4.7 Article

Integrative transcriptomics and cell systems analyses reveal protective pathways controlled by Igfbp-3 in anthracycline-induced cardiotoxicity

Related references

Note: Only part of the references are listed.
Article Cell Biology

Trajectory reconstruction identifies dysregulation of perinatal maturation programs in pluripotent stem cell-derived cardiomyocytes

Suraj Kannan et al.

Summary: A limitation in the application of pluripotent stem cell-derived cardiomyocytes (PSC-CMs) is their failure to achieve full functional maturity. In this study, the authors generated reference maps of mouse in vivo cardiomyocyte maturation and PSC-CM-directed differentiation through single-cell RNA sequencing. They identified an endogenous perinatal maturation program that is poorly recapitulated in vitro and uncovered a network of nine transcription factors consistently dysregulated in PSC-CMs across species. These findings have implications for improving the clinical viability of PSC-CMs.

CELL REPORTS (2023)

Article Biochemistry & Molecular Biology

Implication of SphingolipidMetabolismGene Dysregulation and Cardiac Sphingosine-1-Phosphate Accumulation in Heart Failure

Lorena Perez-Carrillo et al.

Summary: Disturbances in sphingolipid metabolism contribute to the development of heart failure by causing an accumulation of ceramide and S1P in cardiac tissue, as well as an increase in the ceramide/S1P ratio. Therapeutic gene modulation aimed at restoring ceramide levels or reversing the ceramide/S1P ratio could be a potential treatment strategy for heart failure patients.

BIOMEDICINES (2022)

Article Biochemistry & Molecular Biology

Mammalian monocarboxylate transporter 7 (MCT7/Slc16a6) is a novel facilitative taurine transporter

Kei Higuchi et al.

Summary: Monocarboxylate transporter 7 (MCT7) is a transporter expressed in the liver, brain, and several types of cancer cells. It has been reported to be a survival factor in melanoma and breast cancers. This study reveals that MCT7 may function as a low-affinity facilitative taurine transporter and its interaction with ancillary proteins enhances taurine transport.

JOURNAL OF BIOLOGICAL CHEMISTRY (2022)

Review Cardiac & Cardiovascular Systems

Anthracycline-induced cardiotoxicity: From pathobiology to identification of molecular targets for nuclear imaging

Jeremy Jong et al.

Summary: Anthracycline-induced cardiotoxicity is a common side effect in chemotherapy, and current imaging modalities have limitations in screening for toxicity. Therefore, researchers have studied molecular nuclear imaging strategies to improve the accuracy of detecting cardiotoxicity. Based on the current evidence, molecular nuclear imaging plays an important role in improving patient management.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2022)

Article Physiology

Cardiac fibrosis in oncologic therapies

Rene R. Sevag Packard

Summary: Cardiotoxicity, a potential side-effect of oncologic therapies, can lead to the development of cardiac fibrosis, which increases the risk of cardiac dysfunction and cardiovascular mortality. This review focuses on the mechanisms of fibroblast activation, myofibroblast transdifferentiation, and the development of cardiac fibrosis as a consequence of cancer treatments. It also discusses clinical strategies for assessing cardiac fibrosis and emerging therapies to prevent or treat fibrosis.

CURRENT OPINION IN PHYSIOLOGY (2022)

Article Cardiac & Cardiovascular Systems

Proteomic and Functional Studies Reveal Detyrosinated Tubulin as Treatment Target in Sarcomere Mutation-Induced Hypertrophic Cardiomyopathy

Maike Schuldt et al.

Summary: The study found that microtubules and their detyrosination play an important role in the pathomechanism of patients with HCMSMP, potentially serving as a target for improving cardiac function. However, the beneficial effect may be limited in patients with HCMSMN.

CIRCULATION-HEART FAILURE (2021)

Article Medicine, Research & Experimental

Metabolic reprogramming and epigenetic changes of vital organs in SARS-CoV-2-induced systemic toxicity

Shen Li et al.

Summary: The authors successfully reproduced the systemic toxicity and multiorgan involvement induced by SARS-CoV-2 in a mouse model through viral delivery, revealing that metabolic and epigenetic changes could contribute to the pathogenesis of COVID-19.

