☆ 4.5 Review

Purposing plant-derived exosomes-like nanovesicles for drug delivery: patents and literature review

EXPERT OPINION ON THERAPEUTIC PATENTS (2023)

Related references

Note: Only part of the references are listed.
Review Chemistry, Multidisciplinary

Plant-Derived Vesicle-Like Nanoparticles as Promising Biotherapeutic Tools: Present and Future

Junjie Feng et al.

Summary: Extracellular vesicles (EVs) are biological particles that regulate cell communication and are secreted by almost all living cells, including plant cells. Plant-derived vesicle-like nanoparticles (PDVLNs) are vesicle-like nanostructure particles isolated from plants. PDVLNs have low immunogenicity and wide availability, making them safer and more economical to be developed as therapeutic agents and drug carriers. They play key roles in regulating interkingdom crosstalk between humans and plants and have great influence on human health and diseases.

ADVANCED MATERIALS (2023)

Add to Collection
Review Biochemistry & Molecular Biology

Plant-Derived Extracellular Vesicles as Therapeutic Nanocarriers

Theodora Karamanidou et al.

Summary: This review summarizes the progress in the use of plant-derived extracellular vesicles as therapeutic delivery systems. Despite some controversies, plant-derived EVs show significant potential as nanodelivery systems of natural origin.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Add to Collection
Article Chemistry, Multidisciplinary

Lemon-Derived Extracellular Vesicles Nanodrugs Enable to Efficiently Overcome Cancer Multidrug Resistance by Endocytosis-Triggered Energy Dissipation and Energy Production Reduction

Qian Xiao et al.

Summary: Researchers have developed a biomimetic drug delivery system based on lemon-derived extracellular vesicles (EVs) nanodrugs, which effectively overcomes multidrug resistance in cancer. By modifying functional heparin-cRGD (HR) onto the surface of EVs and loading them with doxorubicin (DOX), the researchers created HRED that can enter DOX-resistant cancer cells through various endocytosis pathways and exhibit excellent cellular uptake capacity. The HRED's diverse endocytosis capability dissipates intracellular energy and reduces ATP production, leading to a significant reduction in drug efflux. The authors believe that this strategy provides a new approach for designing drug delivery systems to overcome multidrug resistance in cancer.

ADVANCED SCIENCE (2022)

Add to Collection
Article Pharmacology & Pharmacy

Optimised Electroporation for Loading of Extracellular Vesicles with Doxorubicin

Angus J. Lennaard et al.

Summary: Extracellular vesicles (EVs) have the potential to overcome limitations in clinical use of chemotherapeutics. By optimizing the electroporation technique, drugs can be efficiently loaded into EVs, leading to improved drug transport efficacy and therapeutic potency with reduced adverse effects.

PHARMACEUTICS (2022)

Add to Collection
Article Biochemistry & Molecular Biology

An Apple a Day Keeps the Doctor Away: Potential Role of miRNA 146 on Macrophages Treated with Exosomes Derived from Apples

Martina Trentini et al.

Summary: The constant dialogue between the plant world and the animal world has a significant impact on human health, and apple exosomes have been found to possess anti-inflammatory effects in human cells and influence cell proliferation and death.

BIOMEDICINES (2022)

Add to Collection
Review Pharmacology & Pharmacy

Technology insight: Plant-derived vesicles-How far from the clinical biotherapeutics and therapeutic drug carriers?

Minghui Cong et al.

Summary: Plant extracellular vesicles (EVs) and exosome-like nanoparticles (ELNs) have emerged as important mediators of intercellular communication, with potential applications in biological processes regulation, disease prevention and treatment, and drug delivery. This review provides an overview of the development, techniques, biological activities, and clinical potential of plant EVs and ELNs, as well as the challenges and future directions in realizing their clinical transformation.

ADVANCED DRUG DELIVERY REVIEWS (2022)

Add to Collection
Article Biochemistry & Molecular Biology

Pancreatic Ductal Cell-Derived Extracellular Vesicles Are Effective Drug Carriers to Enhance Paclitaxel's Efficacy in Pancreatic Cancer Cells through Clathrin-Mediated Endocytosis

Haoyao Sun et al.

