or mismatch between intended respiratory motor output and actual ventilatory output caused by the respiratory neuronal network.

RESPIRATORY INVESTIGATION (2021)

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Article Neurosciences