Sensory and motor fibroblasts have different protein expression patterns and exert different growth promoting effects on sensory and motor neurons

Article Cell Biology

Peripheral nerve fibroblasts secrete neurotrophic factors to promote axon growth of motoneurons

Qian-Ru He et al.

Summary: Peripheral nerve fibroblasts play a critical role in nerve development and regeneration by promoting motoneuron neurite outgrowth. These fibroblasts exhibit different patterns of gene expression compared to cardiac fibroblasts.

NEURAL REGENERATION RESEARCH (2022)

Add to Collection

Article Neurosciences

Preferential regeneration and collateral dynamics of motor and sensory neurons after nerve injury in mice

Sara Bolivar et al.

Summary: Specificity in regeneration after peripheral nerve injuries is crucial for functional recovery. This study found that cutaneous mechanoreceptors regenerated faster than other neuron populations, followed by motoneurons and then proprioceptors. Additionally, all neuron types initially preferred to regenerate into the cutaneous branch, but in the long term, they mainly regenerated through their original branch. Furthermore, motoneurons had more collateral branches than proprioceptors, and myelinated neurons extended more regenerative sprouts in the cutaneous branch.

EXPERIMENTAL NEUROLOGY (2022)

Add to Collection

Article Neurosciences

Activin A Secreted From Peripheral Nerve Fibroblasts Promotes Proliferation and Migration of Schwann Cells

Yan Li et al.

Summary: The study demonstrates the differential effects of peripheral nerve fibroblasts and cardiac fibroblasts on Schwann cells, with peripheral nerve fibroblasts significantly promoting Schwann cell proliferation and migration. Cytokine array analysis identified differentially expressed proteins between peripheral nerve fibroblasts and cardiac fibroblasts, with activin A being the protein with the greatest differential expression. In vitro experiments confirmed that activin A secreted from nerve fibroblasts is responsible for boosting proliferation and migration of Schwann cells through specific signaling pathways.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2022)

Add to Collection

Article Neurosciences

Cell populations in neonatal rat peripheral nerves identified by single-cell transcriptomics

Ruirui Zhang et al.

Summary: The study used high-coverage single-cell sequencing to reveal the cell diversity and heterogeneity of Schwann cells in the peripheral nerves of neonatal rats. A total of 10 cell types were identified in SN and DRG with distinct cell-cell communication patterns.

GLIA (2021)

Add to Collection

Article Neurosciences

A proteomic view on the differential phenotype of Schwann cells derived from mouse sensory and motor nerves

Mi Shen et al.

Summary: This study provides a proteomic view of the differential phenotype of mouse SNdSCs and MNdSCs. The data may serve as a valuable source for studying the biological characteristics and roles of these two SC phenotypes in nerve-specific regeneration.

JOURNAL OF COMPARATIVE NEUROLOGY (2021)

Add to Collection

Article Biochemical Research Methods

Comparative Proteomic Analysis of Differentially Expressed Proteins between Injured Sensory and Motor Nerves after Peripheral Nerve Transection

Qianru He et al.

Summary: Peripheral nerve repair and functional recovery depend on the rate of nerve regeneration and the quality of target reinnervation. A quantitative proteomic technique was used to analyze the protein expression pattern between injured motor and sensory nerves, revealing 176 proteins with differential expressions. Functional categorization indicated that these differentially expressed proteins are linked to various molecular functions, which might play a crucial role in peripheral nerve regeneration.

JOURNAL OF PROTEOME RESEARCH (2021)

Add to Collection

Review Cell Biology