Journal
FOOD CHEMISTRY
Volume 404, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2022.134710
Keywords
Pediococcus acidilactici MNL5; Fermented onion extracts; Lipase inhibitory activity; Quercetin; Lipid reduction
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The bioconversion of onion extracts with P. acidilactici MNL5 enhances metabolites and has a synergistic lipid-reduction impact for anti-obesity studies. The fermented onion extracts show enhanced inhibitory activity against pancreatic lipase and increased antioxidant properties compared to raw onion extract.
The bioconversion of onion extracts with P. acidilactici MNL5 enhances the metabolites and has a synergistic lipid-reduction impact that is beneficial for anti-obesity studies. The 48 h fermented onion extracts (FOE) demonstrated an enhanced inhibitory activity against pancreatic lipase (89.5 +/- 1.25 %) as compared to the raw onion extract (ROE) (33.4 +/- 0.86 %). The antioxidant properties of FOE significantly increased compared to the ROE inhibitory effect on DPPH (99.5 +/- 2.40 mg vitamin C equiv./mg, DW FOE), and ABTS (104.5 +/- 2.32 mg vitamin C equiv./mg, DW FOE). Based on FOE's higher antioxidant activity, UHPLC-Q-TOF-MS/MS demon-strated dramatic changes in the untargeted metabolite profile as compared to ROE. Moreover, C. elegans sup-plemented with FOE and quercetin exhibited an enhanced lifespan activity, lipid reduction, and decreased triglycerides. FOE can lower cholesterol and enhance quercetin to promote pancreatic lipase activity for syn-ergistic anti-obesity effects.
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