Journal
EXPERT OPINION ON BIOLOGICAL THERAPY
Volume 23, Issue 3, Pages 269-282Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14712598.2023.2184256
Keywords
Brain tumor; clinical trial; glioma; immunotherapy; oncolytic virus therapy; preclinical study; tumor microenvironment
Ask authors/readers for more resources
Oncolytic viruses (OVs) are innovative therapeutic approach for treating malignant brain tumors, featuring unique mechanisms of action. The recent conditional approval of oncolytic herpes simplex virus G47 Delta as a therapeutic for malignant brain tumors is a significant milestone in the field of neuro-oncology.
IntroductionTo overcome the challenge of treating malignant brain tumors, oncolytic viruses (OVs) represent an innovative therapeutic approach, featuring unique mechanisms of action. The recent conditional approval of the oncolytic herpes simplex virus G47 Delta as a therapeutic for malignant brain tumors marked a significant milestone in the long history of OV development in neuro-oncology.Areas coveredThis review summarizes the results of recently completed and active clinical studies that investigate the safety and efficacy of different OV types in patients with malignant gliomas. The changing landscape of the OV trial design includes expansion of subjects to newly diagnosed tumors and pediatric populations. A variety of delivery methods and new routes of administration are vigorously tested to optimize tumor infection and overall efficacy. New therapeutic strategies such as combination with immunotherapies are proposed that take advantage of the characteristics of OV therapy as an immunotherapy. Preclinical studies of OV have been active and aim to translate new OV strategies to the clinic.Expert opinionFor the next decade, clinical trials and preclinical and translational research will continue to drive the development of innovative OV treatments for malignant gliomas and benefit patients and define new OV biomarkers.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available