Journal
EXPERT REVIEW OF NEUROTHERAPEUTICS
Volume 23, Issue 6, Pages 559-565Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14737175.2023.2214315
Keywords
Electroencephalography; Pharmaco-EEG; epilepsy; anti-seizure medication; treatment response
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Despite advances in neuroimaging and genetics, electroencephalography (EEG) remains important for epilepsy diagnosis and management. Pharmaco-EEG is a sensitive technique for detecting drug effects on brain functioning and has potential in predicting the efficacy and tolerability of anti-seizure medications (ASMs).
IntroductionDespite recent advances in neuroimaging and genetics, electroencephalography (EEG) continues to play a central role in the diagnosis and management of epilepsy. One application of EEG is called pharmaco-EEG. This technique is highly sensitive in detecting the effects of drugs on brain functioning and shows potential in predicting the efficacy and tolerability of anti-seizure medications (ASMs).Areas coveredIn this narrative review, the authors discuss the most salient data concerning the effects of different ASMs on EEG. The authors aim to provide a clear and concise overview of the current state of research in this area, while also identifying opportunities for future investigation.Expert opinionTo date, pharmaco-EEG does not appear to be clinically reliable for predicting treatment response in epilepsy, as the literature is limited by underreporting of negative results, a lack of controls in many studies and insufficient direct replication of previous findings. Future research should focus on controlled interventional studies, which are currently lacking.
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