Summary: Chemo-resistance poses challenges in the clinical management of pancreatic ductal adenocarcinoma (PDAC). Limited drug uptake by PDAC tissues is a major barrier in chemotherapy for this malignancy. Small extracellular vesicles (sEVs) have shown potential as drug carriers for targeted delivery to tumor cells due to their low immunogenicity and affinity towards tumors. This study evaluated sEVs derived from different human cell lines as carriers for paclitaxel (PTX) and found that incubation with HPNE-derived sEVs led to the most effective killing of PDAC cells. The uptake of PTX-loaded sEVs was mediated via clathrin-dependent endocytosis. These results suggest that EVs derived from hTERT-HPNE cells are effective drug carriers to enhance the efficacy of paclitaxel in PDAC cells.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Add to Collection
Article Pharmacology & Pharmacy

Quantitative Biodistribution and Pharmacokinetics Study of GMP-Grade Exosomes Labeled with 89Zr Radioisotope in Mice and Rats

Hojun Choi et al.

Summary: This study assessed the biodistribution and pharmacokinetics of therapeutic exosomes labeled with Zr-89 in mice and rats. The results showed that the exosomes were mainly distributed in the liver and spleen, with substantial uptake by parenchymal cells. They were also moderately distributed in the kidney, lung, stomach, intestine, urinary bladder, brain, and heart. Exosomes were rapidly cleared from circulation, indicating their rapid uptake by cells and tissues.

PHARMACEUTICS (2022)

Add to Collection
Article Nanoscience & Nanotechnology

Mesenchymal Stem Cell Derived Exosomes as Nanodrug Carrier of Doxorubicin for Targeted Osteosarcoma Therapy via SDF1-CXCR4 Axis

Hongxiang Wei et al.

Summary: This study developed a nanodrug consisting of doxorubicin and exosome (Exo-Dox) derived from mesenchymal stem cells and investigated its antitumor activity, targeting capability, and mechanism through in vitro and in vivo experiments. The results showed that Exo-Dox exhibited higher cytotoxicity against osteosarcoma cells and less toxicity in heart tissue compared to free doxorubicin. MSC-derived exosomes could serve as efficient delivery vehicles for targeted drug delivery to osteosarcoma cells via the SDF1-CXCR4 axis.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2022)

Add to Collection
Article Biochemistry & Molecular Biology

Nanovesicles released by OKT3 hybridoma express fully active antibodies

Mariantonia Logozzi et al.

Summary: Nanovesicles contain immunoglobulins and can be used for immunotherapy, triggering cytokine production in T cells and potentially improving therapeutic antibody effectiveness.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2021)

Add to Collection
Review Biotechnology & Applied Microbiology

Plant Exosome-like Nanovesicles: Emerging Therapeutics and Drug Delivery Nanoplatforms

Haseeb Anwar Dad et al.

Summary: Plant exosome-like nanovesicles, rich in bioactive components, hold great potential in the fields of biotreatment and drug delivery, exhibiting immunomodulatory, antitumor, regenerative, and anti-inflammatory effects. Their physicochemical traits make them promising candidates for next-generation therapeutic and drug delivery nanoplatforms.

MOLECULAR THERAPY (2021)

Add to Collection
Article Chemistry, Multidisciplinary

A Biomimetic Drug Delivery System by Integrating Grapefruit Extracellular Vesicles and Doxorubicin-Loaded Heparin-Based Nanoparticles for Glioma Therapy

Wenbo Niu et al.

Summary: By patching doxorubicin-loaded heparin-based nanoparticles onto natural grapefruit extracellular vesicles, biomimetic EV-DNs can efficiently penetrate the blood brain barrier and blood-(brain tumor) barrier, achieving effective drug delivery and enhanced antiglioma efficacy.

NANO LETTERS (2021)

Add to Collection
Article Biochemistry & Molecular Biology

Exosome-mediated mRNA delivery in vivo is safe and can be used to induce SARS-CoV-2 immunity

Shang Jui Tsai et al.

Summary: Exosomes can be used as a promising delivery vehicle for functional mRNA, demonstrating efficient delivery to human cells and potential for clinical applications.

JOURNAL OF BIOLOGICAL CHEMISTRY (2021)

Add to Collection
Review Pharmacology & Pharmacy

Exosomes as Drug Delivery Systems: Endogenous Nanovehicles for Treatment of Systemic Lupus Erythematosus

Ana Ortega et al.

Summary: Exosomes, as nanometer-sized lipid-bilayer-enclosed extracellular vesicles, have shown promising potential as drug delivery vehicles with features like stability, biocompatibility, and low immunogenicity. They have been utilized for gene therapy and treating autoimmune diseases due to their ability to regulate immune signaling and inflammation.

