4.2 Review

Advances in pharmacotherapy for ulcerative colitis: a focus on JAK1 inhibitors

Related references

Note: Only part of the references are listed.
Article Rheumatology

Identification of two tofacitinib subpopulations with different relative risk versus TNF inhibitors: an analysis of the open label, randomised controlled study ORAL Surveillance

Lars Erik Kristensen et al.

Summary: Based on primary results from ORAL Surveillance, this study identified two subpopulations of patients treated with tofacitinib who had different relative risks compared to TNFi. Older age and smoking were identified as risk factors associated with increased risk, while younger age and non-smoking were associated with no detectable risk increase. These findings have important implications for individualized treatment decisions with tofacitinib.

ANNALS OF THE RHEUMATIC DISEASES (2023)

Article Gastroenterology & Hepatology

Oral Ritlecitinib and Brepocitinib for Moderate-to-Severe Ulcerative Colitis: Results From a Randomized, Phase 2b Study

William J. Sandborn et al.

Summary: The efficacy and safety of ritlecitinib and brepocitinib as induction therapy were evaluated in patients with active, moderate-to-severe ulcerative colitis.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2023)

Review Gastroenterology & Hepatology

Positioning Filgotinib in the Treatment Algorithm of Moderate to Severe Ulcerative Colitis

Ferdinando D'Amico et al.

Summary: Filgotinib is an effective and safe drug for the treatment of moderate to severe UC, showing similar efficacy but lower risks of thrombosis and herpes zoster infections compared to other JAK inhibitors. However, there may be potential effects on male reproductive organs that require further investigation in human studies.

JOURNAL OF CROHNS & COLITIS (2022)

Article Gastroenterology & Hepatology

DOP38 Upadacitinib Therapy Reduces Ulcerative Colitis Symptoms as Early as Day 1

S Vermeire et al.

Journal of Crohns & Colitis (2022)

Article Medicine, General & Internal

Cardiovascular and Cancer Risk with Tofacitinib in Rheumatoid Arthritis

Steven R. Ytterberg et al.

Summary: In this trial comparing the use of tofacitinib with a TNF inhibitor in a cardiovascular risk-enriched population, the risks of major adverse cardiovascular events (MACE) and cancers were found to be higher with tofacitinib, and it did not meet noninferiority criteria. Several adverse events were more common with tofacitinib.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

Review Gastroenterology & Hepatology

Efficacy and safety of biologics and small molecule drugs for patients with moderate-to-severe ulcerative colitis: a systematic review and network meta-analysis

Juan S. Lasa et al.

Summary: This study compares the efficacy and safety of biologics and small molecule drugs for the treatment of moderate-to-severe ulcerative colitis. The findings show that Upadacitinib performs well in inducing clinical remission, while Vedolizumab performs best in terms of safety.

LANCET GASTROENTEROLOGY & HEPATOLOGY (2022)

Review Pharmacology & Pharmacy

Filgotinib: A Clinical Pharmacology Review

Florence Namour et al.

Summary: Filgotinib is an oral medication used for the treatment of rheumatoid arthritis and ulcerative colitis. It modulates inflammatory responses by selectively inhibiting JAK1 and is rapidly absorbed and metabolized in the body.

CLINICAL PHARMACOKINETICS (2022)

Review Immunology

Emerging therapies for ulcerative colitis

Jurij Hanzel et al.

Summary: This article introduces three categories of drugs recently approved or awaiting approval for the treatment of ulcerative colitis (UC), including antibodies against interleukin-23 (IL-23), sphingosine-1-phosphate receptor (S1PR) modulators, and selective inhibitors of Janus kinases (JAK). These drugs have demonstrated good efficacy and safety, but further research and development are needed.

EXPERT REVIEW OF CLINICAL IMMUNOLOGY (2022)

Article Gastroenterology & Hepatology

Efficacy and safety of filgotinib as induction and maintenance therapy for Japanese patients with moderately to severely active ulcerative colitis: a post-hoc analysis of the phase 2b/3 SELECTION trial

Toshifumi Hibi et al.

Summary: This study evaluated the safety and efficacy of filgotinib in Japanese patients with UC. The results suggest that filgotinib 200 mg may be a viable treatment option for Japanese patients with UC, but caution should be exercised due to the small patient numbers.

INTESTINAL RESEARCH (2022)

Article Gastroenterology & Hepatology

Efficacy and Safety of Ivarmacitinib in Patients With Moderate-to-Severe, Active, Ulcerative Colitis: A Phase II Study

Baili Chen et al.

Summary: This study evaluated the efficacy and safety of the selective JAK1 inhibitor ivarmacitinib in patients with moderate-to-severe active UC. The results showed that ivarmacitinib demonstrated clinical efficacy and was well tolerated in treating UC. This provides a promising new treatment option for moderate-to-severe UC.

GASTROENTEROLOGY (2022)

Editorial Material Gastroenterology & Hepatology

Is Selectivity the JAKpot Winner for Inflammatory Bowel Disease Treatment?

Ferdinando D'Amico et al.

GASTROENTEROLOGY (2022)

Article Rheumatology

Safety and Efficacy of Filgotinib: Up to 4-year Results From an Open-label Extension Study of Phase II Rheumatoid Arthritis Programs

Arthur Kavanaugh et al.

Summary: The long-term use of filgotinib for the treatment of rheumatoid arthritis, either with or without methotrexate, showed good safety and efficacy with ACR20/50/70 responses maintained over 4 years, comparable to the parent trials.

