Unreported ent-rosane diterpenes from Croton niveus Jacq. (Euphorbiaceae). Cytotoxic activity and docking studies

From the bioactive extract of the euphorbiaceous Croton niveus Jacq., three previously unreported ent-rosane diterpenes have been isolated and characterized by conventional methods, in addition to the known compounds lupeol, cajucarinolide and some phytosterols. Two of the ent-rosane diterpenes displayed activity against HCT-15 and PC-3 cancer cell lines, and the results of docking calculations of these compounds with NF-& kappa;B and STAT3 receptors agreed with the proposed mode of action of diterpenes against PC-3 cells.

Automated summary

Three new ent-rosane diterpenes were isolated and characterized from the bioactive extract of Croton niveus Jacq., along with known compounds lupeol, cajucarinolide, and phytosterols. Two of the ent-rosane diterpenes exhibited activity against HCT-15 and PC-3 cancer cell lines, and docking calculations supported their proposed mode of action against PC-3 cells by interacting with NF-κB and STAT3 receptors.