PHARMACEUTICS (2021)

Add to Collection
Article Biochemistry & Molecular Biology

Strawberry-Derived Exosome-Like Nanoparticles Prevent Oxidative Stress in Human Mesenchymal Stromal Cells

Francesca Perut et al.

Summary: EPDENs isolated from strawberries have been shown to have potential health-promoting activities, including preventing oxidative stress in human mesenchymal stromal cells. The presence of vitamin C in the EPDEN membrane may contribute to this effect, along with the small RNAs and miRNAs found in the cargo. These findings suggest that Fragaria-derived EPDENs may serve as nanoshuttles in food with bioactive properties.

BIOMOLECULES (2021)

Add to Collection
Article Biochemistry & Molecular Biology

Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity

Wilfredo F. Garcia-Beltran et al.

Summary: New variants of SARS-CoV-2 show high resistance to vaccine neutralization, with some able to escape vaccine responses with just a few mutations, highlighting the importance of developing broadly protective measures against variants.

CELL (2021)

Add to Collection
Article Nanoscience & Nanotechnology

Engineering Exosome-Like Nanovesicles Derived from Asparagus cochinchinensis Can Inhibit the Proliferation of Hepatocellular Carcinoma Cells with Better Safety Profile

Lei Zhang et al.

Summary: This study presents a promising functional nano platform derived from edible Asparagus cochinchinensis that can be utilized in anti-tumor therapy with minimal side effects.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

Add to Collection
Article Biochemistry & Molecular Biology

Effective delivery of STING agonist using exosomes suppresses tumor growth and enhances antitumor immunity

Kathleen M. McAndrews et al.

Summary: The study demonstrates the potential for using engineered exosomes to deliver STING agonists for enhanced cancer therapy outcomes, showing superior potency and uptake into dendritic cells compared to STING agonists alone. This selective targeting of the STING pathway in antigen-presenting cells results in increased accumulation of activated CD8(+) T-cells and an antitumor immune response.

JOURNAL OF BIOLOGICAL CHEMISTRY (2021)

Add to Collection
Article Medicine, Research & Experimental

Acerola exosome-like nanovesicles to systemically deliver nucleic acid medicine via oral administration

Tomohiro Umezu et al.

Summary: Extracellular vesicles derived from mammalian cells have potential as carriers for drug delivery systems, but there are still challenges to be overcome for clinical applications. In this study, acerola exosome-like nanoparticles were explored for orally administered nucleic acid drug delivery, showing successful encapsulation of miRNA and downregulation of target genes. Oral delivery of AELNs was effective in transferring small RNA to the digestive system, with peak gene-suppressing effects observed in the small intestine and liver 1 day post-administration.

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT (2021)

Add to Collection
Article Biotechnology & Applied Microbiology

Aloe derived nanovesicle as a functional carrier for indocyanine green encapsulation and phototherapy

Lupeng Zeng et al.

Summary: This study proposed a nanocarrier made from aloe with stability and leak-proofness, showing no toxicity to melanoma cells, and demonstrating good efficacy both in vitro and in vivo. The nanocarrier showed great stability and effectiveness in delivering Indocyanine green, with potential applications in noninvasive transdermal administration.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

Add to Collection
Article Oncology

Plasmatic Exosome Number and Size Distinguish Prostate Cancer Patients From Healthy Individuals: A Prospective Clinical Study

Mariantonia Logozzi et al.

Summary: This study reveals that higher levels and smaller sizes of exosomes in plasma may serve as valuable diagnostic markers for prostate cancer, suggesting a potential non-invasive clinical approach and screening test for early diagnosis. This concept could be extended to various types of cancers based on both pre-clinical evidence and clinical data.

FRONTIERS IN ONCOLOGY (2021)

Add to Collection
Article Medicine, General & Internal

Interim findings from first-dose mass COVID-19 vaccination roll-out and COVID-19 hospital admissions in Scotland: a national prospective cohort study

Eleftheria Vasileiou et al.

Summary: The study in Scotland found that the first doses of the BNT162b2 mRNA and ChAdOx1 vaccines were associated with substantial reductions in the risk of COVID-19 hospital admission, with vaccine effectiveness ranging from 88% to 91% at 28-34 days post-vaccination.