JOURNAL OF RHEUMATOLOGY (2021)

Article Rheumatology

JAK1 inhibition and inflammatory bowel disease

Clare Harris et al.

Summary: Primary non-response and secondary loss of response are still significant issues with current treatment options for inflammatory bowel disease, highlighting the need for new therapeutic choices. As our understanding of IBD pathogenesis advances, new therapeutic targets are being identified.

RHEUMATOLOGY (2021)

Article Dermatology

Efficacy and Safety of SHR0302, a Highly Selective Janus Kinase 1 Inhibitor, in Patients with Moderate to Severe Atopic Dermatitis: A Phase II Randomized Clinical Trial

Yan Zhao et al.

Summary: Oral SHR0302 demonstrated effectiveness and good tolerance in Chinese adult patients with moderate to severe atopic dermatitis, leading to improved disease assessment response rate and Eczema Area and Severity Index. However, mild treatment-emergent adverse events were reported in some patients.

AMERICAN JOURNAL OF CLINICAL DERMATOLOGY (2021)

Article Medicine, General & Internal

Current and future status of JAK inhibitors

Donal P McLornan et al.

LANCET (2021)

Article Medicine, General & Internal

Filgotinib as induction and maintenance therapy for ulcerative colitis (SELECTION): a phase 2b/3 double-blind, randomised, placebo-controlled trial

Brian G. Feagan et al.

Summary: The study assessed the efficacy and safety of filgotinib in treating ulcerative colitis, with the results showing that 200 mg of filgotinib was more effective than placebo in inducing and maintaining clinical remission.

LANCET (2021)

Review Biochemistry & Molecular Biology

The JAK/STAT signaling pathway: from bench to clinic

Xiaoyi Hu et al.

Summary: The JAK/STAT signaling pathway is a crucial cellular signal transduction pathway, associated with various cancers and autoimmune diseases. Researchers discussed the composition, activation, and regulation of this pathway, as well as its role in diseases.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

Article Rheumatology

Postapproval Comparative Safety Study of Tofacitinib and Biological Disease-Modifying Antirheumatic Drugs: 5-Year Results from a United States-Based Rheumatoid Arthritis Registry

Joel M. Kremer et al.

Summary: This study compared 5-year adverse event incidence rates between tofacitinib and bDMARD initiators in a US registry, finding similar rates for major adverse cardiovascular events, serious infection events, malignancies, death, and venous thromboembolic events, but significantly higher rates of herpes zoster in the tofacitinib group.

ACR OPEN RHEUMATOLOGY (2021)

Article Rheumatology

Adverse events of special interest in clinical trials of rheumatoid arthritis, psoriatic arthritis, ulcerative colitis and psoriasis with 37 066 patient-years of tofacitinib exposure

Gerd R. Burmester et al.

Summary: This study analyzed adverse events of special interest in tofacitinib clinical programs across four diseases, finding that infections were the most common adverse events in all diseases. The incidence rates for herpes zoster and serious infections were highest, and the adjusted mortality ratios weighted for country were relatively low across cohorts. The safety profile of tofacitinib was generally consistent across diseases and with longer term follow-up compared to previous analyses.

RMD OPEN (2021)

Review Pharmacology & Pharmacy

Clinical Pharmacokinetics of Upadacitinib: Review of Data Relevant to the Rheumatoid Arthritis Indication

Mohamed-Eslam F. Mohamed et al.

CLINICAL PHARMACOKINETICS (2020)

Article Gastroenterology & Hepatology

Efficacy and Safety of Upadacitinib in a Randomized Trial of Patients With Crohn's Disease

William J. Sandborn et al.

GASTROENTEROLOGY (2020)

Editorial Material Gastroenterology & Hepatology

Global burden of inflammatory bowel disease

Vipul Jairath et al.

LANCET GASTROENTEROLOGY & HEPATOLOGY (2020)

Article Gastroenterology & Hepatology

Clinical Pharmacology of Janus Kinase Inhibitors in Inflammatory Bowel Disease

Pavine L. C. Lefevre et al.

JOURNAL OF CROHNS & COLITIS (2020)

Review Gastroenterology & Hepatology

JAK-STAT pathway targeting for the treatment of inflammatory bowel disease

Azucena Salas et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2020)

Editorial Material Gastroenterology & Hepatology

Tofacitinib for Acute Severe Colitis: When the going Gets Tough, the Tough Get Going

Ferdinando D'Amico et al.

JOURNAL OF CROHNS & COLITIS (2020)

Article Gastroenterology & Hepatology

JAK selectivity for inflammatory bowel disease treatment: does it clinically matter?

Silvio Danese et al.

Article Gastroenterology & Hepatology

Next generation of small molecules in inflammatory bowel disease

Pablo Olivera et al.

Review Medicine, General & Internal

Ulcerative colitis

Ryan Ungaro et al.

LANCET (2017)

Article Medicine, General & Internal

Tofacitinib as Induction and Maintenance Therapy for Ulcerative Colitis

William J. Sandborn et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Review Gastroenterology & Hepatology

JAK inhibition using tofacitinib for inflammatory bowel disease treatment: a hub for multiple inflammatory cytokines

Silvio Danese et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2016)

Review Biochemistry & Molecular Biology

The molecular regulation of Janus kinase (JAK) activation

Jeffrey J. Babon et al.

BIOCHEMICAL JOURNAL (2014)

Review Immunology

Cytokines in inflammatory bowel disease

Markus F. Neurath

NATURE REVIEWS IMMUNOLOGY (2014)

Article Medicine, General & Internal

Ulcerative colitis

Ingrid Ordas et al.

LANCET (2012)