☆ 4.6 Editorial Material

If your patient with asthma wheezes when sitting or lying quietly, lung function testing may reveal small airway disease

EUROPEAN RESPIRATORY JOURNAL (2023)

Related references

Note: Only part of the references are listed.

Article Respiratory System

Development of a tool to detect small airways dysfunction in asthma clinical practice

Janwillem Kocks et al.

Summary: This study aimed to develop a simple tool to predict small airways dysfunction (SAD) in asthma, using items from the Small Airways Dysfunction Tool (SADT) questionnaire, basic patient characteristics, and available respiratory tests. Logistic regression models were built using key SADT items and clinical information to predict the likelihood of SAD. Adding spirometry and oscillometry to the models increased the diagnostic ability.

EUROPEAN RESPIRATORY JOURNAL (2023)

Add to Collection

Article Critical Care Medicine

Heterogeneity of Airway Smooth Muscle Remodeling in Asthma

Alan L. James et al.

Summary: The distribution of airway smooth muscle (ASM) remodeling in asthma varies widely within and between individuals, and is related to asthma severity. Despite the heterogeneous distribution, ASM remodeling is present in the majority of asthma cases, both in large and small airways. These findings emphasize the importance of patient-specific targeting of ASM remodeling in asthma treatment.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2023)

Add to Collection

Article Physiology

Small airways dysfunction is associated with increased exacerbations in patients with asthma

Claire F. O'Sullivan et al.

Summary: This study found that asthmatic patients with a history of exacerbations in the last year had worse peripheral airway function, while those recently treated for an asthma exacerbation had comparable peripheral airway function to the stable group. These findings suggest that active peripheral airway dysfunction may play a role in the pathophysiology of asthma exacerbations.

JOURNAL OF APPLIED PHYSIOLOGY (2022)

Add to Collection

Review Respiratory System

Structure and function of small airways in asthma patients revisited

Wytse B. van den Bosch et al.

Summary: Small airways are likely to play a role in asthma across various severities, with increasing abnormalities in both structure and function as the severity of asthma worsens. Studies using in vitro research, animal models, and imaging techniques have described the alterations in epithelium, extracellular matrix, and airway smooth muscle in the small airways of individuals with asthma over many years.

EUROPEAN RESPIRATORY REVIEW (2021)

Add to Collection

Editorial Material Physiology

Small airways vs large airways in asthma: time for a new perspective

Graham M. Donovan et al.

JOURNAL OF APPLIED PHYSIOLOGY (2021)

Add to Collection

Article Respiratory System

Detection of Small Airway Dysfunction in Asymptomatic Smokers with Preserved Spirometry: The Value of the Impulse Oscillometry System

Roberta Pisi et al.

Summary: This study investigated the detection of small airway dysfunction (SAD) using impulse oscillometry system (IOS) in asymptomatic smokers with preserved spirometry. Results showed that heavy smokers had significantly higher values of IOS index of SAD compared to mild smokers and never-smokers, indicating the potential of IOS in detecting SAD in this population.

INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (2021)

Add to Collection

Letter Physiology

Commentaries on Viewpoint: Small airways vs. large airways in asthma: time for a new perspective

Sylvia Verbanck

JOURNAL OF APPLIED PHYSIOLOGY (2021)

Add to Collection

Article Critical Care Medicine

Single-Session Bronchial Thermoplasty Guided by 129Xe Magnetic Resonance Imaging A Pilot Randomized Controlled Clinical Trial

Chase S. Hall et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2020)

Add to Collection

Article Biology

Phenotype- and patient-specific modelling in asthma: Bronchial thermoplasty and uncertainty quantification

Graham M. Donovan et al.

JOURNAL OF THEORETICAL BIOLOGY (2020)

Add to Collection

Article Physiology

Patient-specific targeted bronchial thermoplasty: predictions of improved outcomes with structure-guided treatment

Graham M. Donovan et al.

JOURNAL OF APPLIED PHYSIOLOGY (2019)

Add to Collection

Article Critical Care Medicine

Exploring the relevance and extent of small airways dysfunction in asthma (ATLANTIS): baseline data from a prospective cohort study

Dirkje S. Postma et al.

LANCET RESPIRATORY MEDICINE (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Unraveling a Clinical Paradox: Why Does Bronchial Thermoplasty Work in Asthma?

Graham M. Donovan et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2018)

Add to Collection

Article Respiratory System

Distribution of airway smooth muscle remodelling in asthma: Relation to airway inflammation

John G. Elliot et al.

RESPIROLOGY (2015)

Add to Collection

Article Health Care Sciences & Services

Development of a tool to recognize small airways dysfunction in asthma (SADT)

Lieke Schiphof-Godart et al.

HEALTH AND QUALITY OF LIFE OUTCOMES (2014)

Add to Collection

Article Respiratory System

Lung Deposition of BDP/Formoterol HFA pMDI in Healthy Volunteers, Asthmatic, and COPD Patients

Wilfried De Backer et al.

JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY (2010)

Add to Collection

Article Oncology

Receiver Operating Characteristic Curve in Diagnostic Test Assessment

Jayawant N. Mandrekar

JOURNAL OF THORACIC ONCOLOGY (2010)

Add to Collection

Article Physiology

The prone position results in smaller ventilation defects during bronchoconstriction in asthma

R. Scott Harris et al.

JOURNAL OF APPLIED PHYSIOLOGY (2009)

Add to Collection

Article Respiratory System

Aerosol deposition in the human lung periphery is increased by reduced-density gas breathing

Jonathan B. Peterson et al.

JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY (2008)

Add to Collection

Article Physiology

Effects of body posture and tidal volume on inter- and intraregional ventilation distribution in healthy men

M Grönkvist et al.

JOURNAL OF APPLIED PHYSIOLOGY (2002)

Add to Collection

© Peeref 2019-2024. All rights reserved.