JCI INSIGHT (2021)

Article Multidisciplinary Sciences

PGC1/PPAR drive cardiomyocyte maturation at single cell level via YAP1 and SF3B2

Sean A. Murphy et al.

Summary: Cardiomyocyte maturation and the acquisition of phenotypes at the single cell level were analyzed in this study, revealing that peroxisome proliferator-activated receptor coactivator-1 mediates the phenotypic shift. The study provides a single-cell roadmap of heterogeneous transitions coupled to cellular features.

NATURE COMMUNICATIONS (2021)

Article Biochemistry & Molecular Biology

Integrated analysis of multimodal single-cell data

Yuhan Hao et al.

Summary: The study introduces a weighted-nearest neighbor analysis framework to learn the relative utility of each data type in each cell, enabling integrative analysis of multiple modalities. Applied to a CITE-seq dataset, the method constructs a multimodal reference atlas of the circulating immune system and successfully identifies and validates previously unreported lymphoid subpopulations.
Article Cell Biology

WDR47 protects neuronal microtubule minus ends from katanin-mediated severing

Robin R. Buijs et al.

Summary: Experimental evidence shows that the neuron-enriched protein WDR47 interacts with CAMSAPs, playing a critical role in axon and dendrite development. WDR47 accumulates at CAMSAP2-decorated microtubules, maintaining CAMSAP2 stretches and protecting minus ends from katanin-mediated severing.

CELL REPORTS (2021)

Article Cardiac & Cardiovascular Systems

Depletion of Vasohibin 1 Speeds Contraction and Relaxation in Failing Human Cardiomyocytes

Christina Yingxian Chen et al.

CIRCULATION RESEARCH (2020)

Review Cardiac & Cardiovascular Systems

Cardiomyocyte Maturation New Phase in Development

Yuxuan Guo et al.

CIRCULATION RESEARCH (2020)

Review Cardiac & Cardiovascular Systems

Cardiac natriuretic peptides

Jens P. Goetze et al.

NATURE REVIEWS CARDIOLOGY (2020)

Article Biochemistry & Molecular Biology

Comprehensive Integration of Single-Cell Data

Tim Stuart et al.

Review Toxicology

Oxidative stress injury in doxorubicin-induced cardiotoxicity

Mei Songbo et al.

TOXICOLOGY LETTERS (2019)

Article Biochemistry & Molecular Biology

IGFBP-3 interacts with NONO and SFPQ in PARP-dependent DNA damage repair in triple-negative breast cancer

Hasanthi C. de Silva et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2019)

Article Biotechnology & Applied Microbiology

Integrating single-cell transcriptomic data across different conditions, technologies, and species

Andrew Butler et al.

NATURE BIOTECHNOLOGY (2018)

Article Biochemistry & Molecular Biology

Suppression of detyrosinated microtubules improves cardiomyocyte function in human heart failure

Christina Yingxian Chen et al.

NATURE MEDICINE (2018)

Article Cardiac & Cardiovascular Systems

HDAC6 inhibition protects cardiomyocytes against doxorubicin-induced acute damage by improving alpha-tubulin acetylation

Rui Song et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2018)

Article Biochemical Research Methods

Salmon provides fast and bias-aware quantification of transcript expression

Rob Patro et al.

NATURE METHODS (2017)

Article Biochemical Research Methods

Reversed graph embedding resolves complex single-cell trajectories

Xiaojie Qiu et al.

NATURE METHODS (2017)

Review Cardiac & Cardiovascular Systems

Anthracycline Chemotherapy and Cardiotoxicity

John V. McGowan et al.

CARDIOVASCULAR DRUGS AND THERAPY (2017)

Review Biochemistry & Molecular Biology

On the Dependency of Cellular Protein Levels on mRNA Abundance

Yansheng Liu et al.

Article Cardiac & Cardiovascular Systems

Catabolic Defect of Branched-Chain Amino Acids Promotes Heart Failure

Haipeng Sun et al.

CIRCULATION (2016)

Article Multidisciplinary Sciences

Detyrosinated microtubules buckle and bear load in contracting cardiomyocytes

Patrick Robison et al.

