Journal
FITOTERAPIA
Volume 165, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.fitote.2022.105393
Keywords
Cornus officinalis Sieb; Et Zucc; Iridoid glycosides; Structure elucidation; Antidiabetic activity
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Four novel iridoid glycosides and nine known ones were isolated from Cornus officinalis fruits. These compounds exhibited antidiabetic activities in insulin-resistant HepG2 cells.
Four novel iridoid glycosides neocornuside E-H (1-4), together with nine known ones (5-13), were isolated from fruits of Cornus officinalis. Their chemical structures were determined on the basis of spectroscopic analyses and comparing of the literature data. All of the isolated compounds were evaluated for their antidiabetic activity in insulin resistant HepG2 cells. Compounds 2, 4, 5, 8, and 12 exhibited antidiabetic activities with EC50 values of 40.12, 2.54, 70.43, 15.31, and 4.86 mu M, respectively. Flow Sight cytometry analysis indicated that compounds 2, 4, 5, 8, and 12 improved the ability of 2-NBDG uptake of insulin-induced HepG2 cells.
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