Major depressive disorder (mdd): emerging immune targets at preclinical level

BackgroundMajor depressive disorder is a mental health disorder that is characterized by a persistently low mood and loss of interest. MDD is affecting over 3.8% of the global population as a major health problem. Its etiology is complex, and involves the interaction between a number of factors, including genetic predisposition and the presence of environmental stresses.Areas coveredThe role of the immune and inflammatory systems in depression has been gaining interest, with evidence suggesting the potential involvement of pro-inflammatory molecules like TNF, interleukins, prostaglandins, and other cytokines, among others, has been put forth. Along with this, the potential of agents, from NSAIDs to antibiotics, are being evaluated in therapy for depression. The current review will discuss emerging immune targets at the preclinical level.Expert opinionWith increasing evidence to show that immune and inflammatory mediators are implicated in MDD, increasing research toward their potential as drug targets is encouraged. At the same time, agents acting on these mediators and possessing anti-inflammatory potential are also being evaluated as future therapeutic options for MDD, and increasing focus toward non-conventional drugs which can act through these mechanisms is important as regards the future prospects of the use of anti-inflammatory agents in depression.

Automated summary

Major depressive disorder (MDD) is a mental health disorder characterized by persistent low mood and loss of interest. The immune and inflammatory systems have been found to play a role in MDD, with evidence suggesting the involvement of pro-inflammatory molecules. Agents acting on these mediators and possessing anti-inflammatory potential are being evaluated as therapeutic options for MDD.