4.8 Article

Nanoparticle-Loaded Protein-Polymer Nanodroplets for Improved Stability and Conversion Efficiency in Ultrasound Imaging and Drug Delivery

Journal

ADVANCED MATERIALS
Volume 27, Issue 37, Pages 5484-5492

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201502022

Keywords

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Funding

  1. Engineering and Physical Sciences Research Council [EP/I021795/1]
  2. RCUK (Oxford Centre for Doctoral Training in Healthcare Innovation) [EP/G036861/1]
  3. EPSRC [EP/L024012/1, EP/I021795/1] Funding Source: UKRI
  4. Engineering and Physical Sciences Research Council [1104432, EP/L024012/1, EP/I021795/1] Funding Source: researchfish

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A new formulation of volatile nanodropletsstabilized by a protein and polymer coating and loaded with magnetic nanoparticles is developed. The droplets show enhanced stability and phase conversion efficiency upon ultrasound exposure compared with existing formulations. Magnetic targeting, encapsulation, and release of an anticancer drug are demonstrated in vitro with a 40% improvement in cytotoxicity compared with free drug.

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