LANCET (2021)

Add to Collection
Article Medicine, General & Internal

Impact and effectiveness of mRNA BNT162b2 vaccine against SARS-CoV-2 infections and COVID-19 cases, hospitalisations, and deaths following a nationwide vaccination campaign in Israel: an observational study using national surveillance data

Eric J. Haas et al.

Summary: This study assessed the real-world effectiveness of the Pfizer-BioNTech mRNA COVID-19 vaccine BNT162b2 in Israel, showing high efficacy in preventing SARS-CoV-2 infections, hospitalizations, severe disease, and death. As vaccine coverage increased, there were marked declines in SARS-CoV-2 outcomes, indicating that COVID-19 vaccination can help control the pandemic.

LANCET (2021)

Add to Collection
Article Engineering, Biomedical

Isolation of cabbage exosome-like nanovesicles and investigation of their biological activities in human cells

Jae Young You et al.

Summary: Studies on plant-derived exosome-like nanovesicles from cabbage and red cabbage have shown promising biological functions and potential applications, demonstrating their wide utilization as novel therapeutic biomaterials.

BIOACTIVE MATERIALS (2021)

Add to Collection
Article Medicine, General & Internal

Thrombotic Thrombocytopenia after ChAdOx1 nCov-19 Vaccination

Andreas Greinacher et al.

Summary: After vaccination with ChAdOx1 nCov-19, rare immune thrombotic thrombocytopenia can occur due to platelet-activating antibodies against PF4, resulting in various thrombotic events. Most patients in this case series were women, with fatal outcomes such as cerebral venous thrombosis and intracranial hemorrhage. Additional studies are needed to further investigate and understand this phenomenon.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Add to Collection
Article Multidisciplinary Sciences

Delivery of functional exogenous proteins by plant-derived vesicles to human cells in vitro

Luiza Garaeva et al.

Summary: Plant-derived extracellular vesicles (EVs) are gaining attention as promising carriers for delivering exogenous bioactive molecules to human cells. In this study, grapefruit EVs were isolated and characterized, showing efficient delivery of proteins to human cells and significant uptake by organs in mice. These findings suggest that native plant EVs could be safe and effective carriers for exogenous proteins.

SCIENTIFIC REPORTS (2021)

Add to Collection
Review Immunology

The Implementation of Mass-Vaccination against SARS-CoV-2: A Systematic Review of Existing Strategies and Guidelines

Tasnim Hasan et al.

Summary: This systematic review summarized the global mass-vaccination efforts for COVID-19 in the first three months, showing prioritization of frontline healthcare workers and elderly in all policies but limited information on staffing, cold chain, etc. Studies indicated that vaccination led to reduced spread of the virus and severity of cases.

VACCINES (2021)

Add to Collection
Article Medicine, Research & Experimental

A human chorionic gonadotropin (hCG) delivery platform using engineered uterine exosomes to improve endometrial receptivity

Hamed Hajipour et al.

Summary: This study demonstrated the potential of uterine fluid-derived exosomes as a carrier for delivering hCG to endometrial cells, enhancing endometrial receptivity. The effect of hCG-loaded exosomes on endometrial receptivity exceeded that of hCG or exosomes alone. Furthermore, hCG-loaded exosomes showed enhanced regulation of specific gene expression compared to hCG alone.

LIFE SCIENCES (2021)

Add to Collection
Article Chemistry, Multidisciplinary

General and mild modification of food-derived extracellular vesicles for enhanced cell targeting

Chaoxiang Chen et al.

Summary: A general and mild modification method via reduction of disulfide groups to maleimide reactive thiols was used to tether various ligands on the surface of milk-derived EVs without compromising vesicular structures. The heterogeneous nature of the functionalized samples was revealed using an ultra-sensitive nano-flow cytometer, and a magnetic separation approach was proposed to remove non-EV particles. Cellular uptake and cytotoxicity experiments demonstrated enhanced cell targeting and cargo delivery capability of the ligand conjugated EVs.

NANOSCALE (2021)

Add to Collection
Article Engineering, Biomedical

Gemcitabine loaded autologous exosomes for effective and safe chemotherapy of pancreatic cancer

Yong-Jiang Li et al.

ACTA BIOMATERIALIA (2020)

Add to Collection
Article Chemistry, Multidisciplinary

Exosome-mediated siRNA delivery to suppress postoperative breast cancer metastasis

Liuwan Zhao et al.

