4.6 Article

ARID1A deficiency is targetable by AKT inhibitors in HER2-negative gastric cancer

Related references

Note: Only part of the references are listed.
Article Gastroenterology & Hepatology

Loss of ARID1A activates mTOR signaling and SOX9 in gastric adenocarcinoma-rationale for targeting ARID1A deficiency

Xiaochuan Dong et al.

Summary: Genetic alterations in ARID1A were found in over 30% of gastric adenocarcinoma cases, and the loss of ARID1A leads to activation of the mTOR pathway and increased sensitivity to mTOR inhibitors, suggesting a new therapeutic strategy for targeting the mTOR pathway in patients with gastric adenocarcinoma with ARID1A deficiency.
Article Oncology

Selective sensitivity of EZH2 inhibitors based on synthetic lethality in ARID1A-deficient gastric cancer

Leo Yamada et al.

Summary: EZH2 inhibitors show selective sensitivity against ARID1A-deficient GC cells, potentially affecting cell survival and proliferation by modulating the PI3K/AKT signaling pathway. This suggests the potential efficacy of targeted therapy using EZH2 inhibitors in ARID1A-deficient GC.

GASTRIC CANCER (2021)

Article Oncology

ARID1A deficiency in EBV-positive gastric cancer is partially regulated by EBV-encoded miRNAs, but not by DNA promotor hypermethylation

Koji Kase et al.

Summary: In EBV (+) GC, miR-BART11-3p and miR-BART12 regulate ARID1A expression through epigenetic modifications, potentially reducing ARID1A levels, with their expression correlated with ARID1A levels in GC tumors.

CARCINOGENESIS (2021)

Article Multidisciplinary Sciences

PD-L1 overexpression in EBV-positive gastric cancer is caused by unique genomic or epigenomic mechanisms

Hiroshi Nakano et al.

Summary: Epstein-Barr virus-positive gastric cancer (EBV (+) GC) exhibits overexpression of PD-L1 through a unique dual mechanism: focal amplification of CD274 or IFN-gamma-mediated signaling via activation of IRF3, correlating with CD8 lymphocyte infiltration and IRF3 signature expression in tumor tissue and infiltrating immune cells.

SCIENTIFIC REPORTS (2021)

Review Oncology

Trastuzumab deruxtecan for the treatment of HER2-positive advanced gastric cancer: a clinical perspective

Masahiko Aoki et al.

Summary: T-DXd, a novel HER2-targeted antibody-drug conjugate, shows high response rates and significant survival benefits in HER2-positive gastric cancer treatment, and exhibits anti-tumor activity to HER2-negative tumor cells. Its efficacy has been demonstrated in several clinical studies, indicating potential for further progress in treatment of both strongly and weakly HER2 positive gastric cancer.

GASTRIC CANCER (2021)

Review Oncology

Discovery and development of trastuzumab deruxtecan and safety management for patients with HER2-positive gastric cancer

Kohei Shitara et al.

Summary: Approximately 12-15% of gastric cancers are HER2-positive, with trastuzumab being the standard treatment. However, other HER2-targeted therapies have not shown survival benefits, including an antibody-drug conjugate consisting of an anti-HER2 antibody with a topoisomerase I inhibitor. The high drug-antibody ratio and bystander antitumor effect of the drug make it an effective treatment option for HER2-positive gastric cancer.

GASTRIC CANCER (2021)

Review Oncology

Landscape of EBV-positive gastric cancer

Motonobu Saito et al.

Summary: Epstein-Barr virus-positive gastric cancer (EBV (+) GC) is a subtype of GC associated with EBV infection, exhibiting unique genomic and clinicopathological features compared to other subtypes. Noncoding RNAs derived from EBV-infected cells play crucial roles in oncogenesis and tumor progression in EBV (+) GC. Recent studies focus on genetic mutations and protein overexpression in EBV (+) GC, proposing potential targeted therapies for this subtype.

GASTRIC CANCER (2021)

Article Medicine, General & Internal

First-line nivolumab plus chemotherapy versus chemotherapy alone for advanced gastric, gastro-oesophageal junction, and oesophageal adenocarcinoma (CheckMate 649): a randomised, open-label, phase 3 trial

Yelena Y. Janjigian et al.

Summary: Nivolumab plus chemotherapy showed superior overall survival and progression-free survival compared to chemotherapy alone in previously untreated patients with advanced gastric, gastro-oesophageal junction, or oesophageal adenocarcinoma, indicating it as a new standard first-line treatment option with acceptable safety profile.

LANCET (2021)

Article Multidisciplinary Sciences

The effects of T-DXd on the expression of HLA class I and chemokines CXCL9/10/11 in HER2-overexpressing gastric cancer cells

Shotaro Nakajima et al.

Summary: Trastuzumab deruxtecan (T-DXd) exhibits an excellent anti-tumor effect through increasing the number of tumor-infiltrating CD8(+) T cells and enhancing major-histocompatibility-complex class I expression in a mouse model. However, its impact on anti-tumor immune responses in human cancers remains largely unknown.

SCIENTIFIC REPORTS (2021)

Review Oncology

Current status of immune checkpoint inhibitors for gastric cancer

Koji Kono et al.

GASTRIC CANCER (2020)

Review Oncology

Molecular target: pan-AKT in gastric cancer

Byung Woog Kang et al.

ESMO OPEN (2020)

Article Multidisciplinary Sciences

Prognostic role of ARID1A negative expression in gastric cancer

Mai Ashizawa et al.

SCIENTIFIC REPORTS (2019)

Review Oncology

Targeted and novel therapy in advanced gastric cancer

Julie H. Selim et al.

EXPERIMENTAL HEMATOLOGY & ONCOLOGY (2019)

Review Oncology

NTRK fusion-positive cancers and TRK inhibitor therapy

Emiliano Cocco et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2018)

Article Oncology

Genomic Amplification of CD274 (PD-L1) in Small-Cell Lung Cancer

Julie George et al.

CLINICAL CANCER RESEARCH (2017)

Article Oncology

Estimation of lifetime cumulative incidence and mortality risk of gastric cancer

Yukari Taniyama et al.

JAPANESE JOURNAL OF CLINICAL ONCOLOGY (2017)

Article Multidisciplinary Sciences

Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade

Dung T. Le et al.

SCIENCE (2017)

Article Biotechnology & Applied Microbiology

AKT inhibition is an effective treatment strategy in ARID1A-deficient gastric cancer cells

Dakeun Lee et al.

ONCOTARGETS AND THERAPY (2017)

Article Biochemistry & Molecular Biology

Molecular analysis of gastric cancer identifies subtypes associated with distinct clinical outcomes

Razvan Cristescu et al.

NATURE MEDICINE (2015)

Review Medicine, General & Internal

Recent advances in the HER2 targeted therapy of gastric cancer

Tasuku Matsuoka et al.

WORLD JOURNAL OF CLINICAL CASES (2015)

Article Oncology

Significance of AKT in gastric cancer (Review)

Takamitsu Sasaki et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2014)

Article Multidisciplinary Sciences

Comprehensive molecular characterization of gastric adenocarcinoma

Adam J. Bass et al.

NATURE (2014)

Review Oncology

The Role of PI3K/Akt/mTOR Signaling in Gastric Carcinoma

Tasuku Matsuoka et al.

CANCERS (2014)