4.6 Article

PHLDA3 activated by BARX2 transcription, suppresses the malignant development of esophageal squamous cell carcinoma by downregulating PI3K/AKT levels

Related references

Note: Only part of the references are listed.
Article Biotechnology & Applied Microbiology

Pleckstrin homology-like domain family A, member 3, a miR-19a-3p-regulated gene, suppresses tumor growth in osteosarcoma by downregulating the Akt pathway

Peng Wang et al.

Summary: The low expression of PHLDA3 is associated with poor prognosis in osteosarcoma patients. Activating PHLDA3 can suppress osteosarcoma cell proliferation, migration, and chemoresistance, while inhibiting PHLDA3 has the opposite effects. Furthermore, miR-19a-3p may exert its oncogenic function in osteosarcoma by inhibiting PHLDA3 expression.

BIOENGINEERED (2022)

Article Surgery

Morbidity and Mortality of Patients Who Underwent Minimally Invasive Esophagectomy After Neoadjuvant Chemoradiotherapy vs Neoadjuvant Chemotherapy for Locally Advanced Esophageal Squamous Cell Carcinoma A Randomized Clinical Trial

Hao Wang et al.

Summary: The study compared the safety and long-term survival outcomes of neoadjuvant chemoradiotherapy (nCRT) followed by minimally invasive esophagectomy (MIE) with neoadjuvant chemotherapy (nCT) followed by MIE for locally advanced esophageal squamous cell carcinoma (ESCC) patients. The initial results showed that nCRT followed by MIE had similar safety and better pathologic outcomes compared to nCT followed by MIE for treating locally advanced ESCC.

JAMA SURGERY (2021)

Article Biochemistry & Molecular Biology

PHLDA3 exerts an antitumor function in prostate cancer by down-regulating Wnt/β-catenin pathway via inhibition of Akt

Shuaijun Ma et al.

Summary: PHLDA3 is a novel tumor-related protein that shows lower abundance in prostate cancer, and its low levels are associated with reduced survival in prostate cancer patients. Demethylation treatment can up-regulate PHLDA3 expression and suppress proliferation and metastasis of prostate cancer cells. Overexpression of PHLDA3 inhibits Wnt/beta-catenin pathway via the inhibition of Akt, highlighting its potential as a novel anticancer target for prostate cancer.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

Article Oncology

Regulation of angiogenesis by microRNAs in cancer

Qi Zheng et al.

Summary: MicroRNAs (miRs) are small non-coding RNA molecules that play key roles in regulating gene expression and cellular functions, particularly in angiogenesis related to tumor development and progression. Investigating the roles of miRs in angiogenesis may lead to novel strategies for treating tumors, and their potential as biomarkers for diagnosing and monitoring therapy response is also being explored.

MOLECULAR MEDICINE REPORTS (2021)

Letter Oncology

PAK5-stabilized Smuc confers renal cell carcinoma metastasis

Fu-Chun Huo et al.

CLINICAL AND TRANSLATIONAL MEDICINE (2021)

Article Multidisciplinary Sciences

TRIM21 and PHLDA3 negatively regulate the crosstalk between the PI3K/AKT pathway and PPP metabolism

Jie Cheng et al.

NATURE COMMUNICATIONS (2020)

Article Medicine, Research & Experimental

Regulation of Hippo/YAP signaling and Esophageal Squamous Carcinoma progression by an E3 ubiquitin PARK2

Xiaofeng Zhou et al.

THERANOSTICS (2020)

Review Cell Biology

Regulation of tumor angiogenesis by microRNAs: State of the art

Nasser H. Goradel et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

Article Gastroenterology & Hepatology

Epidemiology of Esophageal Squamous Cell Carcinoma

Christian C. Abnet et al.

GASTROENTEROLOGY (2018)

Review Gastroenterology & Hepatology

Screening for esophageal squamous cell carcinoma: recent advances

Don C. Codipilly et al.

GASTROINTESTINAL ENDOSCOPY (2018)

Article Biochemistry & Molecular Biology

phlda3 overexpression impairs specification of hemangioblasts and vascular development

Xiaojing Wang et al.

FEBS JOURNAL (2018)

Review Cell Biology

Tumor xenograft animal models for esophageal squamous cell carcinoma

Nikki P. Lee et al.

JOURNAL OF BIOMEDICAL SCIENCE (2018)

Article Biochemistry & Molecular Biology

Down-regulation of Barx2 predicts poor survival in colorectal cancer

Yushuai Mi et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)

Article Cardiac & Cardiovascular Systems

Bach1 Represses Wnt/β-Catenin Signaling and Angiogenesis

Li Jiang et al.

CIRCULATION RESEARCH (2015)

Article Multidisciplinary Sciences

PHLDA3 is a novel tumor suppressor of pancreatic neuroendocrine tumors

Rieko Ohki et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Multidisciplinary Sciences

Highly enantioselective synthesis of γ-, δ-, and ε-chiral 1-alkanols via Zr-catalyzed asymmetric carboalumination of alkenes (ZACA)-Cu- or Pd-catalyzed cross-coupling

Shiqing Xu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Medicine, General & Internal

Preoperative Chemoradiotherapy for Esophageal or Junctional Cancer

P. van Hagen et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

Review Neurosciences

PI3K/AKT/mTOR pathway in angiogenesis

Jayashree Karar et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2011)

Article Biochemistry & Molecular Biology

PH Domain-Only Protein PHLDA3 Is a p53-Regulated Repressor of Akt

Tatsuya Kawase et al.

Article Multidisciplinary Sciences

Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic

SY Kang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Biochemistry & Molecular Biology

Identification of novel binding elements and gene targets for the homeodomain protein BARX2

TA Stevens et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)