JOURNAL OF CONTROLLED RELEASE (2020)

Add to Collection
Article Biochemistry & Molecular Biology

Plasmatic exosomes from prostate cancer patients show increased carbonic anhydrase IX expression and activity and low pH

Mariantonia Logozzi et al.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2020)

Add to Collection
Article Biotechnology & Applied Microbiology

Engineered exosomes for targeted co-delivery of miR-21 inhibitor and chemotherapeutics to reverse drug resistance in colon cancer

Gaofeng Liang et al.

JOURNAL OF NANOBIOTECHNOLOGY (2020)

Add to Collection
Review Cell Biology

Cloaked Viruses and Viral Factors in Cutting Edge Exosome-Based Therapies

Christos Dogrammatzis et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

Add to Collection
Review Pharmacology & Pharmacy

Development of New Strategies Using Extracellular Vesicles Loaded with Exogenous Nucleic Acid

Nicola Salvatore Orefice

PHARMACEUTICS (2020)

Add to Collection
Article Chemistry, Multidisciplinary

Natural -lipid nanoparticle-based therapeutic approach to deliver 6-shogaol and its metabolites M2 and M13 to the colon to treat ulcerative colitis

Chunhua Yang et al.

JOURNAL OF CONTROLLED RELEASE (2020)

Add to Collection
Article Nanoscience & Nanotechnology

Characterization of and isolation methods for plant leaf nanovesicles and small extracellular vesicles

Yuan Liu et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2020)

Add to Collection
Article Multidisciplinary Sciences

ChAdOx1 nCoV-19 vaccine prevents SARS-CoV-2 pneumonia in rhesus macaques

Neeltje van Doremalen et al.

NATURE (2020)

Add to Collection
Article Multidisciplinary Sciences

A perspective on potential antibody-dependent enhancement of SARS-CoV-2

Ann M. Arvin et al.

NATURE (2020)

Add to Collection
Letter Medicine, General & Internal

Use of adenovirus type-5 vectored vaccines: a cautionary tale

Susan P. Buchbinder et al.

LANCET (2020)

Add to Collection
Article Materials Science, Multidisciplinary

Engineered exosome for NIR-triggered drug delivery and superior synergistic chemo-phototherapy in a glioma model

Guangmeng Li et al.

APPLIED MATERIALS TODAY (2020)

Add to Collection
Review Biotechnology & Applied Microbiology

Plant-Derived Nanovesicles: A Novel Form of Nanomedicine

Lanlan Yu et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

Add to Collection
Review Medicine, General & Internal

Biological properties and therapeutic effects of plant-derived nanovesicles

Sante Di Gioia et al.

OPEN MEDICINE (2020)

Add to Collection
Article Medicine, Research & Experimental

Enhanced exosome-mediated delivery of black bean phytochemicals (Phaseolus vulgaris L.) for cancer treatment applications

Javier Donoso-Quezada et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

Add to Collection
Review Immunology

Immunological considerations for COVID-19 vaccine strategies

Mangalakumari Jeyanathan et al.

NATURE REVIEWS IMMUNOLOGY (2020)

Add to Collection
Article Medicine, Research & Experimental

Tumor cell-derived exosomes home to their cells of origin and can be used as Trojan horses to deliver cancer drugs

Li Qiao et al.

THERANOSTICS (2020)

Add to Collection
Article Pharmacology & Pharmacy

Human primary macrophages scavenge AuNPs and eliminate it through exosomes. A natural shuttling for nanomaterials

Mariantonia Logozzi et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2019)

Add to Collection
Review Cell Biology

Exosomes: cell-created drug delivery systems

Anastasia Familtseva et al.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2019)

Add to Collection
Article Pharmacology & Pharmacy

Paclitaxel incorporated exosomes derived from glioblastoma cells: comparative study of two loading techniques

Soodeh Salarpour et al.

DARU-JOURNAL OF PHARMACEUTICAL SCIENCES (2019)

Add to Collection
Article Biotechnology & Applied Microbiology

Functional exosome-mediated co-delivery of doxorubicin and hydrophobically modified microRNA 159 for triple-negative breast cancer therapy

Chunai Gong et al.

JOURNAL OF NANOBIOTECHNOLOGY (2019)

Add to Collection
Article Medicine, Research & Experimental

Real-Time Monitoring of Exosome Enveloped-MV Spreading by Endomicroscopy Approach: A New Tool for Gene Delivery in the Brain

Nicola Salvatore Orefice et al.