SCIENCE (2016)

Article Multidisciplinary Sciences

Regulation of endoplasmic reticulum turnover by selective autophagy

Aliaksandr Khaminets et al.

NATURE (2015)

Review Cardiac & Cardiovascular Systems

Cardiotoxicity of anticancer treatments

Michael S. Ewer et al.

NATURE REVIEWS CARDIOLOGY (2015)

Article Cardiac & Cardiovascular Systems

Cardiac-Specific YAP Activation Improves Cardiac Function and Survival in an Experimental Murine MI Model

Zhiqiang Lin et al.

CIRCULATION RESEARCH (2014)

Review Cell Biology

IGFBP-3: A cell fate pivot in cancer and disease

Michael A. Johnson et al.

GROWTH HORMONE & IGF RESEARCH (2014)

Article Medicine, Research & Experimental

Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation

Yoshihiko Ichikawa et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)

Review Cardiac & Cardiovascular Systems

Prevention of Anthracycline-Induced Cardiotoxicity

Pimprapa Vejpongsa et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2014)

Article Biotechnology & Applied Microbiology

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Michael I. Love et al.

GENOME BIOLOGY (2014)

Article Cardiac & Cardiovascular Systems

RalGDS-dependent cardiomyocyte autophagy is required for ventricular hypertrophy

Oktay F. Rifki et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2013)

Article Cell Biology

Insulin-like growth factor binding protein-3 (IGFBP-3): Novel ligands mediate unexpected functions

Robert C. Baxter

JOURNAL OF CELL COMMUNICATION AND SIGNALING (2013)

Article Biochemistry & Molecular Biology

Identification of the molecular basis of doxorubicin-induced cardiotoxicity

Sui Zhang et al.

NATURE MEDICINE (2012)

Article Multidisciplinary Sciences

Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling

Xiaojun Lian et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Biochemistry & Molecular Biology

IGFBP3 and BAG1 enhance radiation-induced apoptosis in squamous esophageal cancer cells

Kei Yoshino et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2011)

Article Cell Biology

The H9C2 cell line and primary neonatal cardiomyocyte cells show similar hypertrophic responses in vitro

Sarah J. Watkins et al.

IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL (2011)

Article Biochemistry & Molecular Biology

Positive Regulation of Apoptosis Signal-regulating Kinase 1 Signaling by ZPR9 Protein, a Zinc Finger Protein

Hyun-A Seong et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Biochemistry & Molecular Biology

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

Fabian Sievers et al.

MOLECULAR SYSTEMS BIOLOGY (2011)

Article Multidisciplinary Sciences

Global quantification of mammalian gene expression control

Bjoern Schwanhaeusser et al.

NATURE (2011)

Article Cardiac & Cardiovascular Systems

IL-10 attenuates TNF-α-induced NFκB pathway activation and cardiomyocyte apoptosis

Sanjiv Dhingra et al.

CARDIOVASCULAR RESEARCH (2009)

Article Biochemical Research Methods

WGCNA: an R package for weighted correlation network analysis

Peter Langfelder et al.

BMC BIOINFORMATICS (2008)

Article Cardiac & Cardiovascular Systems

Biglycan is required for adaptive remodeling after myocardial infarction

D. Westermann et al.

CIRCULATION (2008)

Article Biochemical Research Methods

Sulforhodamine B colorimetric assay for cytotoxicity screening

Vanicha Vichai et al.

NATURE PROTOCOLS (2006)

Article Multidisciplinary Sciences

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

A Subramanian et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Endocrinology & Metabolism

Insulin-like growth factor binding protein-3 mediates serum starvation- and doxorubicin-induced apoptosis in H9c2 cardiac cells

R Granata et al.

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION (2003)

Article Biochemistry & Molecular Biology

Structural and functional genomics of the CPT1B gene for muscle-type carnitine palmitoyltransferase I in mammals

FR van der Leij et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Biochemistry & Molecular Biology

A novel Rb- and p300-binding protein inhibits transactivation by MyoD

WR MacLellan et al.

MOLECULAR AND CELLULAR BIOLOGY (2000)