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT (2019)

Add to Collection
Article Biochemistry & Molecular Biology

In Vitro Wound Healing Activity of Wheat-Derived Nanovesicles

Fikrettin Sahin et al.

APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY (2019)

Add to Collection
Review Medicine, Research & Experimental

Extracellular vesicle-based drug delivery systems for cancer treatment

Sierra Walker et al.

THERANOSTICS (2019)

Add to Collection
Article Chemistry, Multidisciplinary

Designer Exosomes for Active Targeted Chemo-Photothermal Synergistic Tumor Therapy

Jie Wang et al.

ADVANCED FUNCTIONAL MATERIALS (2018)

Add to Collection
Article Nanoscience & Nanotechnology

A33 antibody-functionalized exosomes for targeted delivery of doxorubicin against colorectal cancer

Yan Li et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2018)

Add to Collection
Article Nanoscience & Nanotechnology

Engineering macrophage-derived exosomes for targeted paclitaxel delivery to pulmonary metastases: in vitro and in vivo evaluations

Myung Soo Kim et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2018)

Add to Collection
Article Multidisciplinary Sciences

Plants send small RNAs in extracellular vesicles to fungal pathogen to silence virulence genes

Qiang Cai et al.

SCIENCE (2018)

Add to Collection
Review Materials Science, Biomaterials

Advances in plant-derived edible nanoparticle-based lipid nano-drug delivery systems as therapeutic nanomedicines

Chunhua Yang et al.

JOURNAL OF MATERIALS CHEMISTRY B (2018)

Add to Collection
Article Multidisciplinary Sciences

Arrowtail RNA for Ligand Display on Ginger Exosome-like Nanovesicles to Systemic Deliver siRNA for Cancer Suppression

Zhefeng Li et al.

SCIENTIFIC REPORTS (2018)

Add to Collection
Article Oncology

Microenvironmental pH and Exosome Levels Interplay in Human Cancer Cell Lines of Different Histotypes

Mariantonia Logozzi et al.

CANCERS (2018)

Add to Collection
Article Chemistry, Multidisciplinary

Exosome as a Vehicle for Delivery of Membrane Protein Therapeutics, PH20, for Enhanced Tumor Penetration and Antitumor Efficacy

Yeonsun Hong et al.

ADVANCED FUNCTIONAL MATERIALS (2018)

Add to Collection
Article Biochemistry & Molecular Biology

Acridine Orange/exosomes increase the delivery and the effectiveness of Acridine Orange in human melanoma cells: A new prototype for theranostics of tumors

Elisabetta Iessi et al.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2017)

Add to Collection
Article Biotechnology & Applied Microbiology

Broccoli-Derived Nanoparticle Inhibits Mouse Colitis by Activating Dendritic Cell AMP-Activated Protein Kinase

Zhongbin Deng et al.

MOLECULAR THERAPY (2017)

Add to Collection
Article Biotechnology & Applied Microbiology

Oral administration of ginger-derived nanolipids loaded with siRNA as a novel approach for efficient siRNA drug delivery to treat ulcerative colitis

Mingzhen Zhang et al.

NANOMEDICINE (2017)

Add to Collection
Article Multidisciplinary Sciences

Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer

Sushrut Kamerkar et al.

NATURE (2017)

Add to Collection
Article Biochemistry & Molecular Biology

Exosome-mediated inflammasome signaling after central nervous system injury

Juan Pablo de Rivero Vaccari et al.

JOURNAL OF NEUROCHEMISTRY (2016)

Add to Collection
Article Oncology

Dendritic cell-derived exosomes as maintenance immunotherapy after first line chemotherapy in NSCLC

Benjamin Besse et al.

ONCOIMMUNOLOGY (2016)

Add to Collection
Editorial Material Chemistry, Multidisciplinary

Evidence-Based Clinical Use of Nanoscale Extracellular Vesicles in Nanomedicine

Stefano Fais et al.

ACS NANO (2016)

Add to Collection
Review Pharmacology & Pharmacy

PEGylation as a strategy for improving nanoparticle-based drug and gene delivery

Jung Soo Suk et al.

ADVANCED DRUG DELIVERY REVIEWS (2016)

Add to Collection
Article Engineering, Biomedical

Edible ginger-derived nanoparticles: A novel therapeutic approach for the prevention and treatment of inflammatory bowel disease and colitis-associated cancer

Mingzhen Zhang et al.

BIOMATERIALS (2016)

Add to Collection
Article Biotechnology & Applied Microbiology

Grapefruit-derived Nanovectors Delivering Therapeutic miR17 Through an Intranasal Route Inhibit Brain Tumor Progression

Xiaoying Zhuang et al.

MOLECULAR THERAPY (2016)

Add to Collection
Article Oncology

Grapefruit-derived nanovectors deliver miR-18a for treatment of liver metastasis of colon cancer by induction of M1 macrophages

Yun Teng et al.

ONCOTARGET (2016)

Add to Collection
Review Medicine, Research & Experimental

Plant derived edible nanoparticles as a new therapeutic approach against diseases

Mingzhen Zhang et al.

TISSUE BARRIERS (2016)

Add to Collection
Article Oncology

Grapefruit-Derived Nanovectors Use an Activated Leukocyte Trafficking Pathway to Deliver Therapeutic Agents to Inflammatory Tumor Sites

Qilong Wang et al.

CANCER RESEARCH (2015)

Add to Collection
Article Chemistry, Multidisciplinary

Microvesicle- and exosome-mediated drug delivery enhances the cytotoxicity of Paclitaxel in autologous prostate cancer cells

Heikki Saari et al.

JOURNAL OF CONTROLLED RELEASE (2015)

Add to Collection
Article Chemistry, Multidisciplinary

Using exosomes, naturally-equipped nanocarriers, for drug delivery

Elena V. Batrakova et al.

JOURNAL OF CONTROLLED RELEASE (2015)

Add to Collection
Article Oncology

Citrus limon-derived nanovesicles inhibit cancer cell proliferation and suppress CML xenograft growth by inducing TRAIL-mediated cell death

Stefania Raimondo et al.

ONCOTARGET (2015)

Add to Collection
Review Cell Biology

Biological properties of extracellular vesicles and their physiological functions

Maria Yanez-Mo et al.

JOURNAL OF EXTRACELLULAR VESICLES (2015)

Add to Collection
Article Cell Biology

Applying extracellular vesicles based therapeutics in clinical trials - an ISEV position paper

Thomas Lener et al.

JOURNAL OF EXTRACELLULAR VESICLES (2015)

Add to Collection
Article Cell Biology

Potential functional applications of extracellular vesicles: a report by the NIH Common Fund Extracellular RNA Communication Consortium

Peter J. Quesenberry et al.

JOURNAL OF EXTRACELLULAR VESICLES (2015)

Add to Collection
Article Biotechnology & Applied Microbiology

Targeted Drug Delivery to Intestinal Macrophages by Bioactive Nanovesicles Released from Grapefruit

Baomei Wang et al.

MOLECULAR THERAPY (2014)

Add to Collection
Article Multidisciplinary Sciences

Exosome Release and Low pH Belong to a Framework of Resistance of Human Melanoma Cells to Cisplatin

Cristina Federici et al.

PLOS ONE (2014)

Add to Collection
Article Biotechnology & Applied Microbiology

Grape Exosome-like Nanoparticles Induce Intestinal Stem Cells and Protect Mice From DSS-Induced Colitis

Songwen Ju et al.

MOLECULAR THERAPY (2013)

Add to Collection
Article Multidisciplinary Sciences

Delivery of therapeutic agents by nanoparticles made of grapefruit-derived lipids

Qilong Wang et al.

NATURE COMMUNICATIONS (2013)

Add to Collection
Article Biotechnology & Applied Microbiology

A Novel Nanoparticle Drug Delivery System: The Anti-inflammatory Activity of Curcumin Is Enhanced When Encapsulated in Exosomes

Dongmei Sun et al.

MOLECULAR THERAPY (2010)

Add to Collection
Article Biotechnology & Applied Microbiology

Phase I clinical trial of autologous ascites-derived exosomes combined with GM-CSF for colorectal cancer

Shengming Dai et al.

MOLECULAR THERAPY (2008)

Add to Collection
Article Medicine, Research & Experimental

Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes:: results of thefirst phase I clinical trial

B Escudier et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2005)

Add to Collection
Article Medicine, Research & Experimental

A phase I study of dexosome immunotherapy in patients with advanced non-small cell lung cancer

MA Morse et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2005)

Add to Collection
Webinars Posters Questions Hubs Funding Journals Papers Connect Collections Reviewers About Us FAQs Mobile App Privacy Policy Terms of Use
© Peeref 2019-2024. All